Patents by Inventor Jay Trautman

Jay Trautman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200377933
    Abstract: Disclosed herein are compositions, kits, methods, and systems for detecting a target molecule in a sample using a detection molecule.
    Type: Application
    Filed: July 27, 2020
    Publication date: December 3, 2020
    Inventors: Jay TRAUTMAN, Gordon WANG, David LENZI
  • Publication number: 20200375580
    Abstract: Devices and systems for analyzing biological samples are provided. Devices include a hollow body extending from a first end to a second end. The body defines a sample collecting portion. A first opening at the first end of the body is operable to receive a source of negative pressure and a second opening at the second end of the body is operable to receive a biological sample. The body also includes an optically transparent region disposed in a region corresponding to the sample collecting portion, the optically transparent region being configured to transmit electromagnetic radiation therethrough from an imaging device capable of imaging the biological sample when disposed in the sample collecting portion.
    Type: Application
    Filed: August 14, 2020
    Publication date: December 3, 2020
    Applicants: THE REGENTS OF THE UNIVERSITY OF MICHIGAN, INVENIO IMAGING, INC.
    Inventors: Daniel ORRINGER, Christian FREUDIGER, Jay TRAUTMAN, Andrew KELLY
  • Patent number: 10781477
    Abstract: Disclosed herein are compositions, kits, methods, and systems for detecting a target molecule in a sample using a detection molecule.
    Type: Grant
    Filed: January 23, 2019
    Date of Patent: September 22, 2020
    Assignee: ARATOME, LLC
    Inventors: Jay Trautman, Gordon Wang, David Lenzi
  • Patent number: 10743848
    Abstract: Devices and systems for analyzing biological samples are provided. Devices include a hollow body extending from a first end to a second end. The body defines a sample collecting portion. A first opening at the first end of the body is operable to receive a source of negative pressure and a second opening at the second end of the body is operable to receive a biological sample. The body also includes an optically transparent region disposed in a region corresponding to the sample collecting portion, the optically transparent region being configured to transmit electromagnetic radiation therethrough from an imaging device capable of imaging the biological sample when disposed in the sample collecting portion.
    Type: Grant
    Filed: September 23, 2016
    Date of Patent: August 18, 2020
    Assignees: THE REGENTS OF THE UNIVERSITY OF MICHIGAN, INVENIO IMAGING, INC.
    Inventors: Daniel Orringer, Christian Freudiger, Jay Trautman, Andrew Kelly
  • Publication number: 20190346368
    Abstract: Provided herein are devices, systems, and methods for detection of sensors, such as light-detectable sensors. The devices or systems as described herein may comprise an illumination assembly configured to direct a light to at least a well of a plurality of wells in the array of wells and a detection assembly configured to detect a signal from the well.
    Type: Application
    Filed: January 10, 2018
    Publication date: November 14, 2019
    Inventors: Andrew BLATZ, Thomas LILA, Jay TRAUTMAN
  • Publication number: 20190153522
    Abstract: Disclosed herein are compositions, kits, methods, and systems for detecting a target molecule in a sample using a detection molecule.
    Type: Application
    Filed: January 23, 2019
    Publication date: May 23, 2019
    Inventors: Jay TRAUTMAN, Gordon WANG, David LENZI
  • Publication number: 20180263606
    Abstract: Devices and systems for analyzing biological samples are provided. Devices include a hollow body extending from a first end to a second end. The body defines a sample collecting portion. A first opening at the first end of the body is operable to receive a source of negative pressure and a second opening at the second end of the body is operable to receive a biological sample. The body also includes an optically transparent region disposed in a region corresponding to the sample collecting portion, the optically transparent region being configured to transmit electromagnetic radiation therethrough from an imaging device capable of imaging the biological sample when disposed in the sample collecting portion.
    Type: Application
    Filed: September 23, 2016
    Publication date: September 20, 2018
    Applicants: THE REGENTS OF THE UNIVERSITY OF MICHIGAN, INVENIO IMAGING, INC.
    Inventors: Daniel ORRINGER, Christian FREUDIGER, Jay TRAUTMAN, Andrew KELLY
  • Publication number: 20170307627
    Abstract: The present invention provides labeling method for Array Tomography (AT) and immunohistochemistry (IHC) that enables automated analysis many tens-to-hundreds of proteins in a manner that minimizes tissue degradation, increases data fidelity, and substantially increases throughput and reduces cost. Also included are methods for automated acquisition of AT and IHC data.
