Abstract: The present invention describes an antigen-binding construct comprising a first agent which binds to a stem cell specific marker molecule and a second agent which binds to a tissue specific marker molecule. In particular, the invention describes a construct wherein the tissue specific marker is a muscle specific marker molecule. Such a construct may be used in a pharmaceutical composition for use in muscle regeneration or heart disease.

Abstract: The present invention relates to methods for preventing or reducing the risk of mortality by any means including, but not limited to, cardiovascular events in mammals, particularly humans, comprising administering a dipeptidyl peptidase 4 (DPP-IV) inhibitor to the mammal or human. In addition, the present invention relates to methods for preventing or reducing the risk of non-fatal myocardial infarction and/or non-fatal stroke in mammals, particularly humans, comprising administering a DPP-IV inhibitor to the mammal or human.

Abstract: The invention provides compositions and methods for protecting vascular tissues from injury that occurs, for example, during occlusion of one or more arteries. In some embodiments, the injury is myocardial infarction. The compositions of the invention include combinations of platelet derived growth factor, vascular endothelial growth factor, and angiopoietin-2.

Abstract: The invention provides methods of treating and preventing loss of tissue vascularization that can occur, for example, upon aging.

Abstract: The invention relates to Tenascin-C and peptides that bind thereto. According to the invention, Tenascin-C or peptides and antibodies that bind thereto can be used to treat or prevent vascular diseases, either alone or in combination with therapeutic agents or cells that have cardioplastic potential.

Abstract: The present invention relates to peptides which selectively or preferentially home to areas of a heart. The invention further relates to conjugates of the homing peptides and uses thereof.

Abstract: The invention provides compositions and methods for protecting vascular tissues from injury that occurs, for example, during occlusion of one or more arteries. In some embodiments, the injury is myocardial infarction. The compositions of the invention include combinations of platelet derived growth factor, vascular endothelial growth factor, and angiopoietin-2.

Abstract: The present invention provides implantable physiological or pathophysiological biosensors. The subject biosensors comprise tissue or cells capable of carrying out a physiological or pathophysiological function, which can be used to monitor a chemical, physiological or pathophysiological variable associated with the physiological or pathophysiological function. In one embodiment, the tissue or cells are coupled via an electrical interface to an electronic measuring device or an electronic amplifying device. In another embodiment, the tissue or cells are coupled via an electrical interface to endogenous tissue or cells, including the blood. Preferably, the tissue or cells are excitable tissue or cells such as cardiac tissue or cells and neuronal tissue or cells. The subject biosensors may be placed, inserted or implanted in any animal including but not limited to a mouse, rat, rabbit, pig, cat, dog, cattle, horse, sheep or human.

Abstract: The invention provides methods of treating and preventing loss of tissue vascularization that can occur, for example, upon aging.