Abstract: Described herein are methods and compositions for diagnosing, treating, or ameliorating symptoms of cancer, including Acute Myeloid Leukemia or acute lymphoblastic leukemia, with an inhibitor of SGF29.

Abstract: An alternative milk composition of spirulina digestible, bioavailable proteins, vitamins and minerals is described. The proteins, vitamins and minerals present in spirulina biomass are rendered digestible and bioavailable by unique homogenization process followed by thermo-chemical treatment. The alternative milk made with digestible, bioavailable proteins, vitamins and minerals is formulated with colorant, sweetener, flavor and gelling agent. The milk so obtained is packed with digestible and bioavailable proteins, vitamins and minerals is free from fishy odor and bitter taste.

Abstract: Methods and systems generally include determining coordinated activity in social media movements on a social media channel. The method includes identifying a plurality of markers of coordinated activity through analysis of campaign signals from the social media movements. The plurality of markers includes a network dimension for representing how accounts are connected, a temporal dimension for representing patterns of messages over time, and a semantic dimension for representing a diversity of topics and meanings of the social media movements. The method includes analyzing the campaign signals indicative of the coordinate activity of the social media movements in the social media campaign including determining users within the social media campaign, determining clusters of users that make up the social media campaign and determining relationships between the users participating in the social media movements, and determining propagation patterns across clusters of users of the social media campaign.

Abstract: Methods and systems generally include determining coordinated activity in social media movements on a social media channel. The method includes identifying a plurality of markers of coordinated activity through analysis of campaign signals from the social media movements. The plurality of markers includes a network dimension for representing how accounts are connected, a temporal dimension for representing patterns of messages over time, and a semantic dimension for representing a diversity of topics and meanings of the social media movements. The method includes analyzing the campaign signals indicative of the coordinate activity of the social media movements in the social media campaign including determining users within the social media campaign, determining clusters of users that make up the social media campaign and determining relationships between the users participating in the social media movements, and determining propagation patterns across clusters of users of the social media campaign.

Abstract: Methods of improving physical performance and endurance include administering a capsicum composition to a subject. More particularly the methods include administration of an effective amount of a capsicum composition including capsaicinoids alone and/or in combination with other nutrients for improvement in performance of physical activities. The methods described include administration of a capsicum composition to a subject undergoing physical activity to deliver daily dose of capsaicinoids in an effective amount. The methods include administering a capsicum composition to a subject in an effective amount to reduce blood lipids and oxidative stress. Methods for enhancing physical endurance and exhaustion time include administering an effective amount of a capsicum composition to a physically active subject, wherein body antioxidants are increased and muscle lactates are decreased, resulting in recovery from muscle fatigue arising due to such indoor and/or outdoor physical activities.

Abstract: An aspect described herein includes a method for treating acute myeloid leukemia (AML) in a subject in need thereof comprising, administering to the subject an effective amount of a small molecule tubulin polymerization inhibitor compound. More particularly, another aspect described herein includes a method for treating acute myeloid leukemia in a subject in need thereof comprising, administering to the subject an effective amount of the small molecule tubulin polymerization inhibitor compound described herein in combination with a chemotherapeutic agent.

Abstract: A composition of oily, pungent and odoriferous substances and a process for preparation thereof are described, in particular an extended and sustained release of a stable, free flowing, solid composition of one or more of substances such as capsicum, black pepper, ginger, mustard, cinnamon, garlic, onion, paprika, turmeric and the like, extracts thereof, and/or components thereof, and a process for preparation thereof are described. For example, compositions comprise a substance such as capsicum containing capsaicinoid components, which include for example capsaicin, dihydro-capsaicin, and/or nor-dihydro-capsaicin.

Abstract: An oral dosage form of Spirulina aqueous extract is described here for delivering medications to alleviate symptoms of influenza virus. Most potent antiviral principles of spirulina being polysaccharides with molecular weight ranging from 100-300 kDa, there is need to provide permeation enhancers that help these polysaccharides in crossing the mucus membrane of oropharynx. Apart from enhancing the permeation, the formulation provides sustained effect to ameliorate symptoms of cold, cough, headache, fever related to influenza viral infection.

