Abstract: Compounds that inhibit HIF-2?, and compositions containing the compound(s) and methods for synthesizing the compounds, are described herein. Also described are the use of such compounds and compositions for the treatment of a diverse array of diseases, disorders, and conditions, including cancer- and immune-related disorders that are mediated, at least in part, by HIF-2?.

Abstract: A gate valve can include a valve body, a bore positioned within the valve body, where the bore traverses a width of the valve body and comprises an inlet and an outlet, and a gate slidably disposed within the bore. The gate valve can further include a seat disposed around the bore and adjacent to the gate and the valve body, where an inner surface of the second piece is adjacent to the gate, where an outer surface of the first piece is adjacent to the valve body, where the first piece and the second piece are adjacent to each other, where a spring system includes a cavity disposed between the first piece and the second piece and a spring section, where the spring section protrudes outward relative to the second piece and moves inward to reduce a volume of the cavity when the gate contacts the spring section.

Abstract: Compounds that are inhibitors of at least one of ARG1 and ARG2, and compositions containing the compounds and methods for synthesizing the compounds, are described herein. The use of such compounds and compositions for the treatment of a diverse array of diseases, disorders, and conditions, including cancer- and immune-related disorders that are mediated, at least in part, by ARG1 and ARG2 are also described herein.

Abstract: A tubing hanger retention system for a wellhead assembly can include a retention ring that is configured to fit over a top portion of a tubing hanger of the wellhead assembly, where the retention ring comprises a plurality of retention ring channels. The tubing hanger retention system can also include multiple retention pin receiving features configured to be disposed, at least in part, within multiple tubing spool channels of a tubing spool. The tubing hanger retention system can further include multiple retention pins configured to be received by the retention pin receiving features, where each retention pin includes an engagement feature configured to be received by a retention pin receiving feature to place the retention pin in a captured state, where the engagement feature of each retention pin is further configured to enter into an engaged state with a retention ring channel when the retention pin is moved inward.

Abstract: A wellhead housing of a wellhead assembly can include a body having a top end, a bottom end, and a cavity that traverses its length between the top end and the bottom end. The wellhead housing can also include a main channel that traverses the body from the cavity at a distal end of the main channel to an outer perimeter of the body at a proximal end of the main channel, where the proximal end of the main channel is located closer to the top end of the body compared to the distal end of the main channel, and where the distal end of the main channel is located closer to the bottom end of the body compared to the proximal end of the main channel.

Abstract: A wellhead bracing system for a subsea well includes a base plate assembly and a wellhead brace assembly. The base plate assembly comprises a top surface, a bottom surface, a base plate aperture, and a plurality of anchor holes. The wellhead brace assembly comprises a vertical plate assembly having a cylindrical shape, a horizontal plate assembly to which the vertical plate assembly is attached, and a vertical support assembly attached to an outer surface of the vertical plate assembly and attached to the top surface of the horizontal plate assembly. Horizontal plate holes of the horizontal plate assembly are configured to attach to studs on the top surface of the base plate to secure the wellhead brace assembly to the base plate assembly. The wellhead bracing system slides onto a wellhead of the subsea well and braces an exterior of the wellhead.

Abstract: Compounds of Formula I that inhibit AXL, and compositions containing the compound(s) and methods for synthesizing the compounds, are described herein. Also described are the use of such compounds and compositions for the treatment of a diverse array of diseases, disorders, and conditions, including cancer, that are mediated, at least in part, by AXL.

Abstract: Compounds of Formula I that inhibit AXL, and compositions containing the compound(s) and methods for synthesizing the compounds, are described herein. Also described are the use of such compounds and compositions for the treatment of a diverse array of diseases, disorders, and conditions, including cancer, that are mediated, at least in part, by AXL.

Abstract: Compounds that modulate the conversion of AMP to adenosine by 5?-nucleotidase, ecto, and compositions containing the compounds and methods for synthesizing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by 5?-nucleotidase, ecto is also provided.

