Abstract: A method of treating psoriasis in a patient previously treated with and determined to be an inadequate responder to an IL-12/23p40 antibody by administering an IL-23 specific antibody, e.g., guselkumab, in a safe and effective amount and the patient achieves PASI75, PASI90, PASI100 or IGA 0 or 1 score as measured 16, 24, 32, 40 and 48 weeks after initial treatment.

Abstract: A method of treating psoriasis in a patient previously treated with and determined to be an inadequate responder to an IL-12/23p40 antibody by administering an IL-23 specific antibody, e.g., guselkumab, in a safe and effective amount and the patient achieves PASI75, PASI90, PASI100 or IGA 0 or 1 score as measured 16, 24, 32, 40 and 48 weeks after initial treatment.

Abstract: A method of treating psoriasis in a patient previously treated with and determined to be an inadequate responder to an IL-12/23p40 antibody by administering an IL-23 specific antibody, e.g., guselkumab, in a safe and effective amount and the patient achieves PASI75, PASI90, PASI100 or IGA 0 or 1 score as measured 16, 24, 32, 40 and 48 weeks after initial treatment.

Abstract: Methods, systems, and apparatus for improved dispatching of sheetsides in a high-speed (e.g., continuous form) printing environment using multiple, clustered processors in a print controller. Features and aspects hereof utilize a stochastic mathematical model of multiple processors (compute nodes) each adapted to RIP (rasterize) raw sheetside data provided to it. The model utilizes stochastic estimates of the probability of RIP execution time to select a preferred processor of the controller and dispatches the sheetside to the preferred compute node identified as providing best probability of meeting required deadlines for RIP completion time of a raw sheetside.

Abstract: Methods, systems, and apparatus for improved dispatching of sheetsides in a high-speed (e.g., continuous form) printing environment using multiple, clustered processors in a print controller. Features and aspects hereof utilize a stochastic mathematical model of multiple processors (compute nodes) each adapted to RIP (rasterize) raw sheetside data provided to it. The model utilizes stochastic estimates of the probability of RIP execution time to select a preferred processor of the controller and dispatches the sheetside to the preferred compute node identified as providing best probability of meeting required deadlines for RIP completion time of a raw sheetside.

Abstract: Methods, systems, and apparatus for improved dispatching of sheetsides in a high-speed (e.g., continuous form) printing environment using multiple, clustered processors in a print controller. Features and aspects hereof generate, update, and utilize a mathematical model of multiple processors (compute nodes) each adapted to RIP (rasterize) raw sheetside data provided to it. A head node or control processor receives the raw sheetside files from an attached host or server, determines current processing capacity of each of the multiple compute nodes to RIP the next sheetside, and dispatches the sheetside to the compute node identified as providing the minimum RIP completion time. Various conditions may invalidate a compute node from further consideration in dispatch of a particular sheetside. Thus a valid compute node is selected based on the minimum RIP completion time.

Abstract: An elutriation apparatus which combines pressurized liquid nozzles (16A) and the low energy air nozzles (20) producing bubbles for flotation and separation of trace materials in a heterogeneous mixture of materials is described. Quantitative separation of trace evidence is achieved by the apparatus by a closed system of mechanical separations using the water and the air to isolate and deposit trace evidence on a fine mesh screen filter (17) submerged in the water (24) in a container (23). The method provides a rapid, quantitative and inexpensive method for detection of the evidence in soil samples.