Abstract: Amino acid sequences and corresponding nucleic acid sequence of retinoid metabolizing protein found in human, mouse and zebrafish are described, as well as methods of using same.

Abstract: The present invention is directed to a method of assembling a container including an inner tube contained within an outer tube. The method includes providing an outer tube, providing a spacing element adjacent the open top of the outer tube and inserting an inner tube within the outer tube. The spacing element provides for venting of air from between the inner and outer tubes through the top of the container during assembly thereof.

Abstract: The present invention provides a novel all-trans-RA inducible all-trans-RA metabolizing cytochrome P450, P450RAI-2, that is predominantly expressed in the brain, cerebellum in particular. It is also expressed in normal and tumour lung tissue and in breast cancer cells and may have a correlation with lung and breast cancer. Human P450RAI-2 show 42% amino acid identity to human P450RAI-1 and when transfected into COS-1 cells causes the rapid conversion of all-trans-RA into more polar metabolites including the inactive products 4-oxo-RA, 4-OH-RA and 18-OH-RA. P450RAI-2, as with P450RAI-1, is also inducible in certain cultured cell lines exposed to all-trans-RA. Methods for and uses of the new polynucleotide, polypeptide, fragments thereof and inhibitors thereof, include the treatment of dermatological disorders, cancer and certain brain disorders.

Abstract: The present invention provides a novel all-trans-RA inducible all-trans-RA metabolizing cytochrome P450, P450RAI-2, that is predominantly expressed in the brain, cerebellum in particular. It is also expressed in normal and tumour lung tissue and in breast cancer cells and may have a correlation with lung and breast cancer. Human P450RAI-2 show 42% amino acid identity to human P450RAI-1 and when transfected into COS-1 cells causes the rapid conversion of all-trans-RA into more polar metabolites including the inactive products 4-oxo-RA, 4-OH-RA and 18-OH-RA. P450RAI-2, as with P450RAI-1, is also inducible in certain cultured cell lines exposed to all-trans-RA. Methods for and uses of the new polynucleotide, polypeptide, fragments thereof and inhibitors thereof, include the treatment of dermatological disorders, cancer and certain brain disorders.

Abstract: A method of assembling a container including an inner tube contained within an outer tube. The method includes providing an outer tube, providing a spacing element adjacent the open top of the outer tube and inserting an inner tube within the outer tube. The spacing element provides for venting of air from between the inner and outer tubes through the top of the container during assembly thereof.

Abstract: A stable, controlled release formulation for oral dosing of vitamin D compounds is disclosed. The formulation is prepared by incorporating one or more vitamin D compounds into a solid or semi-solid mixture of waxy materials. Oral dosage forms can be prepared by melt-blending the components described herein and filling gelatin capsules with the formulation.

Abstract: The present invention provides a novel all-trans-RA inducible all-trans-RA metabolizing cytochrome P450, P450RAI-2, that is predominantly expressed in the brain, cerebellum in particular. Human P450RAI-2 show 42% amino acid identity to human P450RAI-1 and when transfected into COS-1 cells causes the rapid conversion of all-trans-RA into more polar metabolites including the inactive products 4-oxo-RA, 4-OH-RA and 18-OH-RA. P450RAI-2, as with P450RAI-1, is also inducible in certain cultured cell lines exposed to all-trans-RA. Methods for and uses of the new polynucleotide, polypeptide, fragments thereof and inhibitors thereof, include the treatment of dermatological disorders and cancer.

Abstract: Amino acid sequences and corresponding nucleic acid sequence of retinoid metabolizing protein found in human, mouse and zebrafish are described, as well as methods of using same.

Abstract: A hubcap for a wheel end assembly of a heavy-duty vehicle seals an outboard end of the wheel end assembly. The wheel end assembly includes a wheel hub formed with a cavity that contains lubricant, and the hubcap positively engages and mounts on the outboard end of the wheel hub to prevent the escape of lubricant and the ingress of contaminants. The integrally-formed hubcap includes a generally cylindrical sidewall and an outboard wall that extends generally perpendicular to the sidewall. A lip extends inboardly from and a shoulder extends radially outwardly from an inboard end of the sidewall, and the lip and shoulder cooperate to positively mechanically engage the outboard end of the wheel hub. An O-ring is disposed between the lip and the wheel hub to provide a seal. The hubcap also is adapted to accommodate components of a tire inflation system and other auxiliary components.

Abstract: Amino acid sequences and corresponding nucleic acid sequence of retinoid metabolizing protein found in human, mouse and zebrafish are described, as well as methods of using same.

Abstract: Described is a triggering arrangement including a power supply, a lighting arrangement and a switch. The lighting arrangement is coupled to the power supply. The switch is coupled to the lighting arrangement and the power supply. When the switch is in a first position, the lighting arrangement generates light to a photo-sensing portable device. The device is situated a predetermined distance from the arrangement. The device initiates a predetermined action in response to the light.

