Abstract: Automated workpiece transfer systems and methods of implementing thereof are disclosed. The system can include an imaging device operable to capture an initial image of workpieces loaded onto a loading area; an autonomous pick-and-place robot, and a processor in communication with the imaging device and the pick-and-place robot. The autonomous pick-and-place robot can include an end-of-arm-tooling component operable to retrieve pickable workpieces from the loading area and transfer the pickable workpieces to a receiving area according to a set of operating parameters. The processor can be operable to apply a machine-learning model to the initial image to identify pickable workpieces; identify a region of interest within the initial image; and based on the initial image, define the set of operating parameters for operating the end-of-arm-tooling component to retrieve the one or more pickable workpieces.