Patents by Inventor Jay M. Matthews

Jay M. Matthews has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Sulfamides as TRPM8 modulators
    Patent number: 8748478
    Abstract: Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein Y, R1, R2, R3, R4, RA, and RB are defined herein.
    Type: Grant
    Filed: March 28, 2013
    Date of Patent: June 10, 2014
    Assignee: Janssen Pharmaceutica, NV
    Inventor: Jay M Matthews
  • COLD MENTHOL RECEPTOR-1 ANTAGONISTS
    Publication number: 20140100194
    Abstract: The invention is directed to TRPM8 antagonists of Formula (I). More specifically, the present invention relates to certain novel compounds, methods for preparing compounds, compositions, intermediates and derivatives thereof and methods for treating TRPM8-mediated disorders. Pharmaceutical and veterinary compositions and methods of treating pain and various other disease states or conditions using compounds of the invention are also described.
    Type: Application
    Filed: December 5, 2013
    Publication date: April 10, 2014
    Applicant: Janssen Pharmaceutica, NV
    Inventors: Raymond W Colburn, Scott L. Dax, Christopher M. Flores, Jay M. Matthews
  • IMIDAZO[1,2-a]PYRIDINE SULFONAMIDES AS TRPM8 MODULATORS
    Publication number: 20140088098
    Abstract: Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein Y, R1, R2, and are defined herein.
    Type: Application
    Filed: November 25, 2013
    Publication date: March 27, 2014
    Applicant: Janssen Pharmaceutica, NV
    Inventors: Mark J. Macielag, Mingde Xia, James J. McNally, Jay M. Matthews
  • Imidazo[1,2-?]pyridine sulfonamides as TRPM8 modulators
    Patent number: 8618150
    Abstract: Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein Y, R1, R2, and are defined herein.
    Type: Grant
    Filed: December 9, 2011
    Date of Patent: December 31, 2013
    Assignee: Janssen Pharmaceutica, NV
    Inventors: Mark J. Macielag, Mingde Xia, James J. McNally, Jay M. Matthews
  • Cold menthol receptor-1 antagonists
    Patent number: 8558011
    Abstract: The invention is directed to TRPM8 antagonists of Formula (I). More specifically, the present invention relates to certain novel compounds, methods for preparing compounds, compositions, intermediates and derivatives thereof and methods for treating TRPM8-mediated disorders. Pharmaceutical and veterinary compositions and methods of treating pain and various other disease states or conditions using compounds of the invention are also described.
    Type: Grant
    Filed: August 31, 2010
    Date of Patent: October 15, 2013
    Assignee: Janssen Pharmaceutica, NV
    Inventors: Raymond W Colburn, Scott L Dax, Christopher Flores, Jay M Matthews
  • SULFAMIDES AS TRPM8 MODULATORS
    Publication number: 20130237547
    Abstract: Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein Y, R1, R2, R3, R4, RA, and RB are defined herein.
    Type: Application
    Filed: March 28, 2013
    Publication date: September 12, 2013
    Applicant: Janssen Pharmaceutica, NV
    Inventor: Jay M. Matthews
  • Sulfamides as TRPM8 modulators
    Patent number: 8436041
    Abstract: Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein Y, R1, R2, R3, R4, RA, and RB are defined herein.
    Type: Grant
    Filed: December 15, 2009
    Date of Patent: May 7, 2013
    Assignee: Janssen Pharmaceutica, NV
    Inventor: Jay M. Matthews
  • Cold menthol receptor antagonists
    Patent number: 8324217
    Abstract: Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein A, B, L, Q, R1, R2, and R3 are defined herein.
    Type: Grant
    Filed: February 6, 2012
    Date of Patent: December 4, 2012
    Assignee: Janssen Pharmaceutica NV
    Inventors: Raymond W. Colburn, Scott L. Dax, Christopher M. Flores, Donald W. Ludovici, Jay M. Matthews, Mingde Xia, Xiaoqing Xu, Mark A. Youngman, Bin Zhu
  • SULFONAMIDES AS TRPM8 MODULATORS
    Publication number: 20120190674
    Abstract: Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein A, B, G, Y, R1, R2, R3, and R4 are defined herein.
    Type: Application
    Filed: February 28, 2012
    Publication date: July 26, 2012
    Inventors: Shawn T. Branum, Raymond W. Colburn, Scott L. Dax, Christopher M. Flores, Michele C. Jetter, Yi Liu, Donald Ludovici, Mark J. Macielag, Jay M. Matthews, James J. McNally, Laura M. Reaney, Ronald K. Russell, Ning Qin, Christopher Teleha, Kenneth M. Wells, Scott C. Youells, Mark A. Youngman
  • Radiolabelled TRP M8 receptor ligands
    Patent number: 8216547
    Abstract: The present invention is directed to radiolabelled ligands, useful for the labeling and imaging of TRP M8 (transient receptor potential M8 channel) functionality. The present invention is further directed to pharmaceutical compositions comprising the radiolabelled ligands and methods for the preparation of the radiolabelled ligands.
    Type: Grant
    Filed: July 9, 2009
    Date of Patent: July 10, 2012
    Assignee: Janssen Pharmaceutica NV
    Inventors: Paul D. Acton, Dennis J. Hlasta, Jay M. Matthews, James J. McNally
  • IMIDAZO[1,2-a]PYRIDINE SULFONAMIDES AS TRPM8 MODULATORS
    Publication number: 20120149699
    Abstract: Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein Y, R1, R2, and are defined herein.
