Abstract: In some aspects, fusosome compositions and methods are described herein that comprise membrane enclosed preparations, comprising a fusogen. In some embodiments, the fusosome can fuse to the target cell, thereby delivering complex biologic agents to the target cell cytoplasm.

Abstract: Fusosome compositions and methods are described herein.

Abstract: In some aspects, fusosome compositions and methods are described herein that comprise membrane enclosed preparations, comprising a fusogen. In some embodiments, the fusosome can the target cell, thereby delivering complex biologic agents to the target cell cytoplasm.

Abstract: The present disclosure provides, at least in part, methods and compositions for in vivo fusosome delivery. In some embodiments, the fusosome comprises a combination of elements that promote specificity for target cells, e.g., one or more of a re-targeted fusogen, a positive target cell-specific regulatory element, and a non-target cell-specific regulatory element. In some embodiments, the fusosome comprises one or more modifications that decrease an immune response against the fusosome.

Abstract: This disclosure provides, e.g., cytobiologic compositions and methods of use thereof. The cytobiologics can be used, e.g., to deliver a protein or nucleic acid to a target cell.

Abstract: Fusosome compositions and methods are described herein.

Abstract: A method and an apparatus for providing a configurable, object-oriented, protocol-neutral interface between a physical device and a server. The method includes coupling an application gateway with the physical device, where the application gateway includes a protocol gateway module configured for physical communication with the physical device, and an object adapter module configured for virtual communication between the physical device and a client application running on a server. The method further includes configuring a service starter to launch and bind the object adapter module with the protocol gateway module, configuring the protocol gateway module to define the physical interface between the physical device and the protocol gateway, and establishing communication between the protocol gateway module and the physical device, such that the physical device is exposed as a network device on the server.

Abstract: In some aspects, fusosome compositions and methods are described herein that comprise membrane enclosed preparations, comprising a fusogen. In some embodiments, the fusosome can the target cell, thereby delivering complex biologic agents to the target cell cytoplasm.

Abstract: Systems and methods for synchronizing data between a database system and its client applications are provided. After a regular synchronization, objects' records on a user computing device may be checked against a new sharing rule. Newly shared records may be synced down to the user computing device regardless of timestamps, and all records which the user no longer has access to may be removed from the user computing device. Consequently, data on the user computing device complies with the new sharing rule.

Abstract: Systems and methods for managing, integrating and synchronizing data from a number of different sources for an enterprise. A Master Data Management (“MDM”) system may be used to hold and manage the enterprise's data, and a data integration server may be used to facilitate communications between the MDM system and other data sources, e.g., a CRM. The MDM system may store the enterprise's data as customer master data, which may include data from the enterprise's internal sources, data from the MDM provider, data from other data providers, and a Golden Record consolidated from such data. A data steward service may be used to maintain the customer master data and make it accurate and up-to-date. Users may directly search the customer master data in the MDM system, and may also update the CRM with the customer master data.

Abstract: Systems and methods for managing, integrating and synchronizing data from a number of different sources for an enterprise. A Master Data Management (“MDM”) system may be used to hold and manage the enterprise's data, and a data integration server may be used to facilitate communications between the MDM system and other data sources, e.g., a CRM. The MDM system may store the enterprise's data as customer master data, which may include data from the enterprise's internal sources, data from the MDM provider, data from other data providers, and a Golden Record consolidated from such data. A data steward service may be used to maintain the customer master data and make it accurate and up-to-date. Users may directly search the customer master data in the MDM system, and may also update the CRM with the customer master data.

Abstract: Systems and methods for synchronizing data between a database system and its client applications are provided. After a regular synchronization, objects' records on a user computing device may be checked against a new sharing rule. Newly shared records may be synced down to the user computing device regardless of timestamps, and all records which the user no longer has access to may be removed from the user computing device. Consequently, data on the user computing device complies with the new sharing rule.

Abstract: A method and an apparatus for providing a configurable, object-oriented, protocol-neutral interface between a physical device and a server. The method includes coupling an application gateway with the physical device, where the application gateway includes a protocol gateway module configured for physical communication with the physical device, and an object adapter module configured for virtual communication between the physical device and a client application running on a server. The method further includes configuring a service starter to launch and bind the object adapter module with the protocol gateway module, configuring the protocol gateway module to define the physical interface between the physical device and the protocol gateway, and establishing communication between the protocol gateway module and the physical device, such that the physical device is exposed as a network device on the server.

Abstract: A method and a system for the off site monitoring/diagnostics, command/control, alarm/event management, historical/trend analysis, and configuration/administration of building automation systems through an event manager for use in a facilities monitoring system having network-level and protocol-neutral communication with a physical device. The method includes managing a non internet protocol-based physical device, including coupling a device gateway with the physical device, wherein the device gateway is configured to expose the physical device as a networked device on a server. The method also includes receiving event information from the coupled physical device, wherein the event information includes an event and a device identifier; responsive to a determination that the event information includes an actionable event, processing the event, the device identifier, and the actionable event to determine a responsible process; and notifying the responsible process of the event.

Abstract: A method and an apparatus for providing a configurable, object-oriented, protocol-neutral interface between a physical device and a server. The method includes coupling an application gateway with the physical device, where the application gateway includes a protocol gateway module configured for physical communication with the physical device, and an object adapter module configured for virtual communication between the physical device and a client application running on a server. The method further includes configuring a service starter to launch and bind the object adapter module with the protocol gateway module, configuring the protocol gateway module to define the physical interface between the physical device and the protocol gateway, and establishing communication between the protocol gateway module and the physical device, such that the physical device is exposed as a network device on the server.

Abstract: Methods and systems for managing personal needs are provided. In particular, the present invention relates to an personal assistance program enabled via a communication network. An individual's needs are fulfilled via a customized Resource Center created in response to the individual's inquiry. The Resource Center may be in the form of a personalized web page created for the individual by a specialist in response to the inquiry. The Resource Center may contain specific educational materials relating to the particular need in question, as well as personalized referral information relating to providers qualified by the specialist for the individual. The specialists are provided to assist individuals with virtually all aspects of daily life, including but not limited to child care, pet care, education, employee benefits, health care, elder care, pregnancy, finance, personal problem solving, time management, or the like.