Patents by Inventor Jay K. Seyler

Jay K. Seyler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 4820804
    Abstract: New hypocalcaemic peptides are disclosed of the formula ##STR1## wherein X represents H for the replacement of the N alpha amino group or acyl groups for the acylation of the N alpha amino group, the N-alpha amino group. The acyl groups are carboxylic acids especially formic, acetic, propionic, buteric, valeric, hexanoic, heptanoic, octanoic, and nonanoic acids or their respective isomers, L-lactic acid and the half amides of malonic, succinic, glutaric and adipic acids. Y is L-valine, glycine, L-methionine, L-alanine, L-leucine or L-isoleucine.
    Type: Grant
    Filed: April 21, 1987
    Date of Patent: April 11, 1989
    Assignee: Rorer Pharmaceutical Corporation
    Inventors: Ronald C. Orlowski, Jay K. Seyler, James E. Geever, Everett Flanigan
  • Patent number: 4764590
    Abstract: New peptides are disclosed which have biological activity of the same type as known calcitonins and which do not have a leucine in position 19, a glutamine in position 20, or a threonine in position 21. All three amino acids are omitted. Also resin peptides are disclosed which may be converted to peptides having such biological activity; and processes for producing said resin peptides and said calcitonin peptides.
    Type: Grant
    Filed: April 21, 1987
    Date of Patent: August 16, 1988
    Assignee: Rorer Pharmaceutical Corporation
    Inventors: Ronald C. Orlowski, Jay K. Seyler
  • Patent number: 4764589
    Abstract: New hypocalcaemic peptides are disclosed of the formula ##STR1## wherein X represents acyl groups for the acylation of the N alpha-amino group and the radicals of carboxylic acids especially of formic, acetic, propionic, buteric, valeric, hexanoic, heptanoic, octanoic, and nonanoic acids along with all their respective isomers. We also wish to include L-lactic acid along with the half amides of malonic, succinic, glutaric and adipic acids.
    Type: Grant
    Filed: May 26, 1987
    Date of Patent: August 16, 1988
    Assignee: Rorer Pharmaceutical Corporation
    Inventors: Ronald C. Orlowski, Jay K. Seyler
  • Patent number: 4764591
    Abstract: New peptides are disclosed which have biological activity of the same type as known calcitonins and which do not have a leucine in position 19, a glutamine in position 20, a threonine in position 21, and a tyrosine in position 22. All four amino acids are omitted. Also resin peptides are disclosed which may be converted to peptides having such biological activity; and processes for producing said resin peptides and said calcitonin peptides.
    Type: Grant
    Filed: April 21, 1987
    Date of Patent: August 16, 1988
    Assignee: Rorer Pharmaceutical Corporation
    Inventors: Ronald C. Orlowski, Jay K. Seyler, Everett Flanigan
  • Patent number: 4746728
    Abstract: New peptides are disclosed which have biological activity of the same type as the known calcitonins and which have a glycine at position 8 instead of the natural valine found in that position. In addition these new peptides do not have a leucine in position 19. The position 19 leucine is omitted. Also resin peptides are disclosed which may be converted to peptides having such biological activity; and processes for producing said resin peptides and said calcitonin peptides.
    Type: Grant
    Filed: May 5, 1986
    Date of Patent: May 24, 1988
    Assignee: Armour Pharmaceutical Company
    Inventors: Ronald C. Orlowski, Jay K. Seyler
  • Patent number: 4732969
    Abstract: New peptides are disclosed which have biological activity of the same type as known calcitonins and which do not have a leucine in position 19 or a glutamine in position 20. Both amino acids are omitted. Also resin peptides are disclosed which may be converted to peptides having such biological activity; and processes for producing said resin peptides and said calcitonin peptides.
