Abstract: The present disclosure provides a nucleic acid amplification test molecular diagnostic device. In this respect, a system can include a reusable base component having a heater and a disposable component including a reaction chamber and a sample receiving portion that is fluidly coupled to the reaction chamber. The base component can heat a sample fluid within the reaction chamber. Light can be directed to the reaction chamber, and light can be transmitted light from the reaction chamber to an optical detector. Data may be transmitted to an external device. Certain devices may be used for at home or point-of-care testing, and some devices may be used for laboratory testing.