Patents by Inventor Jay-Do Choi

Jay-Do Choi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Modified E. coli enterotoxin II signal peptide and a microorganism expressing a fusion protein of a said peptide and a heterologous protein
    Patent number: 6605697
    Abstract: A heterologous protein is produced by: (i) culturing a microorganism transformed with an expression vector comprising a gene encoding a modified E. coli enterotoxin II signal peptide fused with the heterologous protein to produce and secrete the heterologous protein to periplasm, the modified E. coli enterotoxin II signal peptide being obtained by replacing at least one of the 2nd, 4th, 5th, 12th, 20th, and 22nd amino acids of E. coli enterotoxin II signal peptide of the following amino acid sequence (SEQ ID NO: 1) with another amino acid, with the proviso that at least one of the 2nd and 4th amino acid of the modified peptide is lysine; and (ii) recovering the heterologous protein from the periplasm.
    Type: Grant
    Filed: March 7, 2001
    Date of Patent: August 12, 2003
    Assignee: Hanmi Pharm. Co., Ltd.
    Inventors: Se-Chang Kwon, Sung-Youb Jung, Hoon Shin, Jay-Do Choi, Ki-Doo Choi, Gwan-Sun Lee