    Type: Grant
    Filed: May 5, 1986
    Date of Patent: March 22, 1988
    Assignee: Armour Pharmaceutical Corporation
    Inventors: Ronald C. Orlowski, Jay K. Seyler, James E. Geever
  • Patent number: 4659804
    Abstract: New peptides are disclosed which have biological activity of the same type as known calcitonins and which do not have a disulfide bond connecting the cysteines at positions one and seven. Also resin peptides are disclosed which may be converted to peptides having such biological activity; and processes for producing said resin peptides and said calcitonin partially protected peptides.
    Type: Grant
    Filed: November 1, 1984
    Date of Patent: April 21, 1987
    Assignee: Armour Pharmaceutical Company
    Inventors: Ronald C. Orlowski, Jay K. Seyler, Robert L. Colescott, Glenn L. Stahl, Takashi Enkoji, James E. Geever, Everett Flanigan
  • Patent number: 4639510
    Abstract: New peptides are disclosed which have biological activity of the same type as known calcitonins and which have an S-acetamidomethyl cysteine at one and an alanine at seven, or an alanine at one and an S-acetamidomethyl cysteine at seven. Also resin peptides are disclosed which may be converted to peptides having such biological activity; and processes for producing said resin peptides and said calcitonin-type peptides.
    Type: Grant
    Filed: October 4, 1985
    Date of Patent: January 27, 1987
    Assignee: Armour Pharmaceutical Company
    Inventors: Ronald C. Orlowski, Jay K. Seyler, Glenn L. Stahl
  • Patent number: 4639511
    Abstract: New peptides are disclosed which have biological activity of the same type as known calcitonins and which do not have a leucine in position 19. The position 19 leucine is omitted. Also resin peptides are disclosed which may be converted to peptides having such biological activity; and processes for producing said resin peptides and said calcitonin peptides.
    Type: Grant
    Filed: November 12, 1985
    Date of Patent: January 27, 1987
    Assignee: Armour Pharmaceutical Company
    Inventors: Ronald C. Orlowski, Jay K. Seyler
  • Patent number: 4632978
    Abstract: New peptides are disclosed which have biological activity of the same type as known calcitonins; which have a serine in position 6 while the position 19 leucine is omitted. Also resin peptides are disclosed which may be converted to peptides having such biological activity; and processes for producing said resin peptides and said calcitonin peptides.
    Type: Grant
    Filed: October 15, 1985
    Date of Patent: December 30, 1986
    Assignee: Armour Pharmaceutical Corp.
    Inventors: Jay K. Seyler, Ronald C. Orlowski
  • Patent number: 4622386
    Abstract: New peptides are disclosed which have biological activity of the same type as known calcitonins and which do not have cysteines at positions one and seven. Also resin peptides are disclosed which may be converted to peptides having such biological activity; and processes for producing said resin peptides and said calcitonin-type peptides.
    Type: Grant
    Filed: March 28, 1985
    Date of Patent: November 11, 1986
    Assignee: Armour Pharmaceutical Company
    Inventors: Ronald C. Orlowski, Jay K. Seyler, Glenn L. Stahl
  • Patent number: 4622387
    Abstract: New peptides are disclosed which have biological activity of the same type as known calcitonins and which have an methionine in position 8 instead of the natural valine found in that position. Also resin peptides are disclosed which may be converted to peptides having such biological activity; and processes for producing said resin peptides and said calcitonin peptides.
    Type: Grant
    Filed: June 19, 1985
    Date of Patent: November 11, 1986
    Assignee: Armour Pharmaceutical Co.
    Inventors: Ronald C. Orlowski, Jay K. Seyler
  • Patent number: 4622388
    Abstract: New peptides are disclosed which have biological activity of the same type as known calcitonins and which do not have a serine in position 2 nor an asparagine in position 3. Both serine 2 and asparagine 3 are omitted. Also resin peptides are disclosed which may be converted to peptides having such biological activity; and processes for producing said resin peptides and said calcitonin peptides.
