Patents by Inventor Jayhong Chong

Jayhong Chong has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MODULATORS OF SPERM HYPERMOTILITY AND USES THEREOF
    Publication number: 20150335622
    Abstract: The invention provides novel compositions and compounds that inhibit CatSper channel activity, that preferentially inhibits sperm hyperactivity over sperm motility, or both. The compounds of the invention are useful as contraceptive agents that may be adminstered to males, females, or concurrently to both sexual partners. The invention further provides methods of conducting drug discovery business and of conducting a reproductive medicine business. The invention also provides methods of identifying compounds that modulate sperm hypermotility.
    Type: Application
    Filed: December 22, 2014
    Publication date: November 26, 2015
    Applicant: HYDRA BIOSCIENCES, INC.
    Inventors: Jayhong A. Chong, Magdalene M. Moran
  • Compounds of modulating TRPV3 function
    Patent number: 9181219
    Abstract: The present application relates to compounds and methods for treating pain and other conditions related to TRPV3.
    Type: Grant
    Filed: January 29, 2013
    Date of Patent: November 10, 2015
    Assignee: HYDRA BIOSCIENCES, INC.
    Inventors: Magdalene M. Moran, Jayhong A. Chong, Christopher Fanger, Amy S. Ripka, Glenn R. Larsen, Xiaoguang Zhen, Dennis John Underwood, Manfred Weigele
  • COMPOUNDS FOR MODULATING TRPV3 FUNCTION
    Publication number: 20150299225
    Abstract: The present application relates to compounds and methods for treating pain and other conditions related to TRPV3.
    Type: Application
    Filed: November 14, 2014
    Publication date: October 22, 2015
    Applicant: HYDRA BIOSCIENCES, INC.
    Inventors: Jayhong A. Chong, Christopher Fanger, Glenn R. Larsen, William C. Lumma, JR., Magdalene M. Moran, Amy Ripka, Dennis John Underwood, Manfred Weigele, Xiaoguang Zhen, Anu Mahadevan, Peter Meltzer
  • Methods and compositions for treating anxiety
    Patent number: 9139573
    Abstract: Methods of treating a TRPC5 mediated disorder in a subject by administering an effective amount of a TRPC5 antagonist, such as a compound disclosed herein, are described.
    Type: Grant
    Filed: December 10, 2013
    Date of Patent: September 22, 2015
    Assignee: HYDRA BIOSCIENCES, INC.
    Inventors: Jayhong A. Chong, Christopher Fanger, Magdalene M. Moran, Elisha Singer, Timothy Strassmaier, Howard Ng
  • Sperm-Specific Cation Channel, Catsper3, and Uses Therefor
    Publication number: 20150219626
    Abstract: Nucleic acid and protein sequences relating to a cation channel which is sperm-specific (CatSper3) are disclosed. The CatSper3 protein is shown to be specifically expressed in sperm. Nucleic acids, vectors, transformed cells, transgenic animals, polypeptides, and antibodies relating to the CatSper3 gene and protein are disclosed. Also provided are methods of in vitro fertilization and contraception, methods of identifying modulators of CatSper3 activity, methods of genotyping subjects with respect to CatSper3, and methods of diagnosing and treating CatSper3-mediated disorders, including infertility. Related business methods are also disclosed.
    Type: Application
    Filed: September 5, 2014
    Publication date: August 6, 2015
    Inventors: Magdalene M. MORAN, Jayhong A. CHONG, Ian S. RAMSEY, David CLAPHAM
  • SPERM-SPECIFIC CATION CHANNEL, CATSPER4, AND USES THEREFOR
    Publication number: 20150212069
    Abstract: Nucleic acid and protein sequences relating to a cation channel which is sperm-specific (CatSper4) are disclosed. The CatSper4 protein is shown to be specifically expressed in sperm. Nucleic acids, vectors, transformed cells, transgenic animals, polypeptides, and antibodies relating to the CatSper4 gene and protein are disclosed. Also provided are methods of in vitro fertilization and contraception, methods of identifying modulators of CatSper4 activity, methods of genotyping subjects with respect to CatSper4, and methods of diagnosing and treating CatSper4-mediated disorders, including infertility. Related business methods are also disclosed.
