Abstract: A multichannel, multipurpose sample collection and drug delivery system for laboratory animals includes several sampling and/or infusion devices mounted on a powered turntable above the cage but out of the animal's sight. Probes are constructed using a unique four-channel design: this permits (a) the periodic infusion of drugs without the possibility of artifacts due to pressure shocks and (b) the addition of preservatives to the sample at the site of its collection. A simplified sample collection device stores samples in a coil of PTFE tubing, and a constant-pressure perfusion system serves microdialysis probes.

Abstract: A multichannel, multipurpose sample collection and drug delivery system for freely-moving laboratory animals includes several sampling and/or infusion devices mounted on a powered turntable above the cage but out of the animal's sight. Rotation of the tether as the animal moves is detected by magnetic switches, which cause the turntable to turn in the direction taken by the animal. Fluid or electrical swivels are entirely eliminated; the animal experiences almost zero torque on the tether. As the swivel normally limits the number of fluid or electrical connections in traditional systems, eliminating the swivel removes this constraint. Multiple probes can now be placed in alert, freely moving animals to sample several brain regions simultaneously.