Abstract: The invention provides a fiber having different morphology and a method of making such fiber in a predictable manner. The method includes providing a first component including water, wherein the first component has a first evaporation rate, providing a second component including a polymer, wherein the second component has a second evaporation rate, provided that the second evaporation rate is higher than the first evaporation rate, combining the first component and the second component to make an emulsion, applying a force to the emulsion, and extruding the emulsion to make the fiber, wherein the fiber has an outer surface, an internal cavity and a diameter of at most 10 micrometers.

Abstract: In one aspect, the invention relates to a synthetic conduit comprising a substantially tubular body comprising substantially circumferential polymer fibers; wherein the body has an exterior surface, an interior surface, and a lumen extending therethrough; and wherein the body has microscale features disposed at the interior surface. In a further aspect, cells can be optionally adhered to the exterior and/or interior surface of the substantially tubular body. In various aspects, the conduit can be used as a vascular prosthesis, a stent, or a nerve regeneration scaffold. Methods of preparing and implanting same are also provided. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.