Abstract: The invention disclosed relates to a water-soluble composition having enhanced bioavailability useful for the treatment of depression which comprises a synergistic combination of curcumin, at least an antioxidant, a hydrophilic carrier and a fat. The invention also discloses a process for the preparation of the curcumin composition which comprises the steps of dissolving curcumin, at least one antioxidant, a hydrophilic carrier and a fat in a solvent to form a homogenous mass; warming the resultant mass at a temperature ranging from 25° C. to 60° C. for a period of 4 to 8 hours to obtain a dry wet mass; removing the solvent by evaporation to form dry mass and pulverizing the dry mass to form a fine powder.

Abstract: The invention disclosed relates to a water-soluble composition having enhanced bioavailability useful for the treatment of depression which comprises a synergistic combination of curcumin, at least an antioxidant, a hydrophilic carrier and a fat. The invention also discloses a process for the preparation of the curcumin composition which comprises the steps of dissolving curcumin, at least one antioxidant, a hydrophilic carrier and a fat in a solvent to form a homogenous mass; warming the resultant mass at a temperature ranging from 25° C. to 60° C. for a period of 4 to 8 hours to obtain a dry wet mass; removing the solvent by evaporation to form dry mass and pulverizing the dry mass to form a fine powder.

Abstract: A synthetic bulk laxative which comprises a crosslinked graft polymer. It is formed of a hydrophilic monomer partially neutralized up to 75%, a polysaccharide gum up to 3% by weight and a crosslinker up to 2% by weight. The weight percentages are with respect to the hydrophilic monomer. A process for the preparation of the synthetic bulk laxative which comprises up to 75% partial neutralization of a hydrophilic monomer with an alkali. The partially neutralized hydrophilic monomer is polymerized with up to 2% by weight of a cross linker and up to 3% by weight of a polysaccharide gum in the presence of an initiator in an organic solvent under inert atmosphere at 30–80° C. The synthetic bulk laxative is dried at 30–120° C. and pulverized. A formulation of the synthetic bulk laxative in combination with pharmaceutically acceptable excipients.

Abstract: Enteric coated stable oral pharmaceutical composition of acid unstable drug. The enteric coating is a bilayer with a pH gradient across its thickness comprising an inner layer of neutral or near neutral pH 7-7.5 and an outer layer of acidic pH 2-6. Also process for preparng the enteric coated stable oral pharmaceutical composition of acid unstable drug. The enteric coating is first carried out at neutral or near neutral pH of 7-7.5 to form an inner layer of neutral or near neutral pH and then at acidic pH of 2-6 to form an outer layer of acidic pH.