Patents by Inventor Jay Grobler

Jay Grobler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method to confer cell culture replication activity to different Hepatitis C virus isolates
    Patent number: 7807455
    Abstract: The present invention features methods for producing HCV replicons using HCV encoding sequences from different isolates. The featured methods are based on the discovered importance of NS3 amino acid position 470 in conferring cell culture replication activity to different HCV isolates.
    Type: Grant
    Filed: February 9, 2004
    Date of Patent: October 5, 2010
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Jay Grobler, Osvaldo Flores, Eric J. Markel
  • Hepatitis C virus assay systems
    Patent number: 7786287
    Abstract: The present invention features assays employing a beta-lactamase reporter system, an HCV replicon enhanced cell, and/or a chimeric HCV replicon containing a 3? UTR based on the HCV-1a 3? UTR. These features can be employed alone or together, and are preferably combined together to measure HCV replicon activity and the affect of compounds on such activity.
    Type: Grant
    Filed: April 11, 2003
    Date of Patent: August 31, 2010
    Assignee: Merck & Co., Inc.
    Inventors: Osvaldo A. Flores, Jay Grobler, Edward M. Murray, Paul D. Zuck
  • Method to confer cell culture replication activity to different hepatitis c virus isolates
    Publication number: 20060228697
    Abstract: The present invention features methods for producing HCV replicons using HCV encoding sequences from different isolates. The featured methods are based on the discovered importance of NS3 amino acid position 470 in conferring cell culture replication activity to different HCV isolates.
    Type: Application
    Filed: February 9, 2004
    Publication date: October 12, 2006
    Inventors: Jay Grobler, Osvaldo Flores, Eric Markel
  • Hepatitis c virus assay systems
    Publication number: 20050181356
    Abstract: The present invention features assays employing a beta-lactamase reporter system, an HCV replicon enhanced cell, and/or a chimeric HCV replicon containing a 3? UTR based on the HCV-1a 3? UTR.
    Type: Application
    Filed: April 11, 2003
    Publication date: August 18, 2005
    Inventors: Osvaldo Flores, Jay Grobler, Edward Murray, Paul Zuck