Patents by Inventor Jayaraman Kannapan

Jayaraman Kannapan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROCESSES FOR MAKING PONATINIB AND INTERMEDIATES THEREOF
    Publication number: 20160362411
    Abstract: Methods are disclosed for making 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]benzamide, intermediates and pharmaceutically acceptable salts thereof.
    Type: Application
    Filed: June 10, 2016
    Publication date: December 15, 2016
    Inventors: Ravishanker Kovi, Jayaraman Kannapan, Sanjay F. Thakor, Ashish Naik, Dhakhada Chetana Bharatbhai, Khichi Kuldip Fatehlal, Shivnath Sahebrao Patil
  • METHODS OF MAKING CARFILZOMIB AND INTERMEDIATES THEREOF
    Publication number: 20160340388
    Abstract: Racemization-free methods are disclosed for the synthesis of carfilzomib. Novel intermediates and methods of making carfilzomib employing fragment condensation using the novel intermediates are disclosed. Amorphous carfilzomib and methods of making same are disclosed.
    Type: Application
    Filed: August 4, 2016
    Publication date: November 24, 2016
    Applicant: Apicore US LLC
    Inventors: Ravishanker Kovi, Jayaraman Kannapan, Vasanthakumar G Ramu, Alaparthi Lakshmi Prasad, Talluri Bhushaiah Chowdary, Gaurav Kulkarni, Saiyed Akeel Ahmed Shakeel Ahmed, Veerabhadra Rao Bobbili, N V Raghavalu Dusanapudi, Anand V. Mantri
  • Processes for making ponatinib and intermediates thereof
    Patent number: 9493473
    Abstract: Novel synthetic approaches to make 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]benzamide, intermediates and pharmaceutically acceptable salts thereof are provided.
    Type: Grant
    Filed: December 30, 2015
    Date of Patent: November 15, 2016
    Assignee: Apicore US LLC
    Inventors: Ravishanker Kovi, Jayaraman Kannapan, Sanjay F. Thakor, Rajesh A Patel
  • PROCESS OF MAKING REGADENOSON AND NOVEL POLYMORPH THEREOF
    Publication number: 20160244474
    Abstract: Novel processes for making the N-pyrrazole substituted 2-adenosine derivative regadenoson and a novel polymorph thereof. The novel polymorph of regadenoson designated form H and drug substances and pharmaceutical compositions including the novel polymorph H are disclosed.
    Type: Application
    Filed: February 2, 2016
    Publication date: August 25, 2016
    Applicant: Apicore US LLC
    Inventors: Ravishanker Kovi, Ashish Naik, Piyush Fadadu, Jayaraman Kannapan
  • METHODS OF MAKING CARFILZOMIB AND INTERMEDIATES THEREOF
    Publication number: 20160115198
    Abstract: Racemization-free methods are disclosed for the synthesis of carfilzomib. Novel intermediates and methods of making carfilzomib employing fragment condensation using the novel intermediates are disclosed. Amorphous carfilzomib and methods of making same are disclosed.
    Type: Application
    Filed: October 26, 2015
    Publication date: April 28, 2016
    Inventors: Ravishanker Kovi, Jayaraman Kannapan, Vasanthakumar G Ramu, Alaparthi Lakshmi Prasad, Talluri Bhushaiah Chowdary, Gaurav Kulkarni, Saiyed Akeel Ahmed Shakeel Ahmed, Veerabhadra Rao Bobbili, N V Raghavalu Dusanapudi, Anand V. Mantri
  • PROCESSES FOR MAKING PONATINIB AND INTERMEDIATES THEREOF
    Publication number: 20160108053
    Abstract: Novel synthetic approaches to make 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]benzamide, intermediates and pharmaceutically acceptable salts thereof are provided.
    Type: Application
    Filed: December 30, 2015
    Publication date: April 21, 2016
    Applicant: Apicore US LLC
    Inventors: Ravishanker Kovi, Jayaraman Kannapan, Sanjay F. Thakor, Rajesh A. Patel
  • METHODS OF MAKING NETUPITANT AND INTERMEDIATES THEREOF
    Publication number: 20150315149
    Abstract: Methods are disclosed for the preparation of netupitant and pharmaceutically acceptable salts thereof which are novel, easily reproducible, environmentally safe and cost effective. The methods may employ inexpensive starting materials and the preparation processes for intermediates are simple and highly reproducible. Novel intermediates for the preparation of netupitant and pharmaceutically acceptable salts thereof are also disclosed. Amorphous netupitant and methods of making same are disclosed.
    Type: Application
    Filed: May 4, 2015
    Publication date: November 5, 2015
    Inventors: Ravishanker Kovi, Jayaraman Kannapan, Sanjay F. Thakor, Ashish Naik
  • Process for preparing saxagliptin and its novel intermediates useful in the synthesis thereof
    Patent number: 9150511
    Abstract: Methods of making saxagliptin, pharmaceutically acceptable salts and hydrates thereof and intermediates thereof.
