Patents by Inventor Jayakumar Rajadas

Jayakumar Rajadas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210283148
    Abstract: Enema compositions containing corticosteroids or salicylic acid derivatives are disclosed. The compositions are liquid at room temperature but turn to gels at body temperature. They are useful for treating inflammatory bowel disease.
    Type: Application
    Filed: May 27, 2021
    Publication date: September 16, 2021
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Sidhartha Ranjit SINHA, Jayakumar RAJADAS, Aida HABTEZION, Ravinder D. PAMNANI
  • Publication number: 20210268248
    Abstract: Embodiment provided herein are directed to microneedle patches for agent application on a mammal skin. The microneedle patch may comprise a patch scaffold having a surface, and a plurality of microneedles disposed on the surface. Each of the microneedles may be capable of piercing the skin 50 ?m to 1000 ?m deep, and comprises a composite material comprising polyvinylpyrrolidone (PVP) and one or more additional copolymers selected from the group consisting of maltose, leucine, and dileucine.
    Type: Application
    Filed: May 19, 2021
    Publication date: September 2, 2021
    Inventors: Mohamed R. Ahmed, Jayakumar Rajadas, Wenchao Sun, Mohammed Inayathullah Nazir Ahmed, Feng Xu
  • Patent number: 11013899
    Abstract: Embodiment provided herein are directed to microneedle patches for agent application on a mammal skin. The microneedle patch may comprise a patch scaffold having a surface, and a plurality of microneedles disposed on the surface. Each of the microneedles may be capable of piercing the skin 50 ?m to 1000 ?m deep, and comprises a composite material comprising polyvinylpyrrolidone (PVP) and one or more additional copolymers selected from the group consisting of maltose, leucine, and dileucine.
    Type: Grant
    Filed: June 4, 2018
    Date of Patent: May 25, 2021
    Assignee: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
    Inventors: Mohamed R. Ahmed, Jayakumar Rajadas, Wenchao Sun, Mohammed Inayathullah Nazir Ahmed, Feng Xu
  • Publication number: 20210059990
    Abstract: Disclosed herein are methods and drug compositions for treating Lyme disease and post-treatment Lyme disease syndrome (PTLDS) or chronic Lyme disease (CLD). In one embodiment, a method of treating a subject with Lyme disease involves administering an effective amount of a therapeutic agent selected from the group consisting of tetraethylthiuram disulfide, doxorubicin, epirubicin, azlocillin, cephalothin, josamycin, cefotaxime, cefazolin, erythromycin, calcimycin, gramicidin, cefdinir, gambogic acid, ceftazidime, ticarcillin, valinomycin, moxifloxacin, linezolid, idarubicin, tosufloxacin, loratadine, ceftriaxone, and combinations thereof, and pharmaceutical salts, hydrates, and solvates thereof.
    Type: Application
    Filed: November 13, 2020
    Publication date: March 4, 2021
    Inventors: Jayakumar Rajadas, Venkata Raveendra Pothineni, Mohammed Inayathullah Nazir Ahmed
  • Publication number: 20200338024
    Abstract: Compositions and methods are provided for the prevention and treatment of chronic wounds, including, without limitation, pressure ulcers and diabetic ulcers, by transdermal delivery of an agent that increases activity of HIF-1 a in the wound.
    Type: Application
    Filed: July 8, 2020
    Publication date: October 29, 2020
    Inventors: Geoffrey C. GURTNER, Jayakumar RAJADAS, Michael Gabriel GALVEZ, Evgenios NEOFYTOU
  • Publication number: 20200283730
    Abstract: The present disclosure describes systems and methods capable of automated processing of signals from cardiomyocytes in an unbiased manner. Embodiments of the present disclosure are directed to analyzing signal traces derived from cardiomyocytes that provide more accurate and reliable information. Additional embodiments are directed to assessing disease mechanisms and/or treatment plans for an individual based on cardiomyocyte function, and further embodiments are directed to treating an individual based on cardiomyocyte function.
    Type: Application
    Filed: March 6, 2020
    Publication date: September 10, 2020
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Jayakumar Rajadas, Joseph Wu, Andrey Victorovich Malkovskiy
  • Patent number: 10751304
    Abstract: Compositions and methods are provided for the prevention and treatment of chronic wounds, including, without limitation, pressure ulcers and diabetic ulcers, by transdermal delivery of an agent that increases activity of HIF-1? in the wound.
