Abstract: Disclosed herein are compounds and compositions useful in the treatment of GLS1 mediated diseases, such as cancer, having the structure of Formula I: Methods of inhibition GLS1 activity in a human or animal subject are also provided.

Abstract: Genetically engineered bacteria, pharmaceutical compositions thereof, and methods of modulating and treating diseases associated with hyperphenylalaninemia are disclosed.

Abstract: Embodiments of the present invention disclose packaging receptacles, modular apparatuses for manufacturing such packaging receptacles, and a method thereof. A modular apparatus for manufacturing packaging receptacles includes a paper feeder module, an embossing module, and an adhesive coating module. The paper feeder module includes a plurality of paper feeder rollers configured to feed one or more first layers of paper to the embossing module, and a second layer of paper to the adhesive coating module. The embossing module includes a first embossing roller and a second embossing roller configured to emboss a plurality of impressions onto the one or more first layers, and feed the embossed one or more first layers to the adhesive coating module. Also, the adhesive coating module is configured to apply an adhesive to an outermost surface of the embossed one or more first layers and an inner surface of the second layer.

Abstract: A method includes obtaining video data for a first set of video files, generating processing job data for a first video processing job based on the video data, identifying a first processing server having a capacity for handling the first video processing job, sending, to the first processing server, the processing job data for the first video processing job and a first request to validate the video data, receiving, from the first processing server, validation testing results in connection with the first set of video files, determining first transcoding parameters for the first set of video files based on the validation testing results and output requirements data for the first video processing job, and sending, to the first processing server, a second request to generate an output video based on the first set of video files, the second request including an indication of the first transcoding parameters.

Abstract: A method includes obtaining video data for a first set of video files, generating processing job data for a first video processing job based on the video data, identifying a first processing server having a capacity for handling the first video processing job, sending, to the first processing server, the processing job data for the first video processing job and a first request to validate the video data, receiving, from the first processing server, validation testing results in connection with the first set of video files, determining first transcoding parameters for the first set of video files based on the validation testing results and output requirements data for the first video processing job, and sending, to the first processing server, a second request to generate an output video based on the first set of video files, the second request including an indication of the first transcoding parameters.

Abstract: The present invention generally relates to the treatment of psoriasis with an antibody that binds to the p19 subunit of human IL-23, in particular dosage regimens for the treatment of the disease.

Abstract: The present invention generally relates to the treatment of Crohn's Disease with an anti-IL-23p19 antibody, particularly dosage regimens for the treatment of the disease.

Abstract: The present invention is an ultrasonic sealing method for sealing together multiple layers, of materials of different composite and may be dissimilar in nature the method comprising the steps of, a) feeding at least two work-pieces between an ultrasonic horn and an anvil, wherein said at least two work-pieces comprise a shipping envelope mailer with or without a cushion layer as a variable layered material b) sealing said two work-pieces, wherein said sealing comprises, (i) the outer layers may or may not be pre coated with a polymer and (ii) generating vibratory energy by a transducer and applying it to the horn which causes the horn to vibrate, wherein the frictional forces caused between the vibrating horn, and the anvil produces heat which is used to seal the two work-pieces together.

Abstract: The present invention generally relates to the treatment of ulcerative colitis with an anti-IL-23p19 antibody, in particular dosage regimens for the treatment of the disease.

Abstract: A processor-implemented method for authenticating a login without a password. The method includes: receiving a request to authenticate a login, the request including a user identifier and excluding a password; based on the user identifier, identifying a device to be used to authenticate the login; and in response to determining that a login confirmation message has been received from the identified device, authenticating the login.

Abstract: A processor-implemented method for authenticating a login without a password. The method includes: receiving a request to authenticate a login, the request including a user identifier and excluding a password; based on the user identifier, identifying a device to be used to authenticate the login; and in response to determining that a login confirmation message has been received from the identified device, authenticating the login.

Abstract: A processor-implemented method for authenticating a login without a password. The method includes: receiving a request to authenticate a login, the request including a user identifier and excluding a password; based on the user identifier, identifying a device to be used to authenticate the login; and in response to determining that a login confirmation message has been received from the identified device, authenticating the login.

