Patents by Inventor Jayesh Chhotubhai Patel

Jayesh Chhotubhai Patel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Assay for assessing conformational stability of membrane protein
    Patent number: 10458993
    Abstract: The invention provides an assay for assessing the conformational stability of a membrane protein, comprising: (a) providing a sample comprising a first population and a second population of a membrane protein; wherein the membrane protein in the first population is labelled with a donor label and the membrane protein in the second population is labelled with an acceptor label, or the membrane protein in the first population is labelled with an acceptor label and the membrane protein in the second population is labelled with a donor label, (b) exposing the first and second populations of the membrane protein to a stability modulating agent and/or condition, (c) and assessing aggregation between membrane proteins of the first and second populations by activating the donor label to permit a distance-dependent interaction with the acceptor label, which interaction produces a detectable signal.
    Type: Grant
    Filed: May 31, 2013
    Date of Patent: October 29, 2019
    Assignee: Heptares Therapeutics Limited
    Inventors: Fiona Hamilton Marshall, Seyed Ali Jazayeri-Dezfuly, Jayesh Chhotubhai Patel
  • ASSAYS
    Publication number: 20150147822
    Abstract: The invention provides an assay for assessing the conformational stability of a membrane protein, comprising: (a) providing a sample comprising a first population and a second population of a membrane protein; wherein the membrane protein in the first population is labelled with a donor label and the membrane protein in the second population is labelled with an acceptor label, or the membrane protein in the first population is labelled with an acceptor label and the membrane protein in the second population is labelled with a donor label, (b) exposing the first and second populations of the membrane protein to a stability modulating agent and/or condition, (c) and assessing aggregation between membrane proteins of the first and second populations by activating the donor label to permit a distance-dependent interaction with the acceptor label, which interaction produces a detectable signal.
    Type: Application
    Filed: May 31, 2013
    Publication date: May 28, 2015
    Applicant: Heptares Therapeutics Limited
    Inventors: Fiona Hamilton Marshall, Seyed Ali Jazayeri-Dezfuly, Jayesh Chhotubhai Patel