Patents by Inventor Jaydeep Roy
Jaydeep Roy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10934519Abstract: The methods of harvesting cells are provided, wherein the methods comprise introducing a processing material and a source material into a processing loop. The processing loop comprises a processing chamber and a filtering device. The processing material and the source material are circulating through the processing chamber and the filtering device, wherein the processing chamber has a mass; balancing an influx of the processing material into the processing chamber with a permeate flux of the filtering device to maintain the mass of the processing chamber at a constant value; and collecting the cells in a collection chamber. Cell harvesting devices are also provided for processing and harvesting cells using a control law to balance the mass of the processing chamber through the entire process.Type: GrantFiled: July 29, 2011Date of Patent: March 2, 2021Assignee: Global Life Sciences Solutions USA LLCInventors: Jaydeep Roy, Andrew Michael Leach, Weston Blaine Griffin, Stefan Rakuff, Philip Alexander Shoemaker
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Patent number: 10088399Abstract: A high-throughput system for processing biological material that comprises: a tray that supports a functionally-closed fluid path subsystem comprising, a vessel for containing and enabling the biological material to separate into two or more distinct submaterials; one or more receptacles to receive one or more of the submaterials from the vessel; a filtration device; a conduit through which one or more submaterials are transported between at least the vessel and the filtration device; and a first engagement structure; a processing unit comprising, a pumping device for moving one or more of the submaterials between at least the vessel and the filtration device via the conduit; a second engagement structure corresponding to the first engagement structure; a locking mechanism for at least temporarily holding the tray in a fixed position relative to the processing unit; a control device that automatically starts and stops the pumping device in response to one or more commands.Type: GrantFiled: May 1, 2015Date of Patent: October 2, 2018Assignee: GENERAL ELECTRIC COMPANYInventors: Weston Blaine Griffin, Jaydeep Roy, Phillip Alexander Shoemaker, William Patrick Waters
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Patent number: 9347033Abstract: A method of processing an adipose tissue to collect adipose derived regenerative cells is provided, wherein the method comprises providing a vessel comprising a fluid jet mixer, introducing the adipose tissue into the vessel, introducing a buffer solution into the vessel; washing the adipose tissue using the fluid jet mixer; introducing an enzyme solution into the vessel; initiating jet mixing into the vessel comprising the adipose tissue, the enzyme solution, and the buffer solution using the fluid jet mixer to digest the adipose tissue to form a digestion product; phase-separating the digestion product into a digested buoyant fat layer and a non-buoyant aqueous layer; and collecting the non-buoyant aqueous layer comprising the adipose derived regenerative cells. A system of processing an adipose tissue to collect adipose derived regenerative cells is also provided.Type: GrantFiled: July 30, 2015Date of Patent: May 24, 2016Assignee: General Electric CompanyInventors: Zaeem Ashraf Khan, Aaron Joseph Dulgar-Tulloch, Stefan Rakuff, Philip Alexander Shoemaker, Erik Leeming Kvam, Xiaohui Chen, Jaydeep Roy
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Publication number: 20150337263Abstract: A method of processing an adipose tissue to collect adipose derived regenerative cells is provided, wherein the method comprises providing a vessel comprising a fluid jet mixer, introducing the adipose tissue into the vessel, introducing a buffer solution into the vessel; washing the adipose tissue using the fluid jet mixer; introducing an enzyme solution into the vessel; initiating jet mixing into the vessel comprising the adipose tissue, the enzyme solution, and the buffer solution using the fluid jet mixer to digest the adipose tissue to form a digestion product; phase-separating the digestion product into a digested buoyant fat layer and a non-buoyant aqueous layer; and collecting the non-buoyant aqueous layer comprising the adipose derived regenerative cells. A system of processing an adipose tissue to collect adipose derived regenerative cells is also provided.Type: ApplicationFiled: July 30, 2015Publication date: November 26, 2015Inventors: Zaeem Ashraf Khan, Aaron Joseph Dulgar-Tulloch, Stefan Rakuff, Philip Alexander Shoemaker, Erik Leeming Kvam, Xiaohui Chen, Jaydeep Roy
