Abstract: Compounds that inhibit KRas G12D. In particular, compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor, and in particular, methods of treating cancer. The compounds have a general structure represented by Formula (I): or a pharmaceutically acceptable salt thereof.

Abstract: A sound-absorbing article (e.g., a tufted sound-absorbing article) can comprise a backing having a thickness and a plurality of face fibers associated with the backing. Optionally, the face fibers can comprise a plurality of tufts extending through the backing. The backing can define a plurality of perforations that fully extend through the thickness of the backing and are provided in a pattern to determine an acoustic property of the sound-absorbing article. Within at least a portion of the backing, sequential perforations within the pattern of the plurality of perforations can be spaced center-to-center by between 5 mm and 100 mm.

Abstract: A sound-absorbing article (e.g., a tufted sound-absorbing article) can comprise a backing having a thickness and a plurality of face fibers associated with the backing. Optionally, the face fibers can comprise a plurality of tufts extending through the backing. The backing can define a plurality of perforations that fully extend through the thickness of the backing and are provided in a pattern to determine an acoustic property of the sound-absorbing article. Within at least a portion of the backing, sequential perforations within the pattern of the plurality of perforations can be spaced center-to-center by between 5 mm and 100 mm.

Abstract: A sound-absorbing article (e.g., a tufted sound-absorbing article) can comprise a backing having a thickness and a plurality of face fibers associated with the backing. Optionally, the face fibers can comprise a plurality of tufts extending through the backing. The backing can define a plurality of perforations that fully extend through the thickness of the backing and are provided in a pattern to determine an acoustic property of the sound-absorbing article. Within at least a portion of the backing, sequential perforations within the pattern of the plurality of perforations can be spaced center-to-center by between 5 mm and 100 mm.

Abstract: A communication system involving an access point, a vehicle and a user is provided. The vehicle and user possess a registration code, the user possesses a public and private key pair, and the access point and vehicle possess certificates and associated private keys. The access point issues a certificate to the user associated with the user's public and private keys, and the certificate of the access point is known and trusted by the vehicle. The access point signs a message granting ownership of the vehicle to the user, and the identity of the user indicates the user's certificate. The vehicle conditionally accepts the ownership registration request of the user.

Abstract: Dual and triple therapy combinations of drugs formulated as brittle matrix particles with a high surface area are provided herein. These particle formulations may be used in inhalation or aerosol administration techniques to provide the drug combinations to the lungs. In some aspects, these compositions may be used to treat a respiratory disease or disorder such as asthma or COPD.

Abstract: A communication system involving an access point, a vehicle and a user is provided. The vehicle and user possess a registration code, the user possesses a public and private key pair, and the access point and vehicle possess certificates and associated private keys. The access point issues a certificate to the user associated with the user's public and private keys, and the certificate of the access point is known and trusted by the vehicle. The access point signs a message granting ownership of the vehicle to the user, and the identity of the user indicates the user's certificate. The vehicle conditionally accepts the ownership registration request of the user.

Abstract: The present invention is a shielding device and method of use that is designed to protect the edge of an article, such as a paper towel roll with a mating inner boundary, from becoming wet or soiled by a user's fingers. The present invention includes a planar base having a first face portion and an opposing second face portion, the first face portion includes a ridge within an outer periphery portion of the base. The second face portion is adjacent to the article, and an extension projects therefrom with a longitudinal axis substantially perpendicular to the planar base. Furthermore, the extension is sized and configured to have an interference fit in relation to being received by the mating inner boundary such that the shielding device and article form a unitary assembly.

Abstract: Inhalable compositions are described. The inhalable compositions comprise one or more respirable aggregates, the respirable aggregates comprising one or more poorly water soluble active agents, wherein at least one of the active agents reaches a maximum lung concentration (Cmax) of at least about 0.25 ?g/gram of lung tissue and remains at such concentration for a period of at least one hour after being delivered to the lung. Methods for making such compositions and methods for using such compositions are also disclosed.

Abstract: An electrically conductive flow field separator plate is disclosed for use in a proton exchange membrane fuel cell. The plate comprises a frame portion, a central planar portion within the frame and a flow field formed in a surface of the central planar portion. The frame portion is elastomeric so as to form a seal with adjacent fuel cell components thereby eliminating the use of separate sealing elements. The frame and the central planar portion are of unitary construction and comprise from about 10 wt. % to about 50 wt. % of elastomer and from about 50 wt. % to about 90 wt. % of conductive filler.

Abstract: A method and apparatus prints copies of internet pages from the worldwide web, in accordance with operator-selected formatting instructions. A plurality of internet page record locators are selected and recorded in memory of the data processing system, preferably grouped in a directory such as a Bookmark, Favorite, or Hotlist directory. Operator-specified formatting instructions are then obtained. The formatting instructions may relate to attributes such as page headers, page footers, page break location, pagination, cover sheets, table of contents, the content allocation and placement among the printed pages, as well as the presence or absence of internet identification titles, and the presence or absence of visually perceptible internet links or internet icons from the Internet pages.

Abstract: In a continuous process for the production of phenol by the oxychlorination of benzene to form chlorination product comprising monochlorobenzene, dichlorobenzene and benzene in a first stage, and the hydrolysis in a second stage with steam of material comprising monochlorobenzene to form hydrolysis product comprising phenol, monochlorobenzene and HCl, the method of separating and recovering phenol therefrom which comprises (1) mixing hydrolysis product comprising phenol and monochlorobenzene with chlorination product comprising monochlorobenzene, dichlorobenzene and benzene, to form liquid organic mixed product, and (2) passing said liquid organic mixed product through a distillation train, in which a benzene fraction, a fraction comprising monochlorobenzene and dichlorobenzene, and a fraction consisting essentially of phenol, ar separated therefrom. The fraction comprising monochlorobenzene and dichlorobenzene is fed to the hydrolysis stage condensation column as quenching material.