Abstract: Resin peptides useful in the preparation of salmon calcitonin are disclosed along with processes for preparing the same. The invention also embraces peptides from which the resin moiety has been cleaved and which are useful in the synthesis of salmon calcitonin together with processes for preparing the cleaved peptides. In general, the processes involve the solid phase synthesis procedures.

Abstract: Tetrahydroisoquinoline compounds represented by the formula: ##SPC1##In whichX is a hydroxy group,Y is a hydroxy group orY taken with X is --O--CH.sub.2 --O--,Z is hydrogen or a hydroxy group,R.sub.1 is hydrogen or an alkyl group of one to four carbon atoms,R.sub.2 is hydrogen, an alkyl group of one to four carbon atoms or phenyl, pyrrolidinomethyl, piperidinomethyl, or morpholinomethyl,R.sub.3 and R.sub.4 each is an alkyl group of one to four carbon atoms or R.sub.3 taken with R.sub.4 and N is pyrrolidinyl, piperidino, morpholino, or 2-(1,2,3,4-tetrahydroisoquinolyl), andn is one or zero,Which compounds are effective as vasodilators, processes for the preparation of these compounds, and intermediate compounds useful in the preparation of such compounds.

Abstract: Compounds having the structure: ##SPC1##In which R.sub.1 and R.sub.2 are alkoxy groups of one to four carbon atoms, R.sub.3 and R.sub.4 each is hydrogen or an alkoxy group of one to four carbon atoms, and R.sub.5 and R.sub.6 each is an alkyl group of one to four carbon atoms or an arylalkyl group such as benzyl or R.sub.5 taken with R.sub.6 and N are pyrrolidinyl, piperidino, or morpholino groups and the pharmaceutically acceptable salts thereof and processes for preparing these compounds. These compounds are useful as vasodilators.