    Type: Grant
    Filed: April 29, 2014
    Date of Patent: October 6, 2015
    Assignee: Apicore US LLC
    Inventors: Ravishanker Kovi, KeshavRao Rapole, Ashish Naik, Jayaraman Kannapan, Muralikrishna Madala, Sanjay Thakor
  • PROCESSES FOR MAKING PONATINIB AND INTERMEDIATES THEREOF
    Publication number: 20140343282
    Abstract: Novel synthetic approaches to make 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]benzamide, intermediates and pharmaceutically acceptable salts thereof are provided.
    Type: Application
    Filed: May 16, 2014
    Publication date: November 20, 2014
    Applicant: Apicore, LLC
    Inventors: Ravishanker Kovi, Jayaraman Kannapan, Sanjay F. Thakor, Rajesh A Patel
  • PROCESS FOR PREPARING SAXAGLIPTIN AND ITS NOVEL INTERMEDIATES USEFUL IN THE SYNTHESIS THEREOF
    Publication number: 20140235870
    Abstract: Methods of making saxagliptin, pharmaceutically acceptable salts and hydrates thereof and intermediates thereof.
    Type: Application
    Filed: April 29, 2014
    Publication date: August 21, 2014
    Applicant: Apicore, LLC
    Inventors: Ravishanker Kovi, KeshavRao Rapole, Ashish Naik, Jayaraman Kannapan, Muralikrishna Madala, Sanjay Thakor
  • Process for preparing saxagliptin and its novel intermediates useful in the synthesis thereof
    Patent number: 8748631
    Abstract: Methods of making saxagliptin, pharmaceutically acceptable salts and hydrates thereof and intermediates thereof.
    Type: Grant
    Filed: May 24, 2012
    Date of Patent: June 10, 2014
    Assignee: Apicore, LLC
    Inventors: Ravishanker Kovi, KeshavRao Rapole, Ashish Naik, Jayaraman Kannapan, Murali Krishna Madala, Sanjay F. Thakor
  • CIS-2-METHYLSPIRO 1, 3-OXATHIOLANE 5-3 QUINUCLIDINE
    Publication number: 20130237707
    Abstract: Pharmaceutical-grade compounds containing cis-2-methylspiro(1,3-oxathiolane-5,3?)quinuclidine having a purity >99.0% by HPLC with less than 0.5% of trans-2-methylspiro(1,3-oxathiolane-5,3?)quinuclidine are provided.
    Type: Application
    Filed: April 30, 2013
    Publication date: September 12, 2013
    Applicant: Apicore, LLC
    Inventors: Ravishanker Kovi, Jayaraman Kannapan, Talluri Buhshaiah Chowdari, Chirag Vasantlal Shah
  • Process for the preparation of cis-2-methylspiro (1,3-oxathiolane 5-3?) quinuclidine
    Patent number: 8450487
    Abstract: Methods are provided for making pharmaceutical-grade cis-2-methylspiro(1,3-oxathiolane-5,3?)quinuclidine and pharmaceutically acceptable salts thereof by isomerizing racemic 2-methylspiro(1,3-oxathiolane-5,3?)quinuclidine to cis-2-methylspiro(1,3-oxathiolane-5,3?)quinuclidine and subsequent purification of the C-MSOQ by salt formation with inexpensive and commercially available material such as sulfuric acid. Purification methods are disclosed which employ an organic solvent/water system and recrystallization with an organic solvent such as acetone.
    Type: Grant
    Filed: June 8, 2010
    Date of Patent: May 28, 2013
    Assignee: Apicore, LLC
    Inventors: Ravishanker Kovi, Jayaraman Kannapan, Talluri Buhshaiah Chowdari, Chirag Vasantlal Shah
  • PROCESS FOR PREPARING SAXAGLIPTIN AND ITS NOVEL INTERMEDIATES USEFUL IN THE SYNTHESIS THEREOF
    Publication number: 20130023671
    Abstract: Methods of making saxagliptin, pharmaceutically acceptable salts and hydrates thereof and intermediates thereof.
    Type: Application
    Filed: May 24, 2012
    Publication date: January 24, 2013
    Applicant: APICORE, LLC
    Inventors: Ravishanker Kovi, KeshavRao Rapole, Ashish Naik, Jayaraman Kannapan, Murali Krishna Madala, Sanjay F. Thakor
  • PROCESS FOR THE PREPARATION OF CIS-2-METHYLSPIRO (1, 3-OXATHIOLANE 5-3') QUINUCLIDINE
    Publication number: 20110301352
    Abstract: Methods are provided for making pharmaceutical-grade cis-2-methylspiro(1,3-oxathiolane-5,3?)quinuclidine and pharmaceutically acceptable salts thereof by isomerizing racemic 2-methylspiro(1,3-oxathiolane-5,3?)quinuclidine to cis-2-methylspiro(1,3-oxathiolane-5,3?)quinuclidine and subsequent purification of the C-MSOQ by salt formation with inexpensive and commercially available material such as sulfuric acid. Purification methods are disclosed which employ an organic solvent/water system and recrystallization with an organic solvent such as acetone.
    Type: Application
    Filed: June 8, 2010
    Publication date: December 8, 2011
    Applicant: APICORE, LLC
    Inventors: Ravishanker Kovi, Jayaraman Kannapan, Talluri Buhshaiah Chowdari, Chirag Vasantlal Shah