Patents by Inventor Jayaprakash K. Nair

Jayaprakash K. Nair has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • LIPID FORMULATION
    Publication number: 20170143631
    Abstract: The invention features a cationic lipid of formula I, an improved lipid formulation comprising a cationic lipid of formula I and corresponding methods of use. Also disclosed are targeting lipids, and specific lipid formulations comprising such targeting lipids.
    Type: Application
    Filed: June 20, 2016
    Publication date: May 25, 2017
    Applicant: Arbutus Biopharma Corporation
    Inventors: Jianxin Chen, Steven Ansell, Akin Akinc, Joseph Robert Dorkin, Xiaojun Qin, William Cantley, Muthiah Manoharan, Kallanthottathil G. Rajeev, Jayaprakash K. Nair, Muthusamy Jayaraman
  • MONOMERS AND OLIGONUCLEOTIDES COMPRISING CYCLOADDITION ADDUCT(S)
    Publication number: 20170107513
    Abstract: The invention features compounds of formula V or XII: In one embodiment, the invention relates compounds and processes for conjugating ligand to oligonucleotide. The invention further relates to methods for treating various disorders and diseases such as viral infections, bacterial infections, parasitic infections, cancers, allergies, autoimmune diseases, immunodeficiencies and immunosuppression.
    Type: Application
    Filed: December 30, 2016
    Publication date: April 20, 2017
    Inventors: Muthiah MANOHARAN, Jayaprakash K. NAIR, Kallanthottahil G. RAJEEV, Michael E. JUNG
  • Monomers and oligonucleotides comprising cycloaddition adduct(s)
    Patent number: 9566340
    Abstract: The invention features compounds of formula V or XII: In one embodiment, the invention relates compounds and processes for conjugating ligand to oligonucleotide. The invention further relates to methods for treating various disorders and diseases such as viral infections, bacterial infections, parasitic infections, cancers, allergies, autoimmune diseases, immunodeficiencies and immunosuppression.
    Type: Grant
    Filed: October 20, 2015
    Date of Patent: February 14, 2017
    Assignee: Alnylam Pharmaceuticals, Inc.
    Inventors: Muthiah Manoharan, Jayaprakash K. Nair, Kallanthottahil G. Rajeev, Michael E. Jung
  • OLIGONUCLEOTIDE-LIGAND CONJUGATES AND PROCESS FOR THEIR PREPARATION
    Publication number: 20160376585
    Abstract: The present invention relates to ligand conjugates of oligonucleotides (e.g., iRNA agents) and methods for their preparation. The ligands are derived primarily from monosaccharides These conjugates are useful for the in vivo delivery of oligonucleotides.
    Type: Application
    Filed: July 11, 2014
    Publication date: December 29, 2016
    Inventors: Muthiah MANOHARAN, Jayaprakash K. NAIR, Pachamuthu KANDASAMY, Shigeo MATSUDA, Alexander V. KELIN, Muthusamy JAYARAMAN, Kallanthottathil G. RAJEEV
  • BIODEGRADABLE LIPIDS FOR THE DELIVERY OF ACTIVE AGENTS
    Publication number: 20160009637
    Abstract: The present invention relates to a cationic lipid having one or more biodegradable groups located in the mid- or distal section of a lipidic moiety (e.g., a hydrophobic chain) of the cationic lipid. These cationic lipids may be incorporated into a lipid particle for delivering an active agent, such as a nucleic acid. The invention also relates to lipid particles comprising a neutral lipid, a lipid capable of reducing aggregation, a cationic lipid of the present invention, and optionally, a sterol. The lipid particle may further include a therapeutic agent such as a nucleic acid.
    Type: Application
    Filed: March 18, 2015
    Publication date: January 14, 2016
    Inventors: Muthiah MANOHARAN, Martin MAIER, Muthusamy JAYARAMAN, Shigeo MATSUDA, Jayaprakash K. NAIR, Kallanthottathil G. RAJEEV, Akin AKINC, Thomas A. BAILLIE
  • DI-ALIPHATIC SUBSTITUTED PEGYLATED LIPIDS
    Publication number: 20150203446
    Abstract: The disclosure relates to di-aliphatic substituted PEGylated lipids and to methods of their preparation. The disclosure also relates to lipid conjugates containing di-aliphatic substituted PEGylated lipids, and to the use of di-aliphatic substituted PEGylated-lipid conjugates in drug delivery.
    Type: Application
    Filed: September 27, 2012
    Publication date: July 23, 2015
    Inventors: Muthiah Manoharan, Kallanthottathil G. Rajeev, Jayaprakash K. Nair, Muthusamy Jayaraman, Satoru Matsumoto
  • CARBOHYDRATE CONJUGATED RNA AGENTS AND PROCESS FOR THEIR PREPARATION
    Publication number: 20150196655
    Abstract: This disclosure relates to an improved process for the preparation of carbohydrate conjugates. The disclosure also relates to carbohydrate conjugated iRNA agents comprising these carbohydrate conjugates, which have improved purity and are advantageous for the in vivo delivery of the iRNA agents.
    Type: Application
    Filed: August 6, 2013
    Publication date: July 16, 2015
    Inventors: Jayaprakash K. Nair, Alexander V. Kelin, Pachamuthu Kandasamy, Kallanthottahill G. Rajeev, Muthiah Manoharan
  • PEGYLATED LIPIDS AND THEIR USE FOR DRUG DELIVERY
    Publication number: 20140200257
    Abstract: The invention provides poly(ethylene glycol)-lipid conjugates for use in drug delivery.
    Type: Application
    Filed: January 11, 2012
    Publication date: July 17, 2014
    Applicant: ALNYLAM PHARMACEUTICALS, INC.
    Inventors: Kallanthottathil G Rajeev, Muthiah Manoharan, Muthusamy Jayaraman, Martin Maier, Jayaprakash K. Nair, David Butler