Patents by Inventor Jayme Franklin

Jayme Franklin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS AND COMPOSITIONS COMPRISING PURIFIED RECOMBINANT POLYPEPTIDES
    Publication number: 20230250165
    Abstract: Purified recombinant polypeptides isolated from Chinese hamster ovary host cells, including antibodies, such as therapeutic antibodies, and methods of making and using such polypeptides are provided.
    Type: Application
    Filed: April 21, 2023
    Publication date: August 10, 2023
    Applicant: Genentech, Inc.
    Inventors: X. Christopher Yu, Saloumeh Kadkhodayan Fischer, Susan C. Fisher, John Lowe, Atia Naim, Ailen M. Sanchez, Christopher A. Teske, Martin Vanderlaan, Annamarie Amurao, Jayme Franklin, Corazon Victa
  • METHODS OF CONJUGATING AN AGENT TO A THIOL MOIETY IN A PROTEIN THAT CONTAINS AT LEAST ONE TRISULFIDE BOND
    Publication number: 20220372141
    Abstract: The invention provides improved methods of conjugating an agent to a thiol moiety in a protein that contains at least one disulfide bond and at least one trisulfide bond. Exemplary embodiments include the production of antibody drug conjugates substantially free of impurities created in the presence of reactive sulfide moieties in the production processes.
    Type: Application
    Filed: May 24, 2022
    Publication date: November 24, 2022
    Applicant: Genentech, Inc.
    Inventors: Jayme FRANKLIN, Xin Xin LIN, Jeffrey GORRELL, Timothy TULLY, Matthew HUTCHINSON, Charity Tucker BECHTEL
  • Methods of conjugating an agent to a thiol moiety in a protein that contains at least one sulfide bond
    Patent number: 11370838
    Abstract: The invention provides improved methods of conjugating an agent to a thiol moiety in a protein that contains at least one disulfide bond and at least one trisulfide bond. Exemplary embodiments include the production of antibody drug conjugates substantially free of impurities created in the presence of reactive sulfide moieties in the production processes.
    Type: Grant
    Filed: January 24, 2017
    Date of Patent: June 28, 2022
    Assignee: GENENTECH, INC.
    Inventors: Jayme Franklin, Xin Xin Lin, Jeffrey Gorrell, Timothy Tully, Matthew Hutchinson, Charity Tucker Bechtel
  • METHODS AND COMPOSITIONS COMPRISING PURIFIED RECOMBINANT POLYPEPTIDES
    Publication number: 20210115126
    Abstract: Purified recombinant polypeptides isolated from Chinese hamster ovary host cells, including antibodies, such as therapeutic antibodies, and methods of making and using such polypeptides are provided.
    Type: Application
    Filed: September 24, 2020
    Publication date: April 22, 2021
    Applicant: Genentech, Inc.
    Inventors: X. Christopher Yu, Saloumeh Kadkhodayan Fischer, Susan C. Fisher, John Lowe, Atia Naim, Ailen M. Sanchez, Christopher A. Teske, Martin Vanderlaan, Annamarie Amurao, Jayme Franklin, Corazon Victa
  • Methods and compositions comprising purified recombinant polypeptides
    Patent number: 10822404
    Abstract: Purified recombinant polypeptides isolated from Chinese hamster ovary host cells, including antibodies, such as therapeutic antibodies, and methods of making and using such polypeptides are provided.
    Type: Grant
    Filed: February 22, 2018
    Date of Patent: November 3, 2020
    Assignee: Genentech, Inc.
    Inventors: X. Christopher Yu, Susan C. Fisher, Atia Naim, Ailen M. Sanchez, Christopher A. Teske, Martin Vanderlaan, Annamarie Amurao, Jayme Franklin, Corazon Victa
  • METHODS AND COMPOSITIONS COMPRISING PURIFIED RECOMBINANT POLYPEPTIDES
    Publication number: 20180291095
    Abstract: Purified recombinant polypeptides isolated from Chinese hamster ovary host cells, including antibodies, such as therapeutic antibodies, and methods of making and using such polypeptides are provided.
    Type: Application
    Filed: February 22, 2018
    Publication date: October 11, 2018
    Applicant: Genentech, Inc.
    Inventors: X. Christopher Yu, Saloumeh Kadkhodayan Fischer, Susan C. Fisher, John Lowe, Atia Naim, Ailen M. Sanchez, Christopher A. Teske, Martin Vanderlaan, Annamarie Amurao, Jayme Franklin, Corazon Victa
  • METHODS OF CONJUGATING AN AGENT TO A THIOL MOIETY IN A PROTEIN THAT CONTAINS AT LEAST ONE SULFIDE BOND
    Publication number: 20170209593
    Abstract: The invention provides improved methods of conjugating an agent to a thiol moiety in a protein that contains at least one disulfide bond and at least one trisulfide bond. Exemplary embodiments include the production of antibody drug conjugates substantially free of impurities created in the presence of reactive sulfide moieties in the production processes.
    Type: Application
    Filed: January 24, 2017
    Publication date: July 27, 2017
    Inventors: Jayme FRANKLIN, Xin Xin LIN, Jeffrey GORRELL, Timothy TULLY, Matthew HUTCHINSON, Charity Tucker BECHTEL
  • METHODS AND COMPOSITIONS COMPRISING PURIFIED RECOMBINANT POLYPEPTIDES
    Publication number: 20160319012
    Abstract: Purified recombinant polypeptides isolated from Chinese hamster ovary host cells, including antibodies, such as therapeutic antibodies, and methods of making and using such polypeptides are provided.
    Type: Application
    Filed: March 9, 2016
    Publication date: November 3, 2016
    Applicant: Genentech, Inc.
    Inventors: X. Christopher Yu, Saloumeh Kadkhodayan Fischer, Susan C. Fisher, John Lowe, Atia Naim, Ailen M. Sanchez, Christopher A. Teske, Martin Vanderlaan, Annamarie Amurao, Jayme Franklin, Corazon Victa
  • Polyelectrolyte precipitation and purification of proteins
    Patent number: 7947813
    Abstract: Methods are presented for isolating and purifying proteins by adding a polyelectrolyte to a cell culture fluid, such as a harvested cell culture fluid, and precipitating a protein-polyelectrolyte complex or a complex of impurities and the polyelectrolyte.
    Type: Grant
    Filed: January 10, 2008
    Date of Patent: May 24, 2011
    Assignee: Genentech, Inc.
    Inventors: Robert L. Fahrner, Jayme Franklin, Paul McDonald, Thanmaya Peram, Vikram Sisodiya, Corazon Victa
  • POLYELECTROLYTE PRECIPITATION AND PURIFICATION OF PROTEINS
    Publication number: 20080193981
    Abstract: Methods are presented for isolating and purifying proteins by adding a polyelectrolyte to a cell culture fluid, such as a harvested cell culture fluid, and precipitating a protein-polyelectrolyte complex or a complex of impurities and the polyelectrolyte.
    Type: Application
    Filed: January 10, 2008
    Publication date: August 14, 2008
    Inventors: Robert L. Fahrner, Jayme Franklin, Paul McDonald, Thanmaya Peram, Vikram Sisodiya, Corazon Victa