    Type: Grant
    Filed: September 11, 2018
    Date of Patent: August 25, 2020
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Geoffrey C. Gurtner, Jayakumar Rajadas, Michael Gabriel Galvez, Evgenios Neofytou
  • Publication number: 20200054556
    Abstract: The disclosure relates generally to compositions comprising pegylated liposomal formulations of apelin for the treatment of cardiovascular-related diseases.
    Type: Application
    Filed: October 19, 2017
    Publication date: February 20, 2020
    Inventor: Jayakumar RAJADAS
  • Patent number: 10548860
    Abstract: Formulations and methods are provided for improving the function, i.e. clinical outcome, of solid organ transplants. Lung transplantation is of particular interest. In the methods of the invention, a nanoparticle formulation comprising an effective dose of an iron chelator active agent in nanoparticle form, including without limitation, deferoxamine (DFO), deferasirox (DFX), and deferiprone (DFP), etc. suspended in a carrier compatible with the tissue of interest, is topically applied to the surface of tissues at the site of anastomosis. The nanoparticles are comprised of the active agent and a pharmaceutically acceptable stabilizer.
    Type: Grant
    Filed: January 29, 2019
    Date of Patent: February 4, 2020
    Assignees: The Board Of Trustees of The Leland Stanford Junior University, The United States Government as Represented By The Department Of Veterans Affairs, The Johns Hopkins University
    Inventors: Mark R. Nicolls, Jayakumar Rajadas, Geoffrey C. Gurtner, Xinguo Jiang, Gundeep Dhillon, Gregg L. Semenza
  • Publication number: 20200009038
    Abstract: The present invention provides threads of hyaluronic acid, and/or derivatives thereof, methods of making thereof and uses thereof, for example, in aesthetic applications (e.g., dermal fillers), surgery (sutures), drug delivery, etc.
    Type: Application
    Filed: August 30, 2019
    Publication date: January 9, 2020
    Inventors: Geoffrey C. GURTNER, Kenneth N. HORNE, Jayakumar RAJADAS
  • Patent number: 10527577
    Abstract: Improved electrochemical impedance spectroscopy assays are provided by electrodepositing metallic nanoparticles onto the working electrode for electrochemical impedance spectroscopy. The metallic nanoparticles provide improved assay sensitivity. Electrodeposition of the metallic nanoparticles firmly affixes them to the working electrode, thereby making it easier to clean the working electrode from one assay to the next assay without undesirably removing the metallic nanoparticles.
    Type: Grant
    Filed: July 18, 2017
    Date of Patent: January 7, 2020
    Assignees: The Board of Trustees of the Leland Stanford Junior University, The United States of America as represented by the Department of Veteran Affairs (Washington DC)
    Inventors: Preetha Jothimuthu, Mohammed Inayathullah Nazir Ahmed, Wen A. Tian, Jayakumar Rajadas, Mark Nicolls, JooChuan Ang
  • Publication number: 20190388348
    Abstract: Compositions and methods for treating cardiovascular and pulmonary diseases and disorders with apelin are disclosed. In particular, the invention relates to formulations comprising apelin encapsulated in liposome nanocarriers conjugated with polyethylene glycol (PEG) and their use in treatment of cardiovascular and pulmonary diseases and disorders. Encapsulation of apelin in PEG-conjugated liposomes significantly enhances efficacy, improves cellular uptake of apelin, and allows for sustained and extended release of apelin under physiological conditions.
    Type: Application
    Filed: May 1, 2019
    Publication date: December 26, 2019
    Inventors: Jayakumar RAJADAS, Pilar RUIZ-LOZANO, Vahid SERPOOSHAN
  • Patent number: 10463595
    Abstract: The present invention provides threads of hyaluronic acid, and/or derivatives thereof, methods of making thereof and uses thereof, for example, in aesthetic applications (e.g., dermal fillers), surgery (sutures), drug delivery, etc.
    Type: Grant
    Filed: January 8, 2018
    Date of Patent: November 5, 2019
    Assignee: ALLERGAN HOLDINGS FRANCE S.A.S.
    Inventors: Geoffrey C. Gurtner, Kenneth N. Horne, Jayakumar Rajadas
  • Patent number: 10426403
    Abstract: A method of testing for specificity and strength of an allergic reaction is performed by penetrating the skin of an individual with the microneedle array comprising a plurality of epitopes and determining the response of the skin to the allergens. The response can be measured with a thermal imaging device. Analysis, and optionally treatment, can be provided to the individual.