    Type: Grant
    Filed: November 12, 1985
    Date of Patent: November 11, 1986
    Assignee: Armour Pharmaceutical Company
    Inventors: Ronald C. Orlowski, Jay K. Seyler
  • Patent number: 4606856
    Abstract: New peptides are disclosed which have biological activity of the same type as known calcitonins and do not have an amino group on cysteine one and also are substitution analogs of the natural calcitonins. Also resin peptides are disclosed which may be converted to peptides having such biological activity; and processes for producing said resin peptides and said calcitonin peptides.
    Type: Grant
    Filed: March 18, 1985
    Date of Patent: August 19, 1986
    Inventors: Jay K. Seyler, Ronald C. Orlowski
  • Patent number: 4605514
    Abstract: New peptides are disclosed which have biological activity of the same type as known calcitonins and which do not have a leucine in position 4. The position 4 leucine is omitted. Also resin peptides are disclosed which may be converted to peptides having such biological activity; and processes for producing said resin peptides and said calcitonin peptides.
    Type: Grant
    Filed: September 24, 1984
    Date of Patent: August 12, 1986
    Assignee: Armour Pharmaceutical Company
    Inventors: Ronald C. Orlowski, Jay K. Seyler, Glenn L. Stahl
  • Patent number: 4604237
    Abstract: New peptides are disclosed which have biological activity of the same type as known calcitonins and which do not have a threonine in position 21. The position 21 threonine is omitted. Also resin peptides are disclosed which may be converted to peptides having such biological activity; and processes for producing said resin peptides and said calcitonin peptides.
    Type: Grant
    Filed: November 20, 1984
    Date of Patent: August 5, 1986
    Assignee: Armour Pharmaceutical Company
    Inventors: Ronald C. Orlowski, Jay K. Seyler, Glenn L. Stahl
  • Patent number: 4604236
    Abstract: New peptides are disclosed which have biological activity of the same type as known calcitonins and which do not have a serine in position 13. The position 13 serine is omitted. Also resin peptides are disclosed which may be converted to peptides having such biological activity; and processes for producing said resin peptides and said calcitonin peptides.
    Type: Grant
    Filed: March 18, 1985
    Date of Patent: August 5, 1986
    Inventors: Ronald C. Orlowski, Jay K. Seyler
  • Patent number: 4604238
    Abstract: New peptides are disclosed which have biological activity of the same type as known calcitonins and which have a shorter amino acid chain than natural calcitonins and are also substitution analogs of the natural calcitonins. Also resin peptides are disclosed which may be converted to peptides having such biological activity; and processes for producing said resin peptides and said calcitonin peptides.
    Type: Grant
    Filed: December 10, 1984
    Date of Patent: August 5, 1986
    Assignee: Armour Pharmaceutical Company
    Inventors: Ronald C. Orlowski, Jay K. Seyler, Glenn L. Stahl
  • Patent number: 4597900
    Abstract: New peptides are disclosed which have biological activity of the same type as known calcitonins and which have a shorter amino acid chain than natural calcitonins and are also substitution analogs of the natural calcitonins. Also resin peptides are disclosed which may be converted to peptides having such biological activity; and processes for producing said resin peptides and said calcitonin peptides.
    Type: Grant
    Filed: August 22, 1983
    Date of Patent: July 1, 1986
    Assignee: Armour Pharmaceutical Co.
    Inventors: Ronald C. Orlowski, Jay K. Seyler
  • Patent number: 4537716
    Abstract: New peptides are disclosed which have biological activity of the same type as known calcitonins and which have a shorter amino acid chain than natural calcitonins and are also substitution analogs of the natural calcitonins. Also resin peptides are disclosed which may be converted to peptides having such biological activity; and processes for producing said resin peptides and said calcitonin peptides.
    Type: Grant
    Filed: December 5, 1983
    Date of Patent: August 27, 1985
    Assignee: Armour Pharmaceutical Co.
    Inventors: Ronald C. Orlowski, Jay K. Seyler