Patents by Inventor Jay R. Luly

Jay R. Luly has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 5, 6-Duridine nucleoside/tide derivatives
    Patent number: 10034893
    Abstract: In one aspect, the invention provides compounds represented by Formula I, and pharmaceutically acceptable salts, esters, stereoisomers, tautomers, solvates, and combinations thereof, pharmaceutical compositions comprising these compounds and the use of these compounds for treating a viral infection in a subject.
    Type: Grant
    Filed: January 31, 2014
    Date of Patent: July 31, 2018
    Assignee: ENANTA PHARMACEUTICALS, INC.
    Inventors: Jay R. Luly, Jun Ma, Guoqiang Wang, Yat Sun Or
  • Deuterated nucleoside/tide derivatives
    Patent number: 9718851
    Abstract: The present invention provides nucleoside phosphoramidate compounds of Formula I, where R1, R2a, R2b, R4, R5a, R5b, Rb5, Rb6 and D are as defined herein. The invention further includes pharmaceutical compositions comprising a compound of Formula I, methods of use of these compounds for treating a viral infection, and methods of producing these compounds.
    Type: Grant
    Filed: November 5, 2015
    Date of Patent: August 1, 2017
    Assignee: Enanta Pharmaceuticals, Inc.
    Inventors: Jay R. Luly, Bin Wang, Guoqiang Wang, Yat Sun Or
  • Chemokine receptor antagonists and methods of use
    Patent number: 9663537
    Abstract: Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by: or physiologically acceptable salt thereof.
    Type: Grant
    Filed: March 10, 2015
    Date of Patent: May 30, 2017
    Assignees: Millennium Pharmaceuticals, Inc., Kyowa Hakko Kirin Co., Ltd.
    Inventors: Jay R. Luly, Yoshisuke Nakasato, Etsuo Ohshima, Geraldine C. B. Harriman, Kenneth G. Carson, Shomir Ghosh, Amy M. Elder, Karen M. Mattia
  • DEUTERATED NUCLEOSIDE/TIDE DERIVATIVES
    Publication number: 20160130294
    Abstract: The present invention provides nucleoside phosphoramidate compounds of Formula I, where R1, R2a, R2b, R4, R5a, R5b, Rb5, Rb6 and D are as defined herein. The invention further includes pharmaceutical compositions comprising a compound of Formula I, methods of use of these compounds for treating a viral infection, and methods of producing these compounds.
    Type: Application
    Filed: November 5, 2015
    Publication date: May 12, 2016
    Inventors: Jay R. Luly, Bin Wang, Guoqiang Wang, Yat Sun Or
  • CHEMOKINE RECEPTOR ANTAGONISTS AND METHODS OF USE THEREOF
    Publication number: 20160031908
    Abstract: Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by: or physiologically acceptable salt thereof.
    Type: Application
    Filed: March 10, 2015
    Publication date: February 4, 2016
    Inventors: Jay R. LULY, Yoshisuke NAKASATO, Etsuo OHSHIMA, Geraldine C.B. HARRIMAN, Kenneth G. CARSON, Shomir GHOSH, Amy M. ELDER, Karen M. MATTIA
  • CHEMOKINE RECEPTOR ANTAGONISTS AND METHODS OF USE THEREOF
    Publication number: 20140371207
    Abstract: Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by: or physiologically acceptable salt thereof.
    Type: Application
    Filed: December 13, 2013
    Publication date: December 18, 2014
    Applicants: Kyowa Hakko Kirin Co., Ltd., Millennium Pharmaceuticals, Inc.
    Inventors: Jay R. Luly, Yoshisuke Nakasato, Etsuo Ohshima, Geraldine C.B. Harriman, Kenneth G. Carson, Shomir Ghosh, Amy M. Elder, Karen M. Mattia
  • 5, 6-D2 URIDINE NUCLEOSIDE/TIDE DERIVATIVES
    Publication number: 20140219958
    Abstract: In one aspect, the invention provides compounds represented by Formula I, and pharmaceutically acceptable salts, esters, stereoisomers, tautomers, solvates, and combinations thereof, pharmaceutical compositions comprising these compounds and the use of these compounds for treating a viral infection in a subject.
    Type: Application
    Filed: January 31, 2014
    Publication date: August 7, 2014
    Applicant: ENANTA PHARMACEUTICALS, INC.
    Inventors: Jay R. Luly, Jun Ma, Guoqiang Wang, Yat Sun Or
  • Chemokine receptor antagonists and methods of use thereof
    Patent number: 8653096
    Abstract: Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by: or physiologically acceptable salt thereof.
    Type: Grant
    Filed: September 26, 2011
    Date of Patent: February 18, 2014
    Assignees: Millennium Pharmaceuticals, Inc., Kyowa Hakko Kirin Co., Ltd.
    Inventors: Jay R. Luly, Yoshisuke Nakasato, Etsuo Ohshima, Geraldine C. B. Harriman, Kenneth G. Carson, Shomir Ghosh, Amy M. Elder, Karen M. Mattia
  • CHEMOKINE RECEPTOR ANTAGONISTS AND METHODS OF USE THEREOF
    Publication number: 20120046311
    Abstract: Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by: or physiologically acceptable salt thereof.