    Type: Application
    Filed: April 6, 2017
    Publication date: October 26, 2017
    Inventors: Gordon WANG, Jay TRAUTMAN
  • Publication number: 20130344500
    Abstract: Described herein are tissue adhesive substrates and methods of making such substrates. Tissue adhesive substrates comprise a glass substrate and a silane covalently bound to the glass substrate. In some variations, the silane may be an amino silane, and may comprise an aryl or an alkyl moiety. In other variations, the silane may be coated with carbon. Silanes may be deposited onto the glass substrate by vapor deposition. Tissue adhesive substrates comprising carbon-coated silanized glass substrates may be capable of retaining a tissue section through multiple cycles of antibody staining and stripping without discernible or substantial damage to the tissue section. In addition, carbon-coated tissue adhesive substrates may also provide a fiduciary marker for closed-loop autofocussing mechanisms.
    Type: Application
    Filed: March 14, 2013
    Publication date: December 26, 2013
    Applicant: Aratome, LLC
    Inventors: Jay Trautman, David P. Lenzi
  • Publication number: 20100330607
    Abstract: The present invention provides a system for assaying ion-channels. In some embodiments, the ion-channel assay provides a reversible change to the membrane potential of a target, e.g., a cell, upon exposure to light. In some embodiments, the membrane potential readout is fed back through a control circuit to regulate the excitation intensity of the illumination sources that induce, respectively, hyperpolarizing and depolarizing currents, thereby effecting closed-loop control of the membrane potential.
    Type: Application
    Filed: June 23, 2010
    Publication date: December 30, 2010
    Applicant: Photoswitch Biosciences, Inc.
    Inventors: Jay Trautman, Andrew Blatz
  • Publication number: 20060234332
    Abstract: Cell based assays are used to assess the hepatotoxicity of a stimulus. Imaging technologies are used to analyze the effects of a stimulus on hepatocytes. Image analysis may characterize the stimulus on the basis of whether it is hepatotoxic, and if so what type of pathology is exhibited; e.g., apoptosis, necrosis, cholestasis, and/or steatosis.
    Type: Application
    Filed: March 13, 2006
    Publication date: October 19, 2006
    Inventors: Larry Mattheakis, Jay Trautman, Gregg Solar, Jinhong Fan, Eugeni Vaisberg, Cynthia Adams, Aibing Rao
  • Publication number: 20060228695
    Abstract: Cell based assays are used to assess the hepatotoxicity of a stimulus. Imaging technologies are used to analyze the effects of a stimulus on hepatocytes. Image analysis may characterize the stimulus on the basis of whether it is hepatotoxic, and if so what type of pathology is exhibited; e.g., apoptosis, necrosis, cholestasis, and/or steatosis.
    Type: Application
    Filed: March 13, 2006
    Publication date: October 12, 2006
    Inventors: Larry Mattheakis, Jay Trautman, Gregg Solar, Jinhong Fan, Eugeni Vaisberg, Cynthia Adams, Aibing Rao
  • Publication number: 20060116369
    Abstract: Compounds useful for treating cellular proliferative diseases are disclosed.
    Type: Application
    Filed: October 24, 2005
    Publication date: June 1, 2006
    Inventors: Shyamlal Ramchandani, Reginald De La Rosa, Cynthia Adams, Gustave Bergnes, David Morgans, Jay Trautman
  • Publication number: 20050282838
    Abstract: Compounds useful for treating cellular proliferative diseases are disclosed.
    Type: Application
    Filed: October 15, 2004
    Publication date: December 22, 2005
    Inventors: Shyamlal Ramchandani, Reginald Norman Rosa, Cynthia Adams, Gustave Bergnes, David Morgans, Jay Trautman
  • Publication number: 20050014217
    Abstract: Cell based assays are used to assess the hepatotoxicity of a stimulus. Imaging technologies are used to analyze the effects of a stimulus on hepatocytes. Image analysis may characterize the stimulus on the basis of whether it is hepatotoxic, and if so what type of pathology is exhibited; e.g., apoptosis, necrosis, cholestasis, and/or steatosis.
    Type: Application
    Filed: November 20, 2003
    Publication date: January 20, 2005
    Inventors: Larry Mattheakis, Jay Trautman, Gregg Solar, Jinhong Fan, Eugeni Vaisberg, Cynthia Adams, Aibing Rao
  • Publication number: 20050014216
    Abstract: Cell based assays are used to assess the hepatotoxicity of a stimulus. Imaging technologies are used to analyze the effects of a stimulus on hepatocytes. Image analysis may characterize the stimulus on the basis of whether it is hepatotoxic, and if so what type of pathology is exhibited; e.g., apoptosis, necrosis, cholestasis, and/or steatosis.
    Type: Application
    Filed: July 18, 2003
    Publication date: January 20, 2005
    Inventors: Larry Mattheakis, Jay Trautman, Gregg Solar, Jinhong Fan, Eugeni Vaisberg, Cynthia Adams, Aibing Rao