Patents by Inventor Jay Milton Short

Jay Milton Short has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SIMULTANEOUS, INTEGRATED SELECTION AND EVOLUTION OF ANTIBODY/PROTEIN PERFORMANCE AND EXPRESSION IN PRODUCTION HOSTS
    Publication number: 20210207129
    Abstract: The present disclosure provides methods of integrating therapeutic protein and antibody generation and/or selection, evolution and expression in a eukaryotic host for manufacturing in a single system. Therapeutic proteins, including antibodies, are generated, optimized and manufactured in the same eukaryotic host system. The disclosed system of Comprehensive Integrated Antibody Optimization (CIAO!™) allows for simultaneous evolution of protein performance and expression optimization.
    Type: Application
    Filed: January 27, 2021
    Publication date: July 8, 2021
    Applicant: BioAtla, Inc.
    Inventor: Jay Milton Short
  • Simultaneous, integrated selection and evolution of antibody/protein performance and expression in production hosts
    Patent number: 10920216
    Abstract: The present disclosure provides methods of integrating therapeutic protein and antibody generation and/or selection, evolution and expression in a eukaryotic host for manufacturing in a single system. Therapeutic proteins, including antibodies, are generated, optimized and manufactured in the same eukaryotic host system. The disclosed system of Comprehensive Integrated Antibody Optimization (CIAO!™) allows for simultaneous evolution of protein performance and expression optimization.
    Type: Grant
    Filed: August 31, 2018
    Date of Patent: February 16, 2021
    Assignee: BioAtla, Inc.
    Inventor: Jay Milton Short
  • SIMULTANEOUS, INTEGRATED SELECTION AND EVOLUTION OF ANTIBODY/PROTEIN PERFORMANCE AND EXPRESSION IN PRODUCTION HOSTS
    Publication number: 20180371452
    Abstract: The present disclosure provides methods of integrating therapeutic protein and antibody generation and/or selection, evolution and expression in a eukaryotic host for manufacturing in a single system. Therapeutic proteins, including antibodies, are generated, optimized and manufactured in the same eukaryotic host system. The disclosed system of Comprehensive Integrated Antibody Optimization (CIAO!™) allows for simultaneous evolution of protein performance and expression optimization.
    Type: Application
    Filed: August 31, 2018
    Publication date: December 27, 2018
    Applicant: BioAtla, LLC
    Inventor: Jay Milton Short
  • Simultaneous, integrated selection and evolution of antibody/protein performance and expression in production hosts
    Patent number: 10106788
    Abstract: The present disclosure provides methods of integrating therapeutic protein and antibody generation and/or selection, evolution and expression in a eukaryotic host for manufacturing in a single system. Therapeutic proteins, including antibodies, are generated, optimized and manufactured in the same eukaryotic host system. The disclosed system of Comprehensive Integrated Antibody Optimization (CIAO!™) allows for simultaneous evolution of protein performance and expression optimization.
    Type: Grant
    Filed: November 17, 2011
    Date of Patent: October 23, 2018
    Assignee: BIOATLA, LLC
    Inventor: Jay Milton Short
  • Simultaneous, integrated selection and evolution of antibody/protein performance and expression in production hosts
    Patent number: 10047357
    Abstract: The present disclosure provides methods of integrating therapeutic protein and antibody generation and/or selection, evolution and expression in a eukaryotic host for manufacturing in a single system. Therapeutic proteins, including antibodies, are generated, optimized and manufactured in the same eukaryotic host system. The disclosed system of Comprehensive Integrated Antibody Optimization (CIAO!™) allows for simultaneous evolution of protein performance and expression optimization.
    Type: Grant
    Filed: September 9, 2014
    Date of Patent: August 14, 2018
    Assignee: BIOATLA, LLC
    Inventor: Jay Milton Short
  • SIMULTANEOUS, INTEGRATED SELECTION AND EVOLUTION OF ANTIBODY/PROTEIN PERFORMANCE AND EXPRESSION IN PRODUCTION HOSTS
    Publication number: 20150024944
    Abstract: The present disclosure provides methods of integrating therapeutic protein and antibody generation and/or selection, evolution and expression in a eukaryotic host for manufacturing in a single system. Therapeutic proteins, including antibodies, are generated, optimized and manufactured in the same eukaryotic host system. The disclosed system of Comprehensive Integrated Antibody Optimization (CIAO!™) allows for simultaneous evolution of protein performance and expression optimization.
    Type: Application
    Filed: September 9, 2014
    Publication date: January 22, 2015
    Inventor: Jay Milton Short
  • Simultaneous, integrated selection and evolution of antibody/protein performance and expression in production hosts
    Patent number: 8859467
    Abstract: The present disclosure provides methods of integrating therapeutic protein and antibody generation and/or selection, evolution and expression in a eukaryotic host for manufacturing in a single system. Therapeutic proteins, including antibodies, are generated, optimized and manufactured in the same eukaryotic host system. The disclosed system of Comprehensive Integrated Antibody Optimization (CIAO!™) allows for simultaneous evolution of protein performance and expression optimization.
    Type: Grant
    Filed: July 16, 2010
    Date of Patent: October 14, 2014
    Assignee: Bioatla, LLC
    Inventor: Jay Milton Short
  • SIMULTANEOUS, INTEGRATED SELECTION AND EVOLUTION OF ANTIBODY/PROTEIN PERFORMANCE AND EXPRESSION IN PRODUCTION HOSTS
    Publication number: 20120245036
    Abstract: The present disclosure provides methods of integrating therapeutic protein and antibody generation and/or selection, evolution and expression in a eukaryotic host for manufacturing in a single system. Therapeutic proteins, including antibodies, are generated, optimized and manufactured in the same eukaryotic host system. The disclosed system of Comprehensive Integrated Antibody Optimization (CIAO!™) allows for simultaneous evolution of protein performance and expression optimization.
    Type: Application
    Filed: November 17, 2011
    Publication date: September 27, 2012
    Applicant: BIOATLA, LLC
    Inventor: Jay Milton Short
  • SIMULTANEOUS, INTEGRATED SELECTION AND EVOLUTION OF ANTIBODY/PROTEIN PERFORMANCE AND EXPRESSION IN PRODUCTION HOSTS
    Publication number: 20120165201
    Abstract: The present disclosure provides methods of integrating therapeutic protein and antibody generation and/or selection, evolution and expression in a eukaryotic host for manufacturing in a single system. Therapeutic proteins, including antibodies, are generated, optimized and manufactured in the same eukaryotic host system. The disclosed system of Comprehensive Integrated Antibody Optimization (CIAO!™) allows for simultaneous evolution of protein performance and expression optimization.
    Type: Application
    Filed: July 16, 2010
    Publication date: June 28, 2012
    Inventor: Jay Milton Short
  • Temperature sensitive mutants of matrix metalloproteases and uses thereof
    Publication number: 20100284995
    Abstract: Provided are modified matrix metalloprotease (MMP) enzymes that exhibit temperature-dependent activity and uses thereof. The MMPs can be used, for example, to treat ECM-mediated diseases or disorders characterized by increased deposition or accumulation of one or more ECM components.
    Type: Application
    Filed: March 5, 2010
    Publication date: November 11, 2010
    Inventors: Louis Bookbinder, Gregory I. Frost, Gilbert Keller, Gerhard Johann Frey, Hwai Wen Chang, Jay Milton Short