Abstract: A tubing spool of a wellhead assembly can include a body having a body cavity, a first channel, and a second channel disposed therein, where the body cavity is configured to receive a tubing hanger used to couple to and suspend a tubing string, where the first channel is configured to be in communication with a tubing string cavity within the tubing string, where the second channel is configured to be in communication with an annulus located between the tubing string and a production casing, and where the first channel and the second channel are each configured to facilitate flow of at least one of a plurality of fluids in either direction independently of each other. The tubing spool can also include a first back pressure valve disposed within the first channel and a second back pressure valve disposed within the second channel.

Abstract: Compounds that modulate the conversion of AMP to adenosine by 5?-nucleotidase, ecto, and compositions containing the compounds and methods for synthesizing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by 5?-nucleotidase, ecto is also provided.

Abstract: A gate valve can include a valve body and a bore positioned within the valve body, where the bore traverses a width of the valve body and comprises an inlet and an outlet. The gate valve can also include a gate slidably disposed within the bore. The gate valve can further include a seat disposed around the bore and adjacent to the gate and the valve body, where the seat includes a seat body having a spring system and an inner surface, where the inner surface is adjacent to the gate, where the spring system includes a cavity disposed in the seat body and a spring section positioned between the cavity and the inner surface, where the spring section protrudes outward relative to the inner surface, where the spring section is configured to move inward and reduce a volume of the cavity when the gate contacts the spring section.

Abstract: Compounds that inhibit HIF-2?, and compositions containing the compound(s) and methods for synthesizing the compounds, are described herein. Also described are the use of such compounds and compositions for the treatment of a diverse array of diseases, disorders, and conditions, including cancer- and immune-related disorders that are mediated, at least in part, by HIF-2?.

Abstract: Compounds that modulate the conversion of AMP to adenosine by 5?-nucleotidase, ecto, and compositions containing the compounds and methods for synthesizing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by 5?-nucleotidase, ecto is also provided.

Abstract: The present disclosure is directed to compounds that are inhibitors of HIF-2? having a structure according to Formula I, and compositions containing those compounds. Methods of using the compounds for the treatment of diseases, disorders, or conditions are also described.

Abstract: Compound that inhibit at least one of the A2A and A2B adenosine receptors, and compositions containing the compound and methods for synthesizing the compound, are described herein. Also described are the use of such compounds and compositions for the treatment of a diverse array of diseases, disorders, and conditions, including cancer- and immune-related disorders that are mediated, at least in part, by the adenosine A2A receptor and/or the adenosine A2B receptor.

Abstract: Compounds that inhibit HIF-2?, and compositions containing the compound(s) and methods for synthesizing the compounds, are described herein. Also described are the use of such compounds and compositions for the treatment of a diverse array of diseases, disorders, and conditions, including cancer- and immune-related disorders that are mediated, at least in part, by HIF-2?.

Abstract: Dimensions of a tool moving in/out of a well may be measured during well operations. The measured dimensions of the tool may be used to analyze the well operations. Analysis of well operations may include identification of types of well operations being performed at the well, monitoring of the well operations, benchmarking of the well operations, identification of tools being used in the well operations, and/or other analysis of the well operations.

Abstract: A missile for a hydraulic fracturing system can include a high-pressure (HP) manifold, a low-pressure (LP) manifold, and a main manifold in between. The missile is configured to simultaneously fracture three or more wells. The HP manifold has multiple input channels, an output channel, and a main channel disposed in between. The LP manifold includes a LP input channel, multiple LP output channels, and a LP manifold in between.

Abstract: Compounds of Formula I that inhibit AXL, and compositions containing the compound(s) and methods for synthesizing the compounds, are described herein. Also described are the use of such compounds and compositions for the treatment of a diverse array of diseases, disorders, and conditions, including cancer- and immune-related disorders that are mediated, at least in part, by AXL.