Abstract: The present invention relates to methods of preventing and/or treating necrotizing enterocolitis or other intestinal inflammations using an IL-22, a dimer or a multimer thereof.

Abstract: The present invention relates to methods of preventing and/or treating necrotizing enterocolitis or other intestinal inflammations using an IL-22, a dimer or a multimer thereof.

Abstract: Pneumonia due to the fungus Pneumocystis jirovecii is a life-threatening infection that occurs in immunocompromised patients. The inability to culture the organism as well as the lack of a sequenced genome has hindered antigen discovery that could be useful in developing effective vaccines, therapeutic antibodies and diagnostic methods. A method of surface proteomics of Pneumocystis murina that reliably detects surface proteins that are conserved in Pneumocystis jirovecii is described. In particular, eight identified P. murina surface proteins are described. Methods of eliciting immune responses against the identified proteins, generating therapeutic antibodies against the identified proteins, as well as diagnostic methods based on the identified peptides are described.

Abstract: A prototype management system to provide cross team tools, frameworks, prototype management, and prototype tracking capabilities to improve the overall timeliness and quality of application and web-based product development. In an example, the prototype management system may be configured to cause the prototype to act as a live website that may be accessed by each of the teams and causes each team member to develop operable objects opposed to simulated objects.

Abstract: A prototype management system to provide cross team tools, frameworks, prototype management, and prototype tracking capabilities to improve the overall timeliness and quality of application and web-based product development. In an example, the prototype management system may be configured to cause the prototype to act as a live website that may be accessed by each of the teams and causes each team member to develop operable objects opposed to simulated objects.

Abstract: Pneumonia due to the fungus Pneumocystis jirovecii is a life-threatening infection that occurs in immunocompromised patients. The inability to culture the organism as well as the lack of a sequenced genome has hindered antigen discovery that could be useful in developing effective vaccines, therapeutic antibodies and diagnostic methods. A method of surface proteomics of Pneumocystis murina that reliably detects surface proteins that are conserved in Pneumocystis jirovecii is described. In particular, eight identified P. murina surface proteins are described. Methods of eliciting immune responses against the identified proteins, generating therapeutic antibodies against the identified proteins, as well as diagnostic methods based on the identified peptides are described.

Abstract: The manufacture of cellular product such as a protein by expression from a cell line in a bioreactor is carried out wherein the bioreactor is a container made of flexible film, at least the interior surface of the container being fluoropolymer, and in addition, the nutrient medium and other agents used in the fermentation or cell culture process can be prepared in a separate container of the same film.

Abstract: A process for the production of therapeutic protein is provided, which includes the steps of preparing nutrient medium for culturing of cells to express the protein, culturing the cells in the presence of the nutrient medium to express the protein, preparing protein separation solution for isolating the protein, formulating the isolated protein, and storing the formulated protein, at least three of these steps being carried out in separate disposable containers made of flexible film, at least the interior of said surface of said container being made of fluoropolymer.

Abstract: A package is provided, comprising a fluoropolymer bag and an overwrap, the package being terminally sterilized so as to obtain and maintain the sterilization condition of the fluoropolymer bag, which can then be made available as a sterilized, disposable vessel for biological material and corrosive reagents.

Abstract: Therapeutic protein is formulated in a container made of flexible film, at least the interior surface of said container being fluoropolymer, which is preferably terminally sterilized in a sealed overwrap so as to be available for the formulating step in sterilized condition.

Abstract: A flexible container is provided of flexible film, the interior surface of the container being fluoropolymer, the container being applicable to the storage and/or preparation of protein separation solution used in the chromatographic purification of protein, such as therapeutic protein.

Abstract: A pelvic traction harness including a circumferential belt that is adapted to be secured around the torso of a patient and has a first end, a second end and a posterior area intermediate the first end and the second end. The harness also includes a separate cinching strap belt that is adapted to be secured around the circumferential belt and has a male end, a female end and an anterior region intermediate the male end and the female end. The harness also includes a pulling strap having an anterior end and a posterior end, said anterior end being adapted to be attached to anterior region of the cinching strap belt, said posterior end being adapted to be attached to the posterior area of the circumferential belt. The pulling strap is also adapted to extend between the legs of the patient and attach to a source for applying a pulling force. The invention also includes a method for applying a traction force to the spine of a patient through the pelvic region of the patient.

Abstract: A multiply paper structure having at least one ply containing a mixture of cellulose ester fibers and cellulose fibers, having improved softening properties, readily moldable at moderate temperatures, printable with ordinary inks, and having adequate stiffness for applications requiring a desired stiffness, and a process for making the same.

Abstract: A high pressure laminate is made of several layers of paper, including from bottom to top core sheets, a decor sheet and an overlay sheet. The core sheets are either composed of cellulose fibers or composed of 30 to 90 weight percent cellulose acetate fibers and 70 to 10 weight percent cellulose fibers. The core sheets are respectively coated with either a lamination polymer or a plasticizer. The decor sheet is composed of a mixture and a conventional amount of paper making dye. The mixture comprises 30 to about 90 weight percent cellulose acetate fibers, 10 to 70 weight percent cellulose fibers and 0 to 20 weight percent fillers. The decor sheet is coated with a plasticizer. The overlay sheet is composed of cellulose fibers and is coated with a lamination polymer. Upon application of heat and pressure to the several layers a laminate is formed having thermoplastic properties, improved postformability and a significant reduction in the release of volatile organics during formation.

Abstract: A decorative paper sheet for use in preparing a decorative laminate is made up of a matrix containing from about 15 to about 60 weight percent of cellulose and from about 40 to about 85 weight percent of cellulose acetate. The sheet also contains a plasticizer for the cellulose acetate in an amount ranging from about 40 to about 90 weight percent based on the weight of the cellulose acetate in said matrix. A filler material may be present in the sheet in an amount ranging from about 1 to about 18 weight percent based on the weight of the matrix. A low pressure laminate may be made from sheet and a structural substrate therefor by application of heat and pressure. The plasticized cellulose acetate fuses and resolidifies to bond the sheet to the structural substrate.

Abstract: A high pressure laminate is made of several layers of paper, including from bottom to top core sheets, a decor sheet and an overlay sheet. The core sheets are either composed of cellulose fibers or composed of 30 to 90 weight percent cellulose acetate fibers and 70 to 10 weight percent cellulose fibers. The core sheets are respectively coated with either a lamination polymer or a plasticizer. The decor sheet is composed of a mixture and a conventional amount of paper making dye. The mixture comprises 30 to about 90 weight percent cellulose acetate fibers, 10 to 70 weight percent cellulose fibers and 0 to 20 weight percent fillers. The decor sheet is coated with a plasticizer. The overlay sheet is composed of cellulose fibers and is coated with a lamination polymer. Upon application of heat and pressure to the several layers a laminate is formed having thermoplastic properties, improved postformability and a significant reduction in the release of volatile organics during formation.