Abstract: The present invention relates to MLL fusion proteins (e.g., AF9 and ENL), which activate target genes in part via recruitment of histone methyltransferase DOT1L. In particular, the present invention provides the AF9/ENL binding site in DOT1L and agents that block the protein-protein interactions between AF9/ENL and DOT1L, therefore inhibiting the activity of DOT1L, and inhibiting MLL-fusion protein associated leukemia.

Abstract: The present disclosure relates generally to thienopyrimidine and thienopyridine compounds and methods of use thereof. In particular embodiments, the present disclosure provides compositions comprising thienopyrimidine and thienopyridine compounds of Formula 4b: and methods of use to inhibit the interaction of menin with MLL1, MLL2 and MLL-fusion oncoproteins.

Abstract: The invention relates generally to effective treatment leukemia. In particular, the present invention provides compositions and methods to inhibit the interaction of menin with MLL and MLL-fusion oncoproteins, and well as systems and methods to screen for such compositions.

Abstract: The present invention relates generally to thienopyrimidine and thienopyridine class compounds and methods of use thereof. In particular embodiments, the present invention provides compositions comprising thienopyrimidine and thienopyridine class compounds and methods of use to inhibit the interaction of menin with MLL1, MLL2 and MLL-fusion oncoproteins (e.g., for the treatment of leukemia, solid cancers and other diseases dependent on activity of MLL1, MLL2, MLL fusion proteins, and/or menin).

Abstract: The present invention relates to MLL fusion proteins (e.g., AF9 and ENL), which activate target genes in part via recruitment of histone methyltransferase DOT1L. In particular, the present invention provides the AF9/ENL binding site in DOT1L and agents that block the protein-protein interactions between AF9/ENL and DOT1L, therefore inhibiting the activity of DOT1L, and inhibiting MLL-fusion protein associated leukemia.

Abstract: The invention relates generally to effective treatment leukemia. In particular, the present invention provides compositions and methods to inhibit the interaction of menin with MLL and MLL-fusion oncoproteins, and well as systems and methods to screen for such compositions.

Abstract: A tow bar having a towing portion with multiple interchangeable towing assemblies each structured to be releasably connectable to towing vehicles having different types and/or sizes of towing hitch apparatus; a towed portion with a body member connected to a pair of rearwardly-extending legs each with a rear connector releasably connectable to a baseplate connector of a towed hitch apparatus of a towed vehicle, at least one of the legs being pivotally connected to the body member; an attaching portion structured to releasably connect each interchangeable towing assembly to the body member; and a storage mechanism structured to releasable secure the tow bar to a baseplate connector of the towed hitch apparatus of the towed vehicle.

Abstract: The invention relates generally to effective treatment leukemia. In particular, the present invention provides compositions and methods to inhibit the interaction of menin with MLL and MLL-fusion oncoproteins, and well as systems and methods to screen for such compositions.

Abstract: A torsionally-biased, shock-absorbing fifth wheel hitch includes a first mounting mechanism removably and non-rotatably mounting a lower frame portion thereof to the bed of a towing vehicle; an upper frame portion; a second mounting mechanism with a pair of opposing resilient members pivotally mounting the upper frame portion about a horizontally-oriented transverse hitch axis relative to the lower frame portion, the second mounting mechanism having an inactivated configuration wherein the upper frame member is not pivotally biased about the transverse hitch axis relative to the lower frame member and an activated configuration wherein the upper frame member is pivotally biased about the transverse hitch axis relative to the lower frame member; and a fifth wheel hitch mechanism mounted to the upper frame portion.

Abstract: A converter apparatus for connecting a fifth wheel-type trailer to a towing vehicle having a ball hitch extending above a bed thereof, the apparatus including a horizontal first body member; a clamping mechanism releasably securing the first body member to the ball hitch; a mounting member having a horizontal second body member fixedly secured perpendicularly to and above the first body member, a pair of horizontal arm members perpendicular to and extending adjustably outwardly from opposing ends of the second body member, and a pair of horizontal arm extension members extending adjustably outwardly from opposing ends of each of the arm members; a fifth wheel hitch mechanism; and securing mechanisms releasably securing the fifth wheel hitch mechanism to the arm extension members of the arm members.