Abstract: A cam shaft support/enclosure assembly for brake systems of heavy-duty vehicles is mounted on a beam of an axle/suspension system and includes a cam tube A bracket for mounting the cam tube on the beam includes a pair of plates that arc mounted on the beam. Each one of the plates is formed with an opening for receiving the cam tube and includes at least three tabs, and preferably four tabs, that extend outwardly from each respective plate adjacent the opening and contact the outer surface of the cam tube.

Abstract: A power pack with human interface devices that includes a power pack housing, which is detachably interfaced to a portable device. The power pack includes a power source internal to the housing for providing power, a light source internal to the housing for producing a light signal associated with a status, which light signal is viewable external to the housing, and an audio source internal to the housing for producing an audio signal associated with the status. The power pack interfaces electrically to the portable device to provide power thereto, and receive therefrom control signals associated with the status, which control signals activate at least one of the light source and audio source according to the status.

Abstract: An axle for a heavy-duty vehicle extends transversely across the vehicle and includes a central portion. Each one of a pair of relatively short and lightweight axle spindles is connected to and extends outboardly from a respective end of the axle central portion. A wheel end assembly is rotatably mounted on each axle spindle. Each wheel end assembly includes spaced-apart inboard and outboard bearings that are immovably mounted on a respective axle spindle, and the bearings preferably are standard heavy-duty vehicle stock-type bearings that have respective inner diameters that are generally the same size. A relatively short and lightweight wheel hub is rotatably mounted on the bearings so that the wheel end assembly selectively accommodates a dual-wheel, standard-tire configuration and a single-wheel, wide-tire configuration, including a two-inch offset wheel.

Abstract: A hubcap for a wheel end assembly of a heavy-duty vehicle seals an outboard end of the wheel end assembly. The wheel end assembly includes a wheel hub formed with a cavity that contains lubricant, and the hubcap positively engages and mounts on the outboard end of the wheel hub to prevent the escape of lubricant and the ingress of contaminants. The integrally-formed hubcap includes a generally cylindrical sidewall and an outboard wall that extends generally perpendicular to the sidewall. A lip extends inboardly from and a shoulder extends radially outwardly from an inboard end of the sidewall, and the lip and shoulder cooperate to positively mechanically engage the outboard end of the wheel hub. An O-ring is disposed between the lip and the wheel hub to provide a seal. The hubcap also is adapted to accommodate components of a tire inflation system and other auxiliary components.

Abstract: An axle for a heavy-duty vehicle extends transversely across the vehicle and includes a central portion. Each one of a pail of relatively short and lightweight axle spindles is connected to and extends outboardly from a respective end of the axle central portion. A wheel end assembly is rotatably mounted on each axle spindle. Each wheel end assembly includes spaced-apart inboard and outboard beatings that are immovably mounted on a respective axle spindle, and the bearings preferably ate standard heavy-duty vehicle stock-type bearings that have respective inner diameters that are generally the same size. The assembly optionally includes a bearing spacer having improved length tolerance. A relatively short and lightweight wheel hub is rotatably mounted on the bearings so that the wheel end assembly selectively accommodates a dual-wheel, standard-tire configuration and a single-wheel, wide-tire configuration, including a two-inch offset wheel.

Abstract: An axle spindle nut assembly secures a wheel end assembly on an axle spindle. The wheel end assembly includes outboard and inboard outboard bearings that are immovably mounted on the axle spindle, and a wheel hub which is rotatably mounting on the bearings. The spindle nut assembly includes a nut that threads onto an outboard end of the axle spindle, and is tightened against the outboard bearing to a selected torque level. The nut includes an outboard surface that is formed with a plurality of features. A washer is formed with a tab that engages a keyway of the axle spindle outboardly of the nut, and with a plurality of mating features that mechanically engage the features formed in the outboard surface of the nut to prevent substantial rotation of the nut after the nut has been tightened to the selected torque level.

Abstract: A method, system, and computer program product used for creating a custom footwear product. The method on which the system, and computer program product are based includes inputting in a retail store information about a characteristic of a consumer that relates to the consumer's foot, and receiving in the retail store a determination of a plurality of selected pre fabricated footwear components that have been selected based the information. Also included in the method is creating in the retail store a kit of prefabricated footwear components for the customer including the identified prefabricated footwear components to be assembled into the custom footwear product.

Abstract: A system for providing a shoe customized to a person includes a plurality of shoe cavity units each having an upper portion and a sole assembly coupled to the upper portion to form a shoe cavity configured to accommodate a foot. Also included is a plurality of interchangeable first shoe components each configured to be coupled to a shoe cavity unit and each configured to provide substantially the same first footwear function but having a different physical attribute based on differences among wearers, and a plurality of interchangeable second shoe components each configured to be coupled to a shoe cavity unit and each configured to provide substantially the same second footwear function but having a different physical attribute based on differences among wearers.

Abstract: A method for providing a custom shoe to a consumer, including identifying at least one characteristic about a consumer that is present within the retail store, the at least one characteristic relating to the consumer's foot. Also included is selecting a plurality of pre-fabricated footwear components based on the at least one characteristic, assembling the plurality of prefabricated footwear components into a custom shoe that is customized to the consumer, and presenting the custom shoe to the consumer before the customer leaves the retail store.