Patents by Inventor Jay N. Cohn
Jay N. Cohn has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8715194Abstract: Screening apparently healthy individuals using sensitive techniques for identifying early vascular and cardiac disease provides the opportunity for effective intervention to prevent or delay the occurrence of cardiovascular events which represent the most common cause of morbidity and mortality in our society. Preliminary studies have revealed an incidence of over 50% of early disease in need of therapy. The apparent ineffectiveness of the health care system to uncover this early disease emphasizes the need for a more aggressive community approach to screen for early disease and to initiate therapy that should reduce health care costs and improve quality and duration of life.Type: GrantFiled: October 10, 2006Date of Patent: May 6, 2014Assignee: Regents of the University of MinnesotaInventor: Jay N. Cohn
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Patent number: 8636660Abstract: A system and method for dynamic multi-stage test administration for detection of cardiovascular disease may include performing a first set of tests in a first stage of testing on a patient. Physiological results for each of the tests in the first stage may then be received. Then, based on the physiological results, dynamically determining a set of tests to perform on the subject in a second stage of testing. Additionally, the dynamically determined set of tests in the second stage of testing may be performed on the subject.Type: GrantFiled: October 9, 2012Date of Patent: January 28, 2014Assignee: Regents of the University of MinnesotaInventor: Jay N. Cohn
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Publication number: 20080226752Abstract: The present invention provides methods of treating and preventing mortality associated with heart failure in an African American patient with hypertension and improving oxygen consumption, quality of life and exercise tolerance by administering a therapeutically effective amount of at least one hydralazine compound and at least one of isosorbide dinitrate and isosorbide mononitrate, and, optionally, one or more compounds, such as, for example, a digitalis, a diuretic compound, or a compound used to treat cardiovascular diseases. In the present invention, the hydralazine compound is preferably hydralazine or a pharmaceutically acceptable salt thereof. Preferred methods of the invention comprise administering hydralazine or a pharmaceutically acceptable salt thereof and isosorbide dinitrate.Type: ApplicationFiled: March 21, 2008Publication date: September 18, 2008Applicant: NITROMED, INC.Inventors: Jay N. COHN, Peter CARSON
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Publication number: 20040204371Abstract: The present invention provides methods of treating and preventing mortality associated with heart failure in an African American patient with hypertension and improving oxygen consumption, quality of life and exercise tolerance by administering a therapeutically effective amount of at least one hydralazine compound and at least one of isosorbide dinitrate and isosorbide mononitrate, and, optionally, one or more compounds, such as, for example, a digitalis, a diuretic compound, or a compound used to treat cardiovascular diseases. In the present invention, the hydralazine compound is preferably hydralazine or a pharmaceutically acceptable salt thereof. Preferred methods of the invention comprise administering hydralazine or a pharmaceutically acceptable salt thereof and isosorbide dinitrate.Type: ApplicationFiled: April 15, 2004Publication date: October 14, 2004Applicant: NitroMed, Inc.Inventors: Jay N. Cohn, Peter Carson
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Patent number: 6784177Abstract: The present invention provides methods of treating and preventing mortality associated with heart failure in an African American patient with hypertension, and improving oxygen consumption, quality of life and exercise tolerance by administering a therapeutically effective amount of at least one hydralazine compound and at least one of isosorbide dinitrate and isosorbide mononitrate, and, optionally, one or more compounds, such as, for example, a digitalis, a diuretic compound, or a compound used to treat cardiovascular diseases. In the present invention, the hydralazine compound is preferably hydralazine or a pharmaceutically acceptable salt thereof. Preferred methods of the invention comprise administering hydralazine or a pharmaceutically acceptable salt thereof and isosorbide dinitrate.Type: GrantFiled: August 2, 2002Date of Patent: August 31, 2004Assignee: Nitro Med, Inc.Inventors: Jay N. Cohn, Peter Carson
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Patent number: 6689069Abstract: Methods and apparatus for processing an arterial blood pressure waveform to extract clinically useful information on the state of the cardiovascular system are disclosed herein. In order to obtain the parameters of the modified Windkessel model, the diastolic portion of a subject's blood pressure waveform is scanned over a plurality of ranges and the range that produces the best fit of data and lowest error estimates are selected. In addition, multiple empirically determined starting values of the ‘A’ parameters are used to find the best fit of the model data to the actual arterial blood pressure waveform data.Type: GrantFiled: May 28, 2002Date of Patent: February 10, 2004Assignee: Hypertension Diagnostics, Inc.Inventors: Christopher W. Bratteli, Jay N. Cohn, Stanley M. Finkelstein, Dennis J. Morgan
