Patents by Inventor Jay Stearns

Jay Stearns has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for making 3.alpha.-hydroxy, 3.beta.-substituted-pregnanes
    Patent number: 5319115
    Abstract: This invention provides a simplified method for converting pregnan-3,20-dione compounds to 3.alpha.-hydroxy,3.beta.-substituted-pregnanes. By selective use of reagents the unprotected dione is converted chemoselectively and diastereoselectively into a 3(R)-pregnan-3-spiro-2'oxirane-20-one intermediate. This intermediate can then be converted regioselectively by a second set of reactions to the 3.alpha.-hydroxy,3.beta.-substituted-20-one form, which can be further modified at the 20-keto position.Through this method, each ketone group is independently treated. By modifying the ketones one at a time, one can obtain the desired stereo-specificity at each site.
    Type: Grant
    Filed: March 4, 1992
    Date of Patent: June 7, 1994
    Assignee: Cocensys Inc.
    Inventors: Hasan Tahir, Michael Bolger, Richard Buswell, Richard Gabriel, Jay Stearns