Abstract: Therapeutic compounds for red blood cell-mediated delivery of an active pharmaceutical ingredient to a target cell are described. The therapeutic compounds are configured to bind CD47 on the surface of a red blood cell and to be subsequently transferred to CD47 on the surface of the target cell, the therapeutic compound ultimately being internalized by the target cell via endocytosis. The target cell may be a fibrotic cell.

Abstract: The present invention relates to a heating system using a fireplace which includes a combustion room having a discharge hole installed at the wall body of a dwelling house comprises a water tank installed within the combustion room of the fireplace and having water therein; and a pipe with a predetermined length flatly placed with a zigzag type under the bottom surface with a constant area at the neighborhood of the fireplace, the inlet and outlet of the pipe communicated with a side of the water tank, which the water discharged from the water tank through the inlet is circulated along the pipe with a predetermined length, then returned to the water tank through the outlet of the pipe, whereby the warmth at the bottom surface of the room is maintained by the circulated warm water.