Abstract: A method (and structure and computer product) to optimize an operation in a Neural Network Accelerator (NNAccel) that includes a hierarchy of neural network layers as computational stages for the NNAccel and a configurable hierarchy of memory modules including one or more on-chip Static Random-Access Memory (SRAM) modules and one or more Dynamic Random-Access Memory (DRAM) modules, where each memory module is controlled by a plurality of operational parameters that are adjustable by a controller of the NNAcc. The method includes detecting bit error rates of memory modules currently being used by the NNAccel and determining, by the controller, whether the detected bit error rates are sufficient for a predetermined threshold value for an accuracy of a processing of the NNAccel. One or more operational parameters of one or more memory modules are dynamically changed by the controller to move to a higher accuracy state when the accuracy is below the predetermined threshold value.

Abstract: Methods, systems, and techniques for data compression. A cluster fingerprint of an uncompressed data block is determined to correspond to a cluster fingerprint of a base block stored in a base array. This determining involves looking up the cluster fingerprint of the first base block from the base array using the cluster fingerprint of the first uncompressed data block. The difference between the uncompressed data block and the base block is determined, and a compressed data block is encoded using this difference. The compressed data block is then stored in a data array.

Abstract: The disclosure relates to double stranded ribonucleic acid (dsRNAi) agents and compositions targeting the APP gene, as well as methods of inhibiting expression of an APP gene and methods of treating subjects having an APP-associated disease or disorder, such as cerebral amyloid angiopathy (CAA) and early onset familial Alzheimer disease (EOFAD or eFAD), using such dsRNAi agents and compositions.

Abstract: Methods, systems, and techniques for data compression. A cluster fingerprint of an uncompressed data block is determined to correspond to a cluster fingerprint of a base block stored in a base array. This determining involves looking up the cluster fingerprint of the first base block from the base array using the cluster fingerprint of the first uncompressed data block. The difference between the uncompressed data block and the base block is determined, and a compressed data block is encoded using this difference. The compressed data block is then stored in a data array.

Abstract: The present invention provides a phosphorothioate-modified oligonucleotide comprising a structure shown below: The present invention also provides a phosphorothioate-modified oligonucleotide comprising a structure having formula (CIII):

Abstract: Single error correction (“SEC”) code and triple error detection (“TED”) code are used to optimize bandwidth and resilience under multiple bit failures. One or more errors in data stored in duplicated registers are detected and corrected using the SEC code and TED code where simultaneous read operations are produced with two copies of data for each of the duplicated registers for a multi-port banked memory array. The SEC code and TED code may be included in each of the two data copies of the simultaneous read operations.

Abstract: The disclosure relates to double stranded ribonucleic acid (dsRNAi) agents and compositions targeting the APP gene, as well as methods of inhibiting expression of an APP gene and methods of treating subjects having an APP-associated disease or disorder, such as cerebral amyloid angiopathy (CAA) and early onset familial Alzheimer disease (EOFAD or eFAD), using such dsRNAi agents and compositions.

Abstract: Various embodiments are provided for enhanced error correction using single error correction (“SEC”) code and triple error detection (“TED”) code to optimize bandwidth and resilience under multiple bit failures by a processor. One or more errors may be detected and corrected in duplicated registers using an SEC code and TED code where simultaneous read operations are produced with two copies of data for each of the duplicated registers for a multi-port banked memory array. The SEC code and TED code may be included in each of the two data copies of the simultaneous read operations.

Abstract: Systems, methods and computer program products using multi-tag storage to enable efficient data compression in caches without increasing a tag/data area overhead. One method can comprise storing compressed versions of data elements in a data array of a cache, with tags for the compressed versions respectively appended to the compressed versions as stored in the data array, and storing hashed versions of the tags in a tag array of the cache, wherein the hashed versions of the tags respectively have fewer bits than the tags. A tag block may store hashed versions of tags corresponding to first and second compressed data elements stored in a cacheline of the cache. Hashed tag entries may be compared with full versions of the tags appended to compressed versions of data elements stored in the data array to prevent false positive cache reads. A compressed identifier (CID) may be stored with the hashed versions of tags in the tag array.

Abstract: The disclosure relates to double stranded ribonucleic acid (dsRNAi) agents and compositions targeting the APP gene, as well as methods of inhibiting expression of an APP gene and methods of treating subjects having an APP-associated disease or disorder, such as cerebral amyloid angiopathy (CAA) and early onset familial Alzheimer disease (EOFAD or eFAD), using such dsRNAi agents and compositions.