    Type: Application
    Filed: August 13, 2014
    Publication date: July 30, 2015
    Inventors: Magdalene M. MORAN, Jayhong A. CHONG, Ian S. RAMSEY, David CLAPHAM
  • Methods of using voltage-gated Hv1 proton channels to detect changes in intracellular pH
    Patent number: 9068018
    Abstract: Nucleic acid and protein sequences relating to a proton channel (Hv1) are disclosed. Nucleic acids, vectors, transformed cells, transgenic animals, polypeptides, and antibodies relating to the Hv1 gene and protein are disclosed. Also provided are methods of identifying modulators of Hv1 activity, methods of geno typing subjects with respect to Hv1, and methods of diagnosing and treating Hv1-mediated disorders.
    Type: Grant
    Filed: February 15, 2007
    Date of Patent: June 30, 2015
    Assignee: Children's Medical Center Corporation
    Inventors: Ian S. Ramsey, Magdalene M. Moran, Jayhong A. Chong, David Clapham
  • Modulators of sperm hypermobility and uses thereof
    Patent number: 8952041
    Abstract: The invention provides novel compositions and compounds that inhibit CatSper channel activity, that preferentially inhibits sperm hyperactivity over sperm motility, or both. The compounds of the invention are useful as contraceptive agents that may be adminstered to males, females, or concurrently to both sexual partners. The invention further provides methods of conducting drug discovery business and of conducting a reproductive medicine business. The invention also provides methods of identifying compounds that modulate sperm hypermotility.
    Type: Grant
    Filed: November 2, 2012
    Date of Patent: February 10, 2015
    Assignee: Hydra Biosciences, Inc.
    Inventors: Jayhong A. Chong, Magdalene M. Moran
  • Compounds for modulating TRPV3 function
    Patent number: 8916550
    Abstract: The present application relates to compounds and methods for treating pain and other conditions related to TRPV3.
    Type: Grant
    Filed: November 15, 2006
    Date of Patent: December 23, 2014
    Assignee: Hydra Biosciences, Inc.
    Inventors: Jayhong A. Chong, Christopher Fanger, Glenn R. Larsen, William C. Lumma, Jr., Magdalene M. Moran, Amy Ripka, Dennis John Underwood, Manfred Weigele, Xiaoguang Zhen, Anu Mahadevan, Peter Meltzer
  • Sperm-specific cation channel, CATSPER3, and uses therefor
    Patent number: 8859197
    Abstract: Nucleic acid and protein sequences relating to a cation channel which is sperm-specific (CatSper3) are disclosed. The CatSper3 protein is shown to be specifically expressed in sperm. Nucleic acids, vectors, transformed cells, transgenic animals, polypeptides, and antibodies relating to the CatSper3 gene and protein are disclosed. Also provided are methods of in vitro fertilization and contraception, methods of identifying modulators of CatSper3 activity, methods of genotyping subjects with respect to CatSper3, and methods of diagnosing and treating CatSper3-mediated disorders, including infertility. Related business methods are also disclosed.
    Type: Grant
    Filed: January 30, 2012
    Date of Patent: October 14, 2014
    Assignee: Children's Medical Center Corporation
    Inventors: Magdalene M. Moran, Jayhong A. Chong, Ian S. Ramsey, David Clapham
  • COMPOUNDS AND COMPOSITIONS FOR TREATING CHEMICAL WARFARE AGENT-INDUCED INJURIES
    Publication number: 20140303192
    Abstract: Compounds and compositions for treating injuries caused by exposure to chemical warfare agents are described herein.
    Type: Application
    Filed: March 5, 2014
    Publication date: October 9, 2014
    Applicant: HYDRA BIOSCIENCES, INC.
    Inventor: Jayhong A. Chong
  • Sperm-specific cation channel, CatSper4, and uses therefor
    Patent number: 8835105
    Abstract: Nucleic acid and protein sequences relating to a cation channel which is sperm-specific (CatSper4) are disclosed. The CatSper4 protein is shown to be specifically expressed in sperm. Nucleic acids, vectors, transformed cells, transgenic animals, polypeptides, and antibodies relating to the CatSper4 gene and protein are disclosed. Also provided are methods of in vitro fertilization and contraception, methods of identifying modulators of CatSper4 activity, methods of genotyping subjects with respect to CatSper4, and methods of diagnosing and treating CatSper4-mediated disorders, including infertility. Related business methods are also disclosed.
    Type: Grant
    Filed: February 10, 2012
    Date of Patent: September 16, 2014
    Assignee: Children's Medical Center Corporation
    Inventors: Magdalene M. Moran, Jayhong A. Chong, Ian S. Ramsey, David Clapham
  • METHODS AND COMPOSITIONS FOR TREATING PAIN
    Publication number: 20140221401
    Abstract: The present application relates to compounds and methods for treating pain, incontinence and other conditions.