Abstract: Described herein are compositions comprising a spirulina complex enriched with carotenoids, gamma linolenic acid, zinc and copper. The extract is made highly bioavailable with the addition of suitable bioenhancers, which may also impart additional eye health benefits. The spirulina extract may be used as a dietary supplement or may be added to food or beverage product. Also provided herein is Als provided herein are methods for treating macular degeneration, dry eye syndrome and visual acuity comprising administering the compositions described herein to a patient in need of such treatment.

Abstract: Capsicum compositions are described that include biologically active constituents non-capsaicinoids and capsaicinoids in a specific ratio are useful for the treatment and management of cardiometabolic syndrome and associated risk factors, in a subject in need thereof. The capsicum compositions include a capsicum extract which is prepared by extracting capsicum pods by using suitable polar and non-polar solvents. Capsicum compositions include non-capsaicinoid components like saponins and polyphenols such as flavonoids, which along with capsaicinoids effectively reduce risk factors of cardiometabolic syndrome and also reduce oxidative stress on vital body organs by reducing inflammatory and/or oxidative markers. The capsicum compositions inhibit pancreatic lipase enzyme and enhance lipolysis, when administered in an effective amount to a subject in need thereof. Capsicum compositions as described herein are prepared by human intervention and are safe for consumption.

Abstract: Methods and systems generally include determining coordinated activity in social media movements on a social media channel. The method includes identifying a plurality of markers of coordinated activity through analysis of campaign signals from the social media movements. The plurality of markers includes a network dimension for representing how accounts are connected, a temporal dimension for representing patterns of messages over time, and a semantic dimension for representing a diversity of topics and meanings of the social media movements. The method includes analyzing the campaign signals indicative of the coordinate activity of the social media movements in the social media campaign including determining users within the social media campaign, determining clusters of users that make up the social media campaign and determining relationships between the users participating in the social media movements, and determining propagation patterns across clusters of users of the social media campaign.

Abstract: Carotenoid compositions are described for management, treatment, and/or prevention of stress by reducing cortisol levels and/or improving distribution and/or density of macular pigment and thus improving overall health status. More particularly, a subject in need thereof for the method has disturbed macular pigment optical density or increased levels of cortisol as markers of psychological and physiological stress. Methods are also described of administering macular carotenoid compositions in daily doses of at least or about 0.005 mg/kg body weight of lutein, and at least or about 0.001 mg/kg body weight of meso-zeaxanthin and zeaxanthin isomer along with at least one food grade excipient and evaluating overall health status. The composition may be derived from plant extract containing xanthophylls and/or xanthophylls esters. The composition also reduces cortisol levels in the blood and relieves physiological stress, thus improving overall health status of a subject in need thereof.

Abstract: Compositions are described that include a betacryptoxanthin extract, rich in trans-betacryptoxanthin, which are prepared by a cost and time effective process and are for use in methods of enhancing cardio-respiratory fitness for physical performance and exercise endurance and to maintain healthy lung function. Betacryptoxanthin extract is prepared by a cost and time effective process of saponification and column chromatography, in which saponification cycle time, solvent amount, column separation time and silica amount are reduced, thus making it industrially viable. Betacryptoxanthin compositions increase exercise time, endurance performance, and lung capacity and maintain healthy lung and cardiovascular function during such physical activities. The compositions also improve physical performance, attenuate muscle fatigue, and enhance aerobic respiration utilization capacity.

Abstract: Methods herein are described for improvement in visual function by administering macular carotenoid compositions containing an effective daily dose, to a subject in need thereof. More particularly, methods herein are described and include use of the compositions herein by identifying a subject in need thereof, administering a daily dose of lutein and/or zeaxanthin isomers, comprised of meso-zeaxanthin and R,R zeaxanthin, alone or in combination thereof, the composition also including at least one food grade excipient, and evaluating visual performance. The subject is exposed to light of variable wavelengths and intensity and is suffering from visual fatigue. The composition improves contrast sensitivity, glare performance, photo stress recovery, and/or macular pigment optical density, and thus alleviates visual fatigue. The composition is safe for human and other animals for consumption and can be used for improvement in visual health in the subject, when administered in an effective amount.

