Patents by Inventor Jaya Pratap Pinnamaneni

Jaya Pratap Pinnamaneni has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DIRECT REPROGRAMMING OF CARDIAC FIBROBLASTS INTO CARDIOMYOCYTES USING AN ENDOTHELIAL CELL TRANSDIFFERENTIATION STRATEGY
    Publication number: 20220143142
    Abstract: Embodiments of the disclosure provide methods and compositions related to improving cardiomyocyte production by exposing starting cells to ETV2 and/or VEGF. The starting cells in specific embodiments are fibroblasts and/or endothelial cells, and following exposure to ETV2 and/or VEGF the resultant cells are exposed to one or more cardiomyocyte transdifferentiation factors, such as GATA4, myocyte enhancer factor-2c (Mef2c), T-box transcription factor 5 (TBX5), or a combination thereof. The produced cardiomyocytes are provided to individuals in need thereof, in particular embodiments.
    Type: Application
    Filed: March 17, 2020
    Publication date: May 12, 2022
    Inventors: Megumi Mathison, Todd Rosengart, Vivek P. Singh, Deepthi Sanagasetti, Jaya Pratap Pinnamaneni, Jianchang Yang