    Type: Application
    Filed: August 14, 2013
    Publication date: August 7, 2014
    Applicant: HYDRA BIOSCIENCES, INC.
    Inventors: Magdalene M. Moran, Christopher Fanger, Jayhong A. Chong, Colleen McNamara, Xiaoguang Zhen, Josh Mandel-Brehm
  • INHIBITING TRPA1 FOR THE TREATMENT OF ASTHMA
    Publication number: 20140158116
    Abstract: This disclosure describes novel compounds and pharmaceutical compositions for inhibiting the TRPA1 ion channel and/or medical conditions related to TRPA1, such as asthma.
    Type: Application
    Filed: August 9, 2013
    Publication date: June 12, 2014
    Applicant: Cubist Pharmaceuticals, Inc.
    Inventors: Jayhong A. Chong, Scott C. Coleman, Rory Curtis, Donato del Camino, Yu Gui Gu, Qingyi Li, Blaise S. Lippa, Chester A. Metcalf, III, Magdalene M. Moran, Michael D. Ryan, Dong Zou
  • COMPOUNDS FOR MODULATING TRPV3 FUNCTION
    Publication number: 20140155417
    Abstract: The present application relates to compounds and methods for treating pain and other conditions related to TRPV3.
    Type: Application
    Filed: August 30, 2013
    Publication date: June 5, 2014
    Applicant: HYDRA BIOSCIENCES, INC.
    Inventors: Jayhong A. Chong, Christopher Fanger, Glenn R. Larsen, William C. Lumma, JR., Anu Mahadevan, Peter Meltzer, Magdalene M. Moran, Amy Ripka, Dennis Underwood, Manfred Weigele, Xiaoguang Zhen
  • Compounds and compositions for treating chemical warfare agent-induced injuries
    Patent number: 8710052
    Abstract: Compounds and compositions for treating injuries caused by exposure to chemical warfare agents are described herein.
    Type: Grant
    Filed: October 18, 2012
    Date of Patent: April 29, 2014
    Assignee: Hydra Biosciences, Inc.
    Inventor: Jayhong A. Chong
  • METHODS AND COMPOSITIONS FOR TREATING ANXIETY
    Publication number: 20140100230
    Abstract: Methods of treating a TRPC5 mediated disorder in a subject by administering an effective amount of a TRPC5 antagonist, such as a compound disclosed herein, are described.
    Type: Application
    Filed: December 10, 2013
    Publication date: April 10, 2014
    Applicant: HYDRA BIOSCIENCES, INC.
    Inventors: Jayhong A. Chong, Christopher Fanger, Magdalene M. Moran, Elisha Singer, Timothy Strassmaier, Howard Ng
  • Methods and compositions for treating anxiety
    Patent number: 8633233
    Abstract: Methods of treating a TRPC5 mediated disorder in a subject by administering an effective amount of a TRPC5 antagonist, such as a compound disclosed herein, are described.
    Type: Grant
    Filed: August 6, 2009
    Date of Patent: January 21, 2014
    Assignee: Hydra Biosciences, Inc.
    Inventors: Jayhong Chong, Christopher Fanger, Magdalene M. Moran, Elisha Singer, Timothy Strassmaier, Howard Ng
  • Compounds of Modulating TRPV3 Function
    Publication number: 20140011840
    Abstract: The present application relates to compounds and methods for treating pain and other conditions related to TRPV3.
    Type: Application
    Filed: January 29, 2013
    Publication date: January 9, 2014
    Applicant: Hydra Biosciences, Inc.
    Inventors: Magadalene M. Moran, Jayhong A. Chong, Christopher Fanger, Amy S. Ripka, Glenn R. Larsen, Xiaoguang Zhen, Dennis John Underwood, Manfred Weigele
  • Substituted pyrimido 4.5-d pyrimidin-4-one compounds for modulating TRPV3 function
    Patent number: 8552009
    Abstract: The present application relates to compounds of Formula I as defined herein, and methods for treating pain and other conditions related to TRPV3.
    Type: Grant
    Filed: February 7, 2011
    Date of Patent: October 8, 2013
    Inventors: Jayhong A. Chong, Christopher Fanger, Glenn R. Larsen, William C. Lumma, Jr., Magdalene M. Moran, Amy S. Ripka, Dennis John Underwood, Manfred Weigele, Xiaoguang Zhen, Anu Mahadevan, Peter Meltzer