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Publication number: 20040023967Abstract: The present invention provides methods of treating and preventing mortality associated with heart failure in an African American patient with hypertension, and improving oxygen consumption, quality of life and exercise tolerance by administering a therapeutically effective amount of at least one hydralazine compound and at least one of isosorbide dinitrate and isosorbide mononitrate, and, optionally, one or more compounds, such as, for example, a digitalis, a diuretic compound, or a compound used to treat cardiovascular diseases. In the present invention, the hydralazine compound is preferably hydralazine or a pharmaceutically acceptable salt thereof. Preferred methods of the invention comprise administering hydralazine or a pharmaceutically acceptable salt thereof and isosorbide dinitrate.Type: ApplicationFiled: August 2, 2002Publication date: February 5, 2004Inventors: Jay N. Cohn, Peter Carson
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Patent number: 6623434Abstract: A vascular impedance measurement instrument includes a transducer to obtain a digitized arterial blood pressure waveform. The digitized data is used to determine cardiac output, and to subsequently obtain measurements of impedance parameters using the modified Windkessel model of the arterial system. The instrument is used as an aid in diagnosing, treating and monitoring patients with cardiovascular disease.Type: GrantFiled: September 17, 2001Date of Patent: September 23, 2003Assignee: Hypertension Diagnostics, Inc.Inventors: Charles F. Chesney, Stanley M. Finkelstein, Jay N. Cohn
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Publication number: 20030023173Abstract: Methods and apparatus for processing an arterial blood pressure waveform to extract clinically useful information on the state of the cardiovascular system are disclosed herein. In order to obtain the parameters of the modified Windkessel model, the diastolic portion of a subject's blood pressure waveform is scanned over a plurality of ranges and the range that produces the best fit of data and lowest error estimates are selected. In addition, multiple empirically determined starting values of the ‘A’ parameters are used to find the best fit of the model data to the actual arterial blood pressure waveform data.Type: ApplicationFiled: May 28, 2002Publication date: January 30, 2003Applicant: Hypertension Diagnostics, Inc.Inventors: Christopher W. Bratteli, Jay N. Cohn, Stanley M. Finkelstein, Dennis J. Morgan
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Patent number: 6465463Abstract: The present invention provides methods or treating and preventing mortality associated with heart failure in an African American patient with hypertension and improving oxygen consumption, quality of life and exercise tolerance by administering a therapeutically effective amount of at least one hydralazine compound and at least one of isosorbide dinitrate and isosorbide mononitrate, and, optionally, one or more compounds, such as, for example, a digitalis, a diuretic compound, or a compound used to treat cardiovascular diseases. In the present invention, the hydralazine compound is preferably hydralazine or a pharmaceutically acceptable salt thereof. Preferred methods of the invention comprise administering hydralazine or a pharmaceutically acceptable salt thereof and isosorbide dinitrate.Type: GrantFiled: September 8, 2000Date of Patent: October 15, 2002Assignee: NitroMed, Inc.Inventors: Jay N. Cohn, Peter Carson
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Patent number: 6394958Abstract: Methods and apparatus for processing an arterial blood pressure waveform to extract clinically useful information on the state of the cardiovascular system are disclosed herein. In order to obtain the parameters of the modified Windkessel model, the diastolic portion of a subject's blood pressure waveform is scanned over a plurality of ranges and the range that produces the best fit of data and lowest error estimates are selected. In addition, multiple empirically determined starting values of the ‘A’ parameters are used to find the best fit of the model data to the actual arterial blood pressure waveform data.Type: GrantFiled: November 5, 1999Date of Patent: May 28, 2002Assignee: Hypertension Diagnostics, Inc.Inventors: Christopher W. Bratteli, Jay N. Cohn, Stanley M. Finkelstein, Dennis J. Morgan
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Publication number: 20020028998Abstract: A vascular impedance measurement instrument includes a transducer to obtain a digitized arterial blood pressure waveform. The digitized data is used to determine cardiac output, and to subsequently obtain measurements of impedance parameters using the modified Windkessel model of the arterial system. The instrument is used as an aid in diagnosing, treating and monitoring patients with cardiovascular disease.Type: ApplicationFiled: September 17, 2001Publication date: March 7, 2002Applicant: Hypertension Diagnostics, Inc.Inventors: Charles F. Chesney, Stanley M. Finkelstein, Jay N. Cohn