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Publication number: 20150233803Abstract: A high-throughput system for processing biological material that comprises: a tray that supports a functionally-closed fluid path subsystem comprising, a vessel for containing and enabling the biological material to separate into two or more distinct submaterials; one or more receptacles to receive one or more of the submaterials from the vessel; a filtration device; a conduit through which one or more submaterials are transported between at least the vessel and the filtration device; and a first engagement structure; a processing unit comprising, a pumping device for moving one or more of the submaterials between at least the vessel and the filtration device via the conduit; a second engagement structure corresponding to the first engagement structure; a locking mechanism for at least temporarily holding the tray in a fixed position relative to the processing unit; a control device that automatically starts and stops the pumping device in response to one or more commands.Type: ApplicationFiled: May 1, 2015Publication date: August 20, 2015Inventors: Weston Blaine Griffin, Jaydeep Roy, Phillip Alexander Shoemaker, William Patrick Waters
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Patent number: 9109198Abstract: A method of processing an adipose tissue to collect adipose derived regenerative cells is provided, wherein the method comprises providing a vessel comprising a fluid jet mixer; introducing the adipose tissue into the vessel; introducing a buffer solution into the vessel; washing the adipose tissue using the fluid jet mixer; introducing an enzyme solution into the vessel; initiating jet mixing into the vessel comprising the adipose tissue, the enzyme solution, and the buffer solution using the fluid jet mixer to digest the adipose tissue to form a digestion product; phase-separating the digestion product into a digested buoyant fat layer and a non-buoyant aqueous layer; and collecting the non-buoyant aqueous layer comprising the adipose derived regenerative cells. A system of processing an adipose tissue to collect adipose derived regenerative cells is also provided.Type: GrantFiled: April 29, 2011Date of Patent: August 18, 2015Assignee: General Electric CompanyInventors: Zaeem Ashraf Khan, Aaron Joseph Dulgar-Tulloch, Stefan Rakuff, Philip Alexander Shoemaker, Erik Leeming Kvam, Xiaohui Chen, Jaydeep Roy
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Publication number: 20150169811Abstract: A method implemented using at least one processor includes receiving a plurality of measured operational parameters of a turbo machine having a rotor and a stator. The plurality of measured operational parameters includes a plurality of real-time operational parameters and a plurality of stored operational parameters. The method further includes generating a finite element model of the turbo machine and generating a plurality of snapshots based on the finite element model and the plurality of stored operational parameters. The method further includes generating a reduced order model based on the plurality of snapshots. The method also includes determining an estimated clearance between the rotor and the stator during operation of the turbo machine, based on the reduced order model and the plurality of real-time operational parameters.Type: ApplicationFiled: December 18, 2013Publication date: June 18, 2015Applicant: General Electric CompanyInventors: Norman Arnold Turnquist, Changjie Sun, Deepak Trivedi, Jaydeep Roy, Emad Andarawis Andarawis, Murat Inalpolat, Arun Karthi Subramaniyan, Fernando Javier D'Amato, Emrah Biyik
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Patent number: 9034280Abstract: A high-throughput system for processing biological material that comprises: a tray that supports a functionally-closed fluid path subsystem comprising, a vessel for containing and enabling the biological material to separate into two or more distinct submaterials; one or more receptacles to receive one or more of the submaterials from the vessel; a filtration device; a conduit through which one or more submaterials are transported between at least the vessel and the filtration device; and a first engagement structure; a processing unit comprising, a pumping device for moving one or more of the submaterials between at least the vessel and the filtration device via the conduit; a second engagement structure corresponding to the first engagement structure; a locking mechanism for at least temporarily holding the tray in a fixed position relative to the processing unit; a control device that automatically starts and stops the pumping device in response to one or more commands.Type: GrantFiled: December 16, 2009Date of Patent: May 19, 2015Assignee: GENERAL ELECTRIC CORPORATIONInventors: Weston Blaine Griffin, Jaydeep Roy, Phillip Alexander Shoemaker, William Patrick Waters
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Patent number: 8512566Abstract: Disclosed herein is a disposable fluid path for processing complex materials. The disposable fluid path comprises a gravity assisted disposable system for separating a biological sample into two or more distinct submaterials through sedimentation. The fluid path is comprised of a sample delivery conduit and bag-set wherein the bag set comprising a tubing assembly, a separation assembly, and a filter assembly. Methods of using the system are also disclosed.Type: GrantFiled: December 11, 2009Date of Patent: August 20, 2013Assignee: General Electric CompanyInventors: Weston Blaine Griffin, Jaydeep Roy, Eric Douglas Williams, Philip Alexander Shoemaker, James Mitchell White
