Abstract: Aspects presented herein may enhance the accuracy and/or latency of UE positioning based on crowd-sourcing, where a network entity may compute a position estimate of a UE based on neighbor-cell scan data from the UE and one or more reference UEs. In one aspect, a network entity receives a first set of measurements associated with at least one cell from a UE. The network entity performs a position estimation of the UE based on at least one of the first set of measurements associated with the at least one cell, a second set of measurements for each of a set of reference UEs, or a location of each of the set of reference UEs via an ML model, where the UE and the set of reference UEs include at least one common cell.

Abstract: The present invention relates to a method for producing a plurality of homogeneous neurospheres, said method comprising: providing pluripotent cells; seeding said pluripotent cells into a cell culture device comprising at least one compartment comprising a plurality of microwells; and culturing said pluripotent cells in said cell culture device under conditions that allow the cells to form neurospheres.

Abstract: The present invention relates to 3D brain organoids, uses thereof, methods and culture medium for generating such organoids. An aspect of the invention provides brain organoids and methods of generating such organoids with bilaterally symmetric optic vesicles, containing both neuronal and non-neuronal cell types, and exhibiting functional circuitry. These organoids can be generated within short time intervals (e.g., 50 days) and therefore are useful for medical modelling and applications.

Abstract: The invention relates to CPAP-tubulin inhibitors having the general formula (1) or a physiologically acceptable salt thereof; and their use as cancer therapeutics.

Abstract: The invention relates to CPAP-tubulin inhibitors having the general formula (1) or a physiologically acceptable salt thereof; and their use as cancer therapeutics.