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Patent number: 6290651Abstract: A vascular impedance measurement instrument includes a transducer to obtain a digitized arterial blood pressure waveform. The digitized data is used to determine cardiac output, and to subsequently obtain measurements of impedance parameters using the modified Windkessel model of the arterial system. The instrument is used as an aid in diagnosing, treating and monitoring patients with cardiovascular disease.Type: GrantFiled: April 10, 2000Date of Patent: September 18, 2001Assignee: Hypertension Diagnostics, Inc.Inventors: Charles F. Chesney, Stanley M. Finkelstein, Jay N. Cohn
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Patent number: 6048318Abstract: A vascular impedance measurement instrument includes a transducer to obtain a digitized arterial blood pressure waveform. The digitized data is used to determine cardiac output, and to subsequently obtain measurements of impedance parameters using the modified Windkessel model of the arterial system. The instrument is used as an aid in diagnosing, treating and monitoring patients with cardiovascular disease.Type: GrantFiled: January 26, 1999Date of Patent: April 11, 2000Assignee: Hypertension Diagnostic, Inc.Inventors: Charles F. Chesney, Stanley M. Finkelstein, Jay N. Cohn
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Patent number: 6017313Abstract: Methods and apparatus for processing an arterial blood pressure waveform to extract clinically useful information on the state of the cardiovascular system are disclosed herein. In order to obtain the parameters of the modified Windkessel model, the diastolic portion of a subject's blood pressure waveform is scanned over a plurality of ranges and the range that produces the best fit of data and lowest error estimates are selected. In addition, multiple empirically determined starting values of the `A` parameters are used to find the best fit of the model data to the actual arterial blood pressure waveform data.Type: GrantFiled: March 20, 1998Date of Patent: January 25, 2000Assignee: Hypertension Diagnostics, Inc.Inventors: Christopher W. Bratteli, Jay N. Cohn, Stanley M. Finkelstein, Dennis J. Morgan
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Patent number: 5876347Abstract: A vascular impedance measurement instrument includes a transducer to obtain a digitized arterial blood pressure waveform. The digitized data is used to determine cardiac output, and to subsequently obtain measurements of impedance parameters using the modified Windkessel model of the arterial system. The instrument is used as an aid in diagnosing, treating and monitoring patients with cardiovascular disease.Type: GrantFiled: September 23, 1997Date of Patent: March 2, 1999Assignee: Regents of the University of MinnesotaInventors: Charles F. Chesney, Stanley M. Finkelstein, Jay N. Cohn
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Patent number: 5316004Abstract: A vascular impedance measurement instrument includes a transducer to obtain a digitized arterial blood pressure waveform. The digitized data is used to determine cardiac output, and to subsequently obtain measurements of impedance parameters using the modified Windkessel model of the arterial system. The instrument is used as an aid in diagnosing, treating and monitoring patients with cardiovascular disease.Type: GrantFiled: March 26, 1993Date of Patent: May 31, 1994Assignee: Regents of the University of MinnesotaInventors: Charles F. Chesney, Stanley M. Finkelstein, Jay N. Cohn
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Patent number: 5241966Abstract: Apparatus for Measuring Stroke Volume/Cardiac Output includes a transducer for measuring arterial blood pressure waveform, a digitizer for digitizing the analog signal generated by the transducer and a digital signal processor for determining ejection time and heart rate. Processor circuitry determines cardiac output using the ejection time, heart rate, the body surface area and age of the patient, with the cardiac output measure being displayed by the meter.Type: GrantFiled: November 17, 1992Date of Patent: September 7, 1993Assignee: Hypertension Diagnostics, Inc.Inventors: Stanley M. Finkelstein, Jay N. Cohn
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Patent number: 5211177Abstract: A vascular impedance measurement instrument includes a transducer to obtain a digitized arterial blood pressure waveform. The digitized data is used to determine cardiac output, and to subsequently obtain measurements of impedance parameters using the modified Windkessel model of the arterial system. The instrument is used as an aid in diagnosing, treating and monitoring patients with cardiovascular disease.Type: GrantFiled: December 28, 1990Date of Patent: May 18, 1993Assignee: Regents of the University of MinnesotaInventors: Charles F. Chesney, Stanley M. Finkelstein, Jay N. Cohn
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Patent number: 5054493Abstract: A method for diagnosing, monitoring and treating hypertension uses the parameter C.sub.2 of the modified Windkessel model as an indication of the hypertensive disease condition. Apparatus for determining the parameter C.sub.2 (i.e. distal vascular compliance) of the modified Windkessel model includes means for obtaining a pressure pulse contour and a cardiac output value and for determining the model parameters.Type: GrantFiled: February 5, 1991Date of Patent: October 8, 1991Assignee: Regents of the University of MinnesotaInventors: Jay N. Cohn, Stanley M. Finkelstein