    Type: Grant
    Filed: May 8, 2014
    Date of Patent: October 1, 2019
    Assignee: The Board of Trustees of The Leland Stanford Junior University
    Inventors: Manish J. Butte, Jayakumar Rajadas
  • Patent number: 10370400
    Abstract: This disclosure presents 4-MUG derivatives (e.g., 4-MUG ester prodrugs) that reduce or prevent HA synthesis. In some embodiments, the 4-MUG derivatives of the present disclosure can be used to suppress HA synthesis and curtail inflammation.
    Type: Grant
    Filed: January 12, 2018
    Date of Patent: August 6, 2019
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Nadine Nagy, Jayakumar Rajadas, Paul Bollyky
  • Publication number: 20190192452
    Abstract: Formulations and methods are provided for improving the function, i.e. clinical outcome, of solid organ transplants. Lung transplantation is of particular interest. In the methods of the invention, a nanoparticle formulation comprising an effective dose of an iron chelator active agent in nanoparticle form, including without limitation, deferoxamine (DFO), deferasirox (DFX), and deferiprone (DFP), etc. suspended in a carrier compatible with the tissue of interest, is topically applied to the surface of tissues at the site of anastomosis. The nanoparticles are comprised of the active agent and a pharmaceutically acceptable stabilizer.
    Type: Application
    Filed: January 29, 2019
    Publication date: June 27, 2019
    Inventors: Mark R. Nicolls, Jayakumar Rajadas, Geoffrey C. Gurtner, Xinguo Jiang, Gundeep Dhillon, Gregg L. Semenza
  • Patent number: 10220009
    Abstract: Formulations and methods are provided for improving the function, i.e. clinical outcome, of solid organ transplants. Lung transplantation is of particular interest. In the methods of the invention, a nanoparticle formulation comprising an effective dose of an iron chelator active agent in nanoparticle form, including without limitation, deferoxamine (DFO), deferasirox (DFX), and deferiprone (DFP), etc. suspended in a carrier compatible with the tissue of interest, is topically applied to the surface of tissues at the site of anastomosis. The nanoparticles are comprised of the active agent and a pharmaceutically acceptable stabilizer.
    Type: Grant
    Filed: August 30, 2013
    Date of Patent: March 5, 2019
    Assignees: The Board of Trustees of the Leland Stanford Junior University, The Johns Hopkins University, The United States of America as Represented by the Department of Veterans Affairs
    Inventors: Mark R. Nicolls, Jayakumar Rajadas, Geoffrey C. Gurtner, Xinguo Jiang, Gundeep Dhillon, Gregg L. Semenza
  • Publication number: 20190060506
    Abstract: The present disclosure provides methods and apparatuses for treating tissue ulcers. The apparatuses include elafin protein incorporated into a biocompatible matrix that allows controlled release of the elafin protein to the wound. The biocompatible matrix may be made of biological polymers such as collagen.
    Type: Application
    Filed: August 21, 2018
    Publication date: February 28, 2019
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Mohamed R. Ahmed, Jayakumar Rajadas, Mohammed Inayathullah Nazir Ahmed, Wenchao Sun, Mark R. Nicolls
  • Publication number: 20190054051
    Abstract: The present disclosure provides compositions and methods for preventing and treating dyskinesia, such as drug-induced dyskinesia in patients of Parkinson's disease. The compositions, preferably in a sustained release formulation, include L-DOPA, carbidopa, and ranitidine wherein the weight ratio of L-DOPA to carbidopa is in the range of about 1:(0.2-0.3), or include L-DOPA, benserazide, and ranitidine, wherein the weight ratio of L-DOPA to benserazide is in the range of about 1:(0.4-0.6).
    Type: Application
    Filed: August 21, 2018
    Publication date: February 21, 2019
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Mohamed Ahmed, Jayakumar Rajadas, Mohammed Inayathullah Nazir Ahmed, Wenchao Sun
  • Publication number: 20190008807
    Abstract: Compositions and methods are provided for the prevention and treatment of chronic wounds, including, without limitation, pressure ulcers and diabetic ulcers, by transdermal delivery of an agent that increases activity of HIF-1? in the wound.
    Type: Application
    Filed: September 11, 2018
    Publication date: January 10, 2019
    Inventors: Geoffrey C. Gurtner, Jayakumar Rajadas, Michael Gabriel Galvez, Evgenios Neofytou