Patents by Inventor Jayme NORDIN

Jayme NORDIN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Codon-optimized acid alpha-glucosidase expression cassettes and methods of using same
    Patent number: 12084693
    Abstract: The invention provides nucleic acids encoding acid ?-glucosidase (GAA). In certain embodiments, nucleic acids have greater than about 86% sequence identity to a sequence selected from the group consisting of any of the sequences set forth as SEQ ID NOs:1-5. In certain embodiments, nucleic acids encoding acid ?-glucosidase (GAA) contain less than 127 CpG dinucleotides. Expression cassettes, vectors, cells and cell lines and methods of using such nucleic acids encoding acid ?-glucosidase (GAA) are also provided.
    Type: Grant
    Filed: May 15, 2019
    Date of Patent: September 10, 2024
    Assignee: SPARK THERAPEUTICS, INC.
    Inventors: Xavier Anguela, Sean Armour, Jayme Nordin
  • CODON-OPTIMIZED ACID ALPHA-GLUCOSIDASE EXPRESSION CASSETTES AND METHODS OF USING SAME
    Publication number: 20210222141
    Abstract: The invention provides nucleic acids encoding acid a-glucosidase (GAA). In certain embodiments, nucleic acids have greater than about 86% sequence identity to a sequence selected from the group consisting of any of the sequences set forth as SEQ ID NOs:1-5. In certain embodiments, nucleic acids encoding acid a-glucosidase (GAA) contain less than 127 CpG dinucleotides. Expression cassettes, vectors, cells and cell lines and methods of using such nucleic acids encoding acid a-glucosidase (GAA) are also provided.
    Type: Application
    Filed: May 15, 2019
    Publication date: July 22, 2021
    Applicant: SPARK THERAPEUTICS, INC.
    Inventors: Xavier ANGUELA, Sean ARMOUR, Jayme NORDIN