Patents by Inventor Jayalakshmi Gosala

Jayalakshmi Gosala has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for Achieving High-Level Expression of Recombinant Human Interleukin-2 Upon Destabilization of the Rna Secondary Structure
    Publication number: 20080268503
    Abstract: The present invention provides a method for achieving high-level expression of the therapeutically important lymphokine (human IL-2). The method comprises of identifying the secondary structure in the 5? region of human IL-2 mRNA, modifying the 5? region of the human IL-2 DNA sequence to produce a new DNA sequence wherein the mRNA transcribed from the modified human IL-2 DNA sequence has the predicted 5? secondary structure destabilized with increased free energy compared to that of the secondary structure of the mRNA transcribed from the native DNA sequence without altering the sequence of the encoded amino acids; and using this modified DNA sequence of human IL-2 for high level recombinant expression in a microbial host for large scale production. This method is also applicable to other expression host like yeasts and mammalian cells.
    Type: Application
    Filed: March 17, 2006
    Publication date: October 30, 2008
    Applicant: ZENOTECH LABORATORIES LIMITED
    Inventors: Mitali Samaddar, Sheeram Nallar Chakravarthy, Srilalitha Movva, Jayalakshmi Gosala, Sreenivasu Karra, Uma Devi Komath, Jayaram Chigurupati