    Type: Application
    Filed: September 26, 2011
    Publication date: February 23, 2012
    Applicant: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Jay R. Luly, Yoshisuke Nakasato, Etsuo Ohshima, Geraldine C. B. Harriman, Kenneth G. Carson, Shomir Ghosh, Amy M. Elder, Karen M. Mattia
  • Chemokine receptor antagonists and methods of use therefor
    Patent number: 8058287
    Abstract: Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by: or physiologically acceptable salt thereof.
    Type: Grant
    Filed: May 6, 2009
    Date of Patent: November 15, 2011
    Assignees: Millennium Pharmaceuticals, Inc., Kyowa Hakko Kirin Co., Ltd.
    Inventors: Jay R. Luly, Yoshisuke Nakasato, Etsuo Ohshima, Geraldine C. B. Harriman, Kenneth G. Carson, Shomir Ghosh, Amy M. Elder, Karen M. Mattia
  • CHEMOKINE RECEPTOR ANTAGONISTS AND METHODS OF USE THEREFOR
    Publication number: 20090281081
    Abstract: Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by: or physiologically acceptable salt thereof.
    Type: Application
    Filed: May 6, 2009
    Publication date: November 12, 2009
    Inventors: Jay R. Luly, Yoshisuke Nakasato, Etsuo Ohshima, Geraldine C. B. Harriman, Kenneth G. Carson, Shomir Ghosh, Amy M. Elder, Karen M. Mattia
  • Chemokine receptor antagonists and methods of use therefor
    Patent number: 7541365
    Abstract: Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by: or physiologically acceptable salt thereof.
    Type: Grant
    Filed: November 10, 2006
    Date of Patent: June 2, 2009
    Assignees: Millennium Pharmaceuticals, Inc., Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Jay R. Luly, Yoshisuke Nakasato, Etsuo Ohshima, Geraldine C. B. Harriman, Kenneth G. Carson, Shomir Ghosh, Amy M. Elder, Karen M. Mattia
  • Chemokine receptor antagonists and methods of use thereof
    Patent number: 7271176
    Abstract: Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation.
    Type: Grant
    Filed: November 13, 2002
    Date of Patent: September 18, 2007
    Assignees: Millennium Pharmaceuticals, Inc., Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Jay R. Luly, Yoshisuke Nakasato, Etsuo Ohshima, Geraldine C. B. Harriman, Kenneth G. Carson, Shomir Ghosh, Amy M. Elder, Karen M. Mattia
  • Chemokine receptor antagonists and methods of use thereof
    Patent number: 7186729
    Abstract: Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation.
    Type: Grant
    Filed: November 13, 2002
    Date of Patent: March 6, 2007
    Assignees: Millennium Pharmaceuticals, Inc., Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Jay R. Luly, Yoshisuke Nakasato, Etsuo Ohshima, Geraldine C. B. Harriman, Kenneth G. Carson, Shomir Ghosh, Amy M. Elder, Karen M. Mattia
  • Barbiturates as integrin antagonists and their use for treating inflammatory diseases
    Publication number: 20040214845
    Abstract: The invention relates to a pharmaceutical composition comprising a compound of the formula (I): 1
    Type: Application
    Filed: May 19, 2004
    Publication date: October 28, 2004
    Applicant: Millennium Pharmaceuticals, Inc.
    Inventors: Marc Bazin, Geraldine C. Harriman, Cyrille Kuhn, Jay R. Luly
  • Imidazolidine compounds
    Publication number: 20040127507
    Abstract: Disclosed are novel compounds and a method of treating inflammatory diseases.
    Type: Application
    Filed: December 9, 2003
    Publication date: July 1, 2004
    Applicants: Millennium Pharmaceuticals, Inc., Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Etsuo Ohshima, Hiroki Sone, Osamu Kotera, Jay R. Luly, Gregory J. LaRosa
  • Imidazolidine compounds
    Publication number: 20040122026
    Abstract: Disclosed are novel compounds and a method of treating inflammatory diseases.
    Type: Application
    Filed: December 9, 2003
    Publication date: June 24, 2004
    Applicants: Millennium Pharmaceuticals, Inc., Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Etsuo Ohshima, Hiroki Sone, Osamu Kotera, Jay R. Luly, Gregory J. LaRosa
  • Imidazolidine compounds
    Publication number: 20030225288
    Abstract: Disclosed are novel compounds and a method of treating inflammatory diseases.
    Type: Application
    Filed: April 12, 2002
    Publication date: December 4, 2003
    Applicants: Millennium Pharmaceuticals, Inc., Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Etsuo Ohshima, Hiroki Sone, Osamu Kotera, Jay R. Luly, Gregory J. LaRosa
  • Chemokine receptor antagonists and methods of use therefor
    Patent number: 6613905
    Abstract: Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by the following structural formula: and physiologically acceptable salts thereof.
    Type: Grant
    Filed: September 4, 1998
    Date of Patent: September 2, 2003
    Assignees: Millennium Pharmaceuticals, Inc., Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Jay R. Luly, Yoshisuke Nakasato, Etsuo Ohshima
  • Barbiturates as integrin antagonists and their use for treating inflammatory diseases
    Publication number: 20030105119
    Abstract: The invention relates to a pharmaceutical composition comprising a compound of the formula (I): 1
    Type: Application
    Filed: February 22, 2002
    Publication date: June 5, 2003
    Inventors: Marc Bazin, Geraldine C. Harriman, Cyrille Kuhn, Jay R. Luly