Publication number: 20050222326
Abstract: Functional polyvalent oligomer for applications in medicine and biotechnology are disclosed. These oligomers have the formula (1) wherein R is H, CH3, C2H5, R1, is H, NH2, OH, COOH, X is N-Acetyl Glucosamine mannose, galactose and sialic acid, fructose, ribulose, erythrolose, xylulose, psicose, sorbose, tagatose, glucopyranose, fructose, deoxyribose , galactosamine, sucrose, lactose, isomaltose, maltos, cellobiose, cellulose and amylose, Y is H, COOH, OH or NH2, and n is from 3 to 50. The present invention also relates to synthesis of such oligomeric ligands. The method of synthesis of the present invention for oligomerization can be—applied to other ligands such as sialic acid, mannose and galactose and can—be used for the prevention of infections.
Type:
Application
Filed:
March 30, 2004
Publication date:
October 6, 2005
Inventors:
Mohan Kulkarni, Jayant Khandare
Publication number: 20050096446
Abstract: The present invention relates to tri-block copolymers of molecular weight ranging between 2,000 Daltons to 2,00,000 Daltons having formula (1), having extraordinarily high binding strength, wherein, R1 is H, CH3, C2H5, or C6H5; R2 is H, CH3, C2H5, or C6H5; X is an ester or amide linkage; m is ranging from 3 to 500; n is ranging from 2 to 50; L is OH, NH2, OCH3, or NHCH(CH3)2; Y is N-Acetyl Glucosamine, mannose, galactose, sialic acid, fructose, ribulose, erythrolose, xylulose, psicose, sorbose, tagatose, glucopyranose, fructofuranose, deoxyribose, galactosamine, sucrose, lactose, isomaltose, maltose, cellobiose, cellulose, or amylose, a simple and effective process for the preparation of the tri-block copolymers of formula (1), and a method of preventing and/or treating microbial infections, wherein the said method comprises steps of exposing the microbe to the tri-block copolymer of formula 1, and thereafter, binding of the polymer to the microbe inhibits the microbial infection.
Type:
Application
Filed:
October 29, 2003
Publication date:
May 5, 2005
Applicant:
COUNCIL OF SCIENTIFIC AND INDUSTRIAL
Inventors:
Mohan Kulkarni, Jayant Khandare