Abstract: Beta-cryptoxanthin compositions and methods are described for the management of cardiometabolic syndrome and associated risk factors, in a subject, in need thereof. Methods herein are directed to identifying such subject at risk of developing cardiometabolic syndrome and administering beta-cryptoxanthin composition to assess the condition of an organ. Compositions and methods herein can effectively reduce risk factors of cardiometabolic syndrome, such as hyperlipidemia, insulin resistance, obesity, diabetes, atherosclerosis and/or related cardiovascular disorders. Beta-cryptoxanthin compositions and methods herein can reduce body weight, body fat, glucose levels, and free fatty acids, when administered in effective amounts. The compositions and methods herein can also reduce oxidative stress on organs such as the eye and liver and/or reduce inflammatory and/or oxidative markers, when administered to subjects in need thereof.

Abstract: Methods of improving physical performance and endurance include administering a capsicum composition to a subject. More particularly the methods include administration of an effective amount of a capsicum composition including capsaicinoids alone and/or in combination with other nutrients for improvement in performance of physical activities. The methods described include administration of a capsicum composition to a subject undergoing physical activity to deliver daily dose of capsaicinoids in an effective amount. The methods include administering a capsicum composition to a subject in an effective amount to reduce blood lipids and oxidative stress. Methods for enhancing physical endurance and exhaustion time include administering an effective amount of a capsicum composition to a physically active subject, wherein body antioxidants are increased and muscle lactates are decreased, resulting in recovery from muscle fatigue arising due to such indoor and/or outdoor physical activities.

Abstract: The methods relate to preventing photoreceptor damage caused by blue light by oral administration of a macular carotenoid composition comprising of lutein and zeaxanthin isomers. The photoreceptor damage is prevented through the upregulation of genes and protein synthesis manifested by an increase in the levels gene expression and proteins synthesis of Gnat1, Rhodopsin, NCAM, Rod arrestin, GAP-43, Nrf2, Ho-1 and decrease in the GFAP, NFkB (oxidative stress markers) in rat eye models exposed to visible blue light for various time periods and simultaneously treated with macular carotenoid compositions comprising of lutein zeaxanthin and their isomers. Methods described herein also relate to treatment of visual stress conditions by administering macular carotenoid compositions for treatment headache, blurred vision, photoreceptor degeneration, oxidative stress, endoplasmic reticulum stress and the like, which are caused due to prolonged exposure to blue light source.

Abstract: Curcumin compositions are described for administration to healthy subjects, in need thereof, for improving cardiovascular flow. Curcumin compositions described herein can be administered to a subject in an effective dose of 250 mg to 1000 mg, corresponding to about 50 mg to 200 mg curcuminoids, for improvement of endothelial function and reducing risk of cardiovascular diseases. Compositions herein include curcumin either alone or curcumin along with at least one excipient to enhance absorption. Compositions herein improve endothelial function in healthy subjects having FMD value of 5-7% or higher and who are not diagnosed with cardiovascular disease. Compositions herein also improve cardiovascular endothelial function by reducing vascular resistance and enhancing nitric oxide generation in vascular endothelium.

Abstract: Xanthophyll compositions and their methods of use are described, where the compositions include macular pigments as lutein and/or zeaxanthin isomers, and where they are administered in an effective amount for skin lightening and/or improving overall skin tone and/or health in a subject in need thereof. Methods for treatment are described for improvement and/or protection of skin from effects of light rays of variable intensity and/or wavelength on skin tone and/or skin health. Methods herein include administering a xanthophyll composition for skin lightening and/or improving skin tone and/or overall skin health, and to block the melanin pathway and formation of melanin in melanocytes. The compositions and their administration exhibit increased Individual Typological Angle and minimum erythemal dose, which results in rapid skin lightening.

Abstract: A method for protection, treatment and improvement of liver health includes administering a meso-zeaxanthin composition in an effective amount to a subject in need thereof. In particular, methods are described of administering a meso-zexanthin composition to a subject fed with high fat diet (HFD), and studying the effect of meso-zeaxanthin for treatment of fatty liver condition, through evaluation of various parameters such as biochemical indicators, anti-inflammatory markers, and nutritional markers.