Abstract: Dual and triple therapy combinations of drugs formulated as brittle matrix particles with a high surface area are provided herein. These particle formulations may be used in inhalation or aerosol administration techniques to provide the drug combinations to the lungs. In some aspects, these compositions may be used to treat a respiratory disease or disorder such as asthma or COPD.

Abstract: Inhalable compositions are described. The inhalable compositions comprise one or more respirable aggregates, the respirable aggregates comprising one or more poorly water soluble active agents, wherein at least one of the active agents reaches a maximum lung concentration (Cmax) of at least about 0.25 ?g/gram of lung tissue and remains at such concentration for a period of at least one hour after being delivered to the lung. Methods for making such compositions and methods for using such compositions are also disclosed.

Abstract: An electrically conductive flow field separator plate is disclosed for use in a proton exchange membrane fuel cell. The plate comprises a frame portion, a central planar portion within the frame and a flow field formed in a surface of the central planar portion. The frame portion is elastomeric so as to form a seal with adjacent fuel cell components thereby eliminating the use of separate sealing elements. The frame and the central planar portion are of unitary construction and comprise from about 10 wt. % to about 50 wt. % of elastomer and from about 50 wt. % to about 90 wt. % of conductive filler.