Patents by Inventor Jay H. Kalin

Jay H. Kalin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and compositions involving RAD51 inhibitors
    Patent number: 10912761
    Abstract: The present invention concerns methods and compositions involving inhibitors and of RAD51, a protein involved in homologous recombination. In some embodiments, there are methods for sensitizing cells to the effects of DNA damaging agents, which can have particular applications for cancer patients. In some embodiments of the invention, the RAD51 inhibitor is a small molecule that directly affects RAD51 activity, such as its ability to promote filament formation.
    Type: Grant
    Filed: November 27, 2013
    Date of Patent: February 9, 2021
    Assignee: THE UNIVERSITY OF CHICAGO
    Inventors: Philip P. Connell, Brian Budke, Jay H. Kalin, Michal Pawlowski, Alan P. Kozikowski
  • HDAC inhibitors and therapeutic methods using the same
    Patent number: 9249087
    Abstract: Histone deacetylases inhibitors (HDACIs) and compositions containing the same are disclosed. Methods of treating diseases and conditions wherein inhibition of HDAC provides a benefit, like a cancer, a neurodegenerative disorder, a peripheral neuropathy, a neurological disease, traumatic brain injury, stroke, hypertension, malaria, an autoimmune disease, autism, autism spectrum disorders, and inflammation, also are disclosed.
    Type: Grant
    Filed: January 31, 2012
    Date of Patent: February 2, 2016
    Assignees: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS, THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Alan Kozikowski, Jay H. Kalin, Kyle V. Butler, Joel Bergman, Wayne W. Hancock
  • METHODS AND COMPOSITIONS INVOLVING RAD51 INHIBITORS
    Publication number: 20150306069
    Abstract: The present invention concerns methods and compositions involving inhibitors and of RAD51, a protein involved in homologous recombination. In some embodiments, there are methods for sensitizing cells to the effects of DNA damaging agents, which can have particular applications for cancer patients. In some embodiments of the invention, the RAD51 inhibitor is a small molecule that directly affects RAD51 activity, such as its ability to promote filament formation.
    Type: Application
    Filed: November 27, 2013
    Publication date: October 29, 2015
    Applicant: THE UNIVERSITY OF CHICAGO
    Inventors: Philip P. Connell, Brian Budke, Jay H. Kalin, Michal Pawlowski, Alan P. Kozikowski
  • HDAC INHIBITORS AND THERAPEUTIC METHODS USING THE SAME
    Publication number: 20140128408
    Abstract: Histone deacetylases inhibitors (HDACIs) and compositions containing the same are disclosed. Methods of treating diseases and conditions wherein inhibition of HDAC provides a benefit, like a cancer, a neurodegenerative disorder, a peripheral neuropathy, a neurological disease, traumatic brain injury, stroke, hypertension, malaria, an autoimmune disease, autism, autism spectrum disorders, and inflammation, also are disclosed.
    Type: Application
    Filed: January 31, 2012
    Publication date: May 8, 2014
    Applicant: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
    Inventors: Alan Kozikowski, Jay H. Kalin, Kyle V. Butier, Joel Bergman, Wayne W. Hancock
  • HDAC inhibitors and therapeutic methods of using same
    Patent number: 8431538
    Abstract: Histone deacetylases inhibitors (HDACIs) and compositions containing the same are disclosed. Methods of treating diseases and conditions wherein inhibition of HDAC provides a benefit, like a cancer, a neurodegenerative disorder, a neurological disease, traumatic brain injury, stroke, malaria, an autoimmune disease, autism, and inflammation, also are disclosed.
    Type: Grant
    Filed: July 2, 2010
    Date of Patent: April 30, 2013
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Alan Kozikowski, Kyle V. Butler, Jay H. Kalin
  • HDAC INHIBITORS AND THERAPEUTIC METHODS OF USING SAME
    Publication number: 20120252740
    Abstract: Histone deacetylases inhibitors (HDACIs) and compositions containing the same are disclosed. Methods of treating diseases and conditions wherein inhibition of HDAC provides a benefit, like a cancer, a neurodegenerative disorder, a neurological disease, traumatic brain injury, stroke, malaria, an autoimmune disease, autism, and inflammation, also are disclosed.
    Type: Application
    Filed: July 2, 2010
    Publication date: October 4, 2012
    Inventors: Alan Kozikowski, Kyle V. Butler, Jay H. Kalin