Abstract: A processor-implemented method for authenticating a login without a password. The method includes: receiving a request to authenticate a login, the request including a user identifier and excluding a password; based on the user identifier, identifying a device to be used to authenticate the login; and in response to determining that a login confirmation message has been received from the identified device, authenticating the login.

Abstract: A tensioning device uses two perpendicular gears so that common hand tool such as wrenches or socket wrenches can be used to drive the gears to rotate a barrel having two oppositely threaded apertures. Shafts having complementary threads inserted into the threaded apertures and means for connecting chain, wire rope, cable, or straps will be extended or retracted when tools rotate the driving gear. End effectors on the shafts include hooks or clevises for securing cargo, pads for use as a jack, and ball ends for use as an adjustable mechanical linkage such as the top link of a three-point agricultural hitch. Load locks can secure the threaded shafts from unwanted rotation while in transit or in other service.

Abstract: A tensioning device uses two perpendicular gears so that common hand tool such as wrenches or socket wrenches can be used to drive the gears to rotate a barrel having two oppositely threaded apertures. Shafts having complementary threads inserted into the threaded apertures and means for connecting chain, wire rope, cable, or straps will be extended or retracted when tools rotate the driving gear. End effectors on the shafts include hooks or clevises for securing cargo, pads for use as a jack, and ball ends for use as an adjustable mechanical linkage such as the top link of a three-point agricultural hitch. Load locks can secure the threaded shafts from unwanted rotation while in transit or in other service.

Abstract: A tensioning device comprised of; a gear box containing a bevel gear assembly inside the gear box with one gear attached directly to a barrel which passes through the gear box and threaded shafts at either end of the barrel. Inside the gear box is a guide which is placed such that a drive gear and the barrel gear are engaged when assembled and a socket wrench receptacle is part of the drive gear. The threaded shafts move in and out of the barrel based on the rotation of the gear. The tensioning device uses direct gearing of the rotational motion of the drive gear to rotate the barrel causing the shafts to be linearly displaced tightening or loosening a chain, cable or strap.

Abstract: A processor-implemented method for authenticating a login without a password. The method includes: receiving a request to authenticate a login, the request including a user identifier and excluding a password; based on the user identifier, identifying a device to be used to authenticate the login; and in response to determining that a login confirmation message has been received from the identified device, authenticating the login.

Abstract: In one aspect, the present disclosure describes a server-implemented method for authenticating a login without a password. The method includes: a) receiving, from a request initiator, a request to authenticate a login, the request including a user identifier; b) providing, to a device pre-registered for use in association with the user identifier, an acknowledgement request, the device being configured to generate a prompt in response to receiving the acknowledgment request, the prompt requesting input to authenticate the login; c) initiating a timer; d) determining that a login confirmation message has been received from the pre-registered device before expiration of the timer; and e) in response to determining that the login confirmation message has been received from the pre-registered device before expiration of the timer, providing an authentication acknowledgment message to the request initiator.

Abstract: In one aspect, the present disclosure describes a server-implemented method for authenticating a login without a password. The method includes: a) receiving, from a request initiator, a request to authenticate a login, the request including a user identifier; b) providing, to a device pre-registered for use in association with the user identifier, an acknowledgement request, the device being configured to generate a prompt in response to receiving the acknowledgment request, the prompt requesting input to authenticate the login; c) initiating a timer; d) determining that a login confirmation message has been received from the pre-registered device before expiration of the timer; and e) in response to determining that the login confirmation message has been received from the pre-registered device before expiration of the timer, providing an authentication acknowledgment message to the request initiator.

Abstract: A method for predicting a need for Renal Replacement Therapy (RRT) in a patient comprises: determining a concentration of pi glutathione S transferase-(?GST) in a first urine sample from the patient; and wherein a need for RRT is predicted when the ?GST concentration is determined to be elevated in comparison to a patient without kidney injury. The method according to the invention can further comprise detecting for the presence of risk factors for RRT in a patient, the risk factors including elevated serum creatinine concentration, type I diabetes, type II diabetes, hypertension, dyslipidemia, hyperglycaemia, proteinuria and hypoalbuminemia.