    Type: Application
    Filed: December 9, 2011
    Publication date: June 14, 2012
    Inventors: Mark J. Macielag, Mingde Xia, James J. McNally, Jay M. Matthews
  • COLD MENTHOL RECEPTOR ANTAGONISTS
    Publication number: 20120136006
    Abstract: Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein A, B, L, Q, R1, R2, and R3 are defined herein.
    Type: Application
    Filed: February 6, 2012
    Publication date: May 31, 2012
    Inventors: Raymond W. Colburn, Scott L. Dax, Christopher M. Flores, Donald W. Ludovici, Jay M. Matthews, Mingde Xia, Xiaoqing Xu, Mark A. Youngman, Bin Zhu
  • Sulfonamides as TRPM8 modulators
    Patent number: 8153682
    Abstract: Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein A, B, G, Y, R1, R2, R3, and R4 are defined herein.
    Type: Grant
    Filed: July 18, 2008
    Date of Patent: April 10, 2012
    Assignee: Janssen Pharmaceutica, NV
    Inventors: Shawn T. Branum, Raymond W. Colburn, Scott L. Dax, Christopher M. Flores, Michele C. Jetter, Yi Liu, Donald Ludovici, Mark J. Macielag, Jay M. Matthews, James J. McNally, Laura M. Reaney, Ronald K. Russell, Ning Qin, Christopher Teleha, Kenneth M. Wells, Scott C. Youells, Mark A. Youngman
  • Cold menthol receptor antagonists
    Patent number: 8143259
    Abstract: Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein A, B, L, Q, R1, R2, and R3 are defined herein.
    Type: Grant
    Filed: August 11, 2009
    Date of Patent: March 27, 2012
    Assignee: Janssen Pharmaceutica, NV
    Inventors: Raymond W. Colburn, Scott L. Dax, Christopher M. Flores, Donald W. Ludovici, Jay M. Matthews, Mingde Xia, Xiaoqing Xu, Mark A. Youngman, Bin Zhu
  • SULFAMIDES AS TRPM8 MODULATORS
    Publication number: 20100160337
    Abstract: Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein Y, R1, R2, R3, R4, RA, and RB are defined herein.
    Type: Application
    Filed: December 15, 2009
    Publication date: June 24, 2010
    Inventor: Jay M. Matthews
  • Cold Menthol Receptor Antagonists
    Publication number: 20100048589
    Abstract: Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein A, B, L, Q, R1, R2, and R3 are defined herein.
    Type: Application
    Filed: August 11, 2009
    Publication date: February 25, 2010
    Inventors: Raymond W. Colburn, Scott L. Dax, Christopher M. Flores, Donald W. Ludovici, Jay M. Matthews, Mingde Xia, Xiaoqing Xu, Mark A. Youngman, Bin Zhu
  • RADIOLABELLED TRP M8 RECEPTOR LIGANDS
    Publication number: 20100015053
    Abstract: The present invention is directed to radiolabelled ligands, useful for the labeling and imaging of TRP M8 (transient receptor potential M8 channel) functionality. The present invention is further directed to pharmaceutical compositions comprising the radiolabelled ligands and methods for the preparation of the radiolabelled ligands.
    Type: Application
    Filed: July 9, 2009
    Publication date: January 21, 2010
    Inventors: Paul D. Acton, Dennis J. Hlasta, Jay M. Matthews, James J. McNally
  • SULFONAMIDES AS TRPM8 MODULATORS
    Publication number: 20090264474
    Abstract: Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein A, B, G, Y, R1, R2, R3, and R4 are defined herein.
    Type: Application
    Filed: July 18, 2008
    Publication date: October 22, 2009
    Inventors: Shawn T. Branum, Raymond W. Colburn, Scott L. Dax, Christopher M. Flores, Michele C. Jetter, Yi Liu, Donald Ludovici, Mark J. Macielag, Jay M. Matthews, James J. McNally, Laura M. Reaney, Ronald K. Russell, Ning Qin, Christopher Teleha, Kenneth M. Wells, Scott C. Youells, Mark A. Youngman
  • Methods of using substituted tetralins and indanes
    Patent number: 7351857
    Abstract: The invention features tetralin and indane compounds, compositions containing them, and methods of using them as PPAR alpha modulators to treat or inhibit the progression of, for example, diabetes.
    Type: Grant
    Filed: June 3, 2005
    Date of Patent: April 1, 2008
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Xiaoli Chen, Keith T. Demarest, Jung Lee, Jay M. Matthews, Philip Rybczynski
  • Tricyclic benzodiazepines as vasopressin receptor antagonists
    Patent number: 7317005
    Abstract: The invention is directed to tricyclic benzodiazepines useful as vasopressin receptor antagonists for treating conditions involving increased vascular resistance and cardiac insufficiency. Pharmaceutical compositions comprising tricyclic benzodiazepines of the present invention and methods of treating conditions such as hypertension, congestive heart failure, cardiac insufficiency, coronary vasospasm, cardiac ischemia, liver cirrhosis, renal vasospasm, renal failure, cerebral edema and ischemia, stroke, thrombosis, or water retention are also disclosed.
    Type: Grant
    Filed: February 10, 2004
    Date of Patent: January 8, 2008
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: William J. Hoekstra, Alexey B. Dyatkin, Bruce E. Maryanoff, Jay M. Matthews