Patents by Inventor Jay E. Brenman

Jay E. Brenman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compounds Useful for the Treatment of Metabolic Disorders and Synthesis of the Same
    Publication number: 20180370905
    Abstract: The present invention provides compounds of Formula (I): wherein variables X, Y, Z and R1 are as described herein. Some of the compounds described herein are glutamate dehydrogenase activators. The invention is also directed to pharmaceutical compositions comprising these compounds, uses of these compounds and compositions in the treatment of metabolic disorders as well as synthesis of the compounds.
    Type: Application
    Filed: June 25, 2018
    Publication date: December 27, 2018
    Inventors: Jonathan Z. Sexton, Jay E. Brenman, David L. Musso
  • Compounds useful for the treatment of metabolic disorders and synthesis of the same
    Patent number: 10005720
    Abstract: The present invention provides compounds of Formula (I): wherein variables X, Y, Z and R1 are as described herein. Some of the compounds described herein are glutamate dehydrogenase activators. The invention is also directed to pharmaceutical compositions comprising these compounds, uses of these compounds and compositions in the treatment of metabolic disorders as well as synthesis of the compounds.
    Type: Grant
    Filed: April 4, 2014
    Date of Patent: June 26, 2018
    Assignees: North Carolina Central University, The University of North Carolina at Chapel Hill
    Inventors: Jonathan Z. Sexton, Jay E. Brenman, David L. Musso
  • High-Throughput Assay for Identifying Small Molecules that Modulate AMP-activated Protein Kinase (AMPK)
    Publication number: 20160176859
    Abstract: The present invention provides an in vitro method for identifying a compound that modulates adenosine monophosphate-activated protein kinase (AMPK) for the manufacture of a diagnostic or therapeutic agent. The present invention further provides an assay for identifying a compound that modulates AMPK.
    Type: Application
    Filed: February 10, 2016
    Publication date: June 23, 2016
    Inventors: Jonathan Z. Sexton, Jay E. Brenman
  • COMPOUNDS USEFUL FOR THE TREATMENT OF METABOLIC DISORDERS AND SYNTHESIS OF THE SAME
    Publication number: 20160046560
    Abstract: The present invention provides compounds of Formula (I): wherein variables X, Y, Z and R1 are as described herein. Some of the compounds described herein are glutamate dehydrogenase activators. The invention is also directed to pharmaceutical compositions comprising these compounds, uses of these compounds and compositions in the treatment of metabolic disorders as well as synthesis of the compounds.
    Type: Application
    Filed: April 4, 2014
    Publication date: February 18, 2016
    Inventors: Jonathan Z. Sexton, Jay E. Brenman, David L. Musso