Abstract: A method (and structure and computer product) to optimize an operation in a Neural Network Accelerator (NNAccel) that includes a hierarchy of neural network layers as computational stages for the NNAccel and a configurable hierarchy of memory modules including one or more on-chip Static Random-Access Memory (SRAM) modules and one or more Dynamic Random-Access Memory (DRAM) modules, where each memory module is controlled by a plurality of operational parameters that are adjustable by a controller of the NNAcc. The method includes detecting bit error rates of memory modules currently being used by the NNAccel and determining, by the controller, whether the detected bit error rates are sufficient for a predetermined threshold value for an accuracy of a processing of the NNAccel. One or more operational parameters of one or more memory modules are dynamically changed by the controller to move to a higher accuracy state when the accuracy is below the predetermined threshold value.

Abstract: The present invention provides a phosphorothioate-modified oligonucleotide comprising a structure shown below: The present invention also provides a phosphorothioate-modified oligonucleotide comprising a structure having formula (CIII):

Abstract: The present invention provides a phosphorothioate-modified oligonucleotide comprising a structure shown below: The present invention also provides a phosphorothioate-modified oligonucleotide comprising a structure having formula (CIII):

Abstract: Assays, methods, reagents and kits for evaluating the level of an antibody against a nucleic acid molecule, e.g., a double-stranded oligonucleotide or RNA molecule (e.g., dsRNA), are disclosed herein.

Abstract: Systems, methods and computer program products using multi-tag storage to enable efficient data compression in caches without increasing a tag/data area overhead. One method can comprise storing compressed versions of data elements in a data array of a cache, with tags for the compressed versions respectively appended to the compressed versions as stored in the data array, and storing hashed versions of the tags in a tag array of the cache, wherein the hashed versions of the tags respectively have fewer bits than the tags. A tag block may store hashed versions of tags corresponding to first and second compressed data elements stored in a cacheline of the cache. Hashed tag entries may be compared with full versions of the tags appended to compressed versions of data elements stored in the data array to prevent false positive cache reads. A compressed identifier (CID) may be stored with the hashed versions of tags in the tag array.

Abstract: A computer monitors a memory system during operation. The computer detects a first number of errors in the memory system. The computer determines that the first number of errors is below an error level threshold. The computer lowers a first group of one or more memory parameters of the memory system by a first amount. After the lowering of one or more memory parameters by the first amount, the computer detects a second number of errors in the memory system. The computer determines that the second number of errors is above the error level threshold. The computer raises a second group of one or more memory parameters of the memory system by a second amount.

Abstract: Embodiments include techniques for receiving a cacheline of data, hashing the cacheline into a plurality of chunks, wherein each chunk includes a pattern of bits, storing the plurality of chunks in a pattern table, wherein the plurality of chunks are indexed in the pattern table based on the pattern of bits of each chunk, and identifying a repeated pattern of bits of the plurality of chunks and selecting the repeated pattern of bits as candidate pattern. Techniques include comparing a threshold number of bits of the candidate pattern to the pattern of bits of the plurality of chunks in the pattern table; based on the comparison, inserting valid bits and a tag into the pattern table for the candidate pattern by replacing bits in the candidate pattern, and writing the candidate pattern, including the valid bits and the tag, into a location of the memory corresponding to the candidate pattern.

Abstract: The present invention provides a phosphorothioate-modified oligonucleotide comprising a structure shown below: The present invention also provides a phosphorothioate-modified oligonucleotide comprising a structure having formula (CIII):

Abstract: Embodiments include techniques for receiving a cacheline of data, hashing the cacheline into a plurality of chunks, wherein each chunk includes a pattern of bits, storing the plurality of chunks in a pattern table, wherein the plurality of chunks are indexed in the pattern table based on the pattern of bits of each chunk, and identifying a repeated pattern of bits of the plurality of chunks and selecting the repeated pattern of bits as candidate pattern. Techniques include comparing a threshold number of bits of the candidate pattern to the pattern of bits of the plurality of chunks in the pattern table; based on the comparison, inserting valid bits and a tag into the pattern table for the candidate pattern by replacing bits in the candidate pattern, and writing the candidate pattern, including the valid bits and the tag, into a location of the memory corresponding to the candidate pattern.

Abstract: A computer monitors a memory system during operation. The computer detects a first number of errors in the memory system. The computer determines that the first number of errors is below an error level threshold. The computer lowers a first group of one or more memory parameters of the memory system by a first amount. After the lowering of one or more memory parameters by the first amount, the computer detects a second number of errors in the memory system. The computer determines that the second number of errors is above the error level threshold. The computer raises a second group of one or more memory parameters of the memory system by a second amount.