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Publication number: 20130029411Abstract: The methods of harvesting cells are provided, wherein the methods comprise introducing a processing material and a source material into a processing loop. The processing loop comprises a processing chamber and a filtering device. The processing material and the source material are circulating through the processing chamber and the filtering device, wherein the processing chamber has a mass; balancing an influx of the processing material into the processing chamber with a permeate flux of the filtering device to maintain the mass of the processing chamber at a constant value; and collecting the cells in a collection chamber. Cell harvesting devices are also provided for processing and harvesting cells using a control law to balance the mass of the processing chamber through the entire process.Type: ApplicationFiled: July 29, 2011Publication date: January 31, 2013Applicant: GENERAL ELECTRIC COMPANYInventors: Jaydeep Roy, Andrew Michael Leach, Weston Blaine Griffin, Stefan Rakuff, Philip Alexander Shoemaker
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Publication number: 20120276628Abstract: A method of processing an adipose tissue to collect adipose derived regenerative cells is provided, wherein the method comprises providing a vessel comprising a fluid jet mixer; introducing the adipose tissue into the vessel; introducing a buffer solution into the vessel; washing the adipose tissue using the fluid jet mixer; introducing an enzyme solution into the vessel; initiating jet mixing into the vessel comprising the adipose tissue, the enzyme solution, and the buffer solution using the fluid jet mixer to digest the adipose tissue to form a digestion product; phase-separating the digestion product into a digested buoyant fat layer and a non-buoyant aqueous layer; and collecting the non-buoyant aqueous layer comprising the adipose derived regenerative cells. A system of processing an adipose tissue to collect adipose derived regenerative cells is also provided.Type: ApplicationFiled: April 29, 2011Publication date: November 1, 2012Applicant: GENERAL ELECTRIC COMPANYInventors: Zaeem Ashraf Khan, Aaron Joseph Dulgar-Tulloch, Stefan Rakuff, Philip Alexander Shoemaker, Erik Leeming Kvam, Xiaohui Chen, Jaydeep Roy
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Publication number: 20110143427Abstract: A high-throughput system for processing biological material that comprises: a tray that supports a functionally-closed fluid path subsystem comprising, a vessel for containing and enabling the biological material to separate into two or more distinct submaterials; one or more receptacles to receive one or more of the submaterials from the vessel; a filtration device; a conduit through which one or more submaterials are transported between at least the vessel and the filtration device; and a first engagement structure; a processing unit comprising, a pumping device for moving one or more of the submaterials between at least the vessel and the filtration device via the conduit; a second engagement structure corresponding to the first engagement structure; a locking mechanism for at least temporarily holding the tray in a fixed position relative to the processing unit; a control device that automatically starts and stops the pumping device in response to one or more commands.Type: ApplicationFiled: December 16, 2009Publication date: June 16, 2011Applicant: GENERAL ELECTRIC COMPANYInventors: Weston Blaine Griffin, Jaydeep Roy, Phillip Alexander Shoemaker, William Patrick Waters
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Publication number: 20110139723Abstract: Disclosed herein is a disposable fluid path for processing complex materials. The disposable fluid path comprises a gravity assisted disposable system for separating a biological sample into two or more distinct submaterials through sedimentation. The fluid path is comprised of a sample delivery conduit and bag-set wherein the bag set comprising a tubing assembly, a separation assembly, and a filter assembly. Methods of using the system are also disclosed.Type: ApplicationFiled: December 11, 2009Publication date: June 16, 2011Applicant: GENERAL ELECTRIC COMPANYInventors: Weston Blaine Griffin, Jaydeep Roy, Eric Douglas Williams, Philip Alexander Shoemaker, James Mitchell White
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Patent number: 7633290Abstract: Provided is an apparatus and method for automated hyperpolarization of samples for use as an imaging agent comprising a sample box, an airlock chamber configured to receive a sample from the sample box, a cryogenic chamber, a guide channel to transport samples from the airlock chamber to the cryogenic chamber, a heater and pressure module coupled to the sample box, an insertion and retraction device to transport samples through the guide channel to and from the cryogenic chamber, a dissolution module coupled to the sample box, and a controller to regulate hyperpolarization of the samples by controlling one or more of position, sequencing, temperature, pressure, and dissolution of the samples within the apparatus. Also provided is a machine-readable medium comprising instruction which, when executed by a controller, causes a hyperpolarization apparatus to perform the steps of hyperpolarization of a sample.Type: GrantFiled: September 9, 2008Date of Patent: December 15, 2009Assignee: General Electric CompanyInventors: Abdul Rahman Abdallah Al-khalidy, Bruce Campbell Amm, John Arthur Urbahn, Jan Henrik Ardenkjaer-Larsen, Vincent Paul Staudinger, Jaydeep Roy