Patents by Inventor Jayson Bowers

Jayson Bowers has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NUCLEOTIDE ANALOGS
    Publication number: 20160168636
    Abstract: The invention generally relates to nucleotide analogs and methods of their use in sequencing-by-synthesis reactions. In certain embodiments, the invention provides a nucleotide analog including a detectable label attached to a nitrogenous base portion of a nucleotide analog by a cleavable linker, in which contact of the analog with at least one activating agent results in cleavage of the label and elimination of the linker, thereby producing a natural nucleotide, a 9-deaza-G, 9-deaza-A, or ?-uridine.
    Type: Application
    Filed: October 14, 2015
    Publication date: June 16, 2016
    Inventors: Suhaib Siddiqi, J. William Efcavitch, Judith Mitchell, Subramanian Marappan, Jayson Bowers, Mirna Jaroza
  • Nucleotide analogs
    Patent number: 9163053
    Abstract: The invention generally relates to nucleotide analogs and methods of their use in sequencing-by-synthesis reactions. In certain embodiments, the invention provides a nucleotide analog including a detectable label attached to a nitrogenous base portion of a nucleotide analog by a cleavable linker, in which contact of the analog with at least one activating agent results in cleavage of the label and elimination of the linker, thereby producing a natural nucleotide, a 9-deaza-G, 9-deaza-A, or ?-uridine.
    Type: Grant
    Filed: December 4, 2009
    Date of Patent: October 20, 2015
    Assignee: Fluidigm Corporation
    Inventors: Suhaib Siddiqi, J. William Efcavitch, Judith Mitchell, Subramanian Marappan, Jayson Bowers, Mirna Jaroza
  • NUCLEOTIDE ANALOGS
    Publication number: 20120040340
    Abstract: The invention provides for nucleotide analogs and methods of using the same, e.g., for sequencing nucleic acids.
    Type: Application
    Filed: October 27, 2011
    Publication date: February 16, 2012
    Applicant: HELICOS BIOSCIENCES CORPORATION
    Inventors: J. William Efcavitch, Suhaib Siddiqi, Philip R. Buzby, Judith Mitchell, Edyta Krzymanska-Olejnik, Subramanian Marappan, Xiaopeng Bai, Atanu Roy, Mirna Jarosz, Jayson Bowers
  • METHODS, FLOW CELLS AND SYSTEMS FOR SINGLE CELL ANALYSIS
    Publication number: 20120028822
    Abstract: A method, flow cell and/or device for increasing the recovery of a limiting analyte in a sample, e.g., for single molecule analysis is disclosed. Methods for preparing a nucleic acid sample from a single cell and capturing nucleic acids on a surface configured for use in or with single molecule analysis are also provided.
    Type: Application
    Filed: November 4, 2009
    Publication date: February 2, 2012
    Applicant: HELICOS BIOSCIENCES CORPORATION
    Inventors: Richard Joseph, James Dimeo, Mirna Jarosz, John F. Thompson, Jayson Bowers, Scott Chouinard, Philipp Kapranov, William J. Efcavitch, Christopher Hart, Fatih Ozsolak
  • Nucleotide analogs
    Patent number: 8071755
    Abstract: The invention provides for nucleotide analogs and methods of using the same, e.g., for sequencing nucleic acids.
    Type: Grant
    Filed: April 4, 2008
    Date of Patent: December 6, 2011
    Assignee: Helicos Biosciences Corporation
    Inventors: J. William Efcavitch, Suhaib Siddiqi, Philip R. Buzby, Judith Mitchell, Edyta Krzymanska-Olejnik, Subramanian Marappan, Xiaopeng Bai, Atanu Roy, Mirna Jarosz, Jayson Bowers
  • NUCLEOTIDE ANALOGS
    Publication number: 20110081647
    Abstract: The invention generally relates to nucleotide analogs and methods of their use in sequencing-by-synthesis reactions. In certain embodiments, the invention provides a nucleotide analog including a detectable label attached to a nitrogenous base portion of a nucleotide analog by a cleavable linker, in which contact of the analog with at least one activating agent results in cleavage of the label and elimination of the linker, thereby producing a natural nucleotide, a 9-deaza-G, 9-deaza-A, or ?-uridine.
    Type: Application
    Filed: December 4, 2009
    Publication date: April 7, 2011
    Applicant: HELICOS BIOSCIENCES CORPORATION
    Inventors: Suhaib Siddiqi, J. William Efcavitch, Judith Mitchell, Subramanian Marappan, Jayson Bowers, Mirna Jaroza
  • METHODS, FLOW CELLS AND SYSTEMS FOR SINGLE CELL ANALYSIS
    Publication number: 20100233696
    Abstract: A method, flow cell and/or device for increasing the recovery of a limiting analyte in a sample, e.g., for single molecule analysis is disclosed. Methods for preparing a nucleic acid sample from a single cell and capturing nucleic acids on a surface configured for use in or with single molecule analysis are also provided.
    Type: Application
    Filed: November 4, 2009
    Publication date: September 16, 2010
    Applicant: HELICOS BIOSCIENCES CORPORATION
    Inventors: Richard Joseph, James J. DiMeo, Mirna Jarosz, John F. Thompson, Jayson Bowers, Scott Chouinard, Philipp Kapronov, J. William Efcavitch, Christopher Hart, Fatih Ozsolak
  • COMPETITOR MOLECULES USEFUL FOR LOWERING NONSPECIFIC ADSORPTION OF DYE LABELED NUCLEOTIDES
    Publication number: 20100190168
    Abstract: Methods are described which enable higher signal/noise when performing surface measurements at the single molecule level. Methods are particularly useful in the field of molecular biology when performing single molecule nucleic acid sequencing by synthesis using dye labeled nucleotides. The method employs using a competitor molecule which blocks nonspecific binding of analog molecules to the surface.
    Type: Application
    Filed: December 2, 2009
    Publication date: July 29, 2010
    Applicant: HELICOS BIOSCIENCES CORPORATION
    Inventors: Philip Buzby, Jayson Bowers
  • Methods for Reducing Contaminants in Nucleic Acid Sequencing by Synthesis
    Publication number: 20090226900
    Abstract: The disclosure provides methods that improve fidelity of the sequencing-by-synthesis reactions, including methods that reduce impurities and contamination in various reagents, reaction mixtures, and other components of the sequencing systems.
    Type: Application
    Filed: March 5, 2008
    Publication date: September 10, 2009
    Applicant: HELICOS BIOSCIENCES CORPORATION
    Inventors: Hazen Babcock, Mirna Jarosz, Jennifer Colonell, Parris Wellman, Geoff Lowman, Jayson Bowers, John Kepler
  • Nucleotide Analogs
    Publication number: 20090061437
    Abstract: The invention provides for nucleotide analogs and methods of using the same, e.g., for sequencing nucleic acids.
    Type: Application
    Filed: April 4, 2008
    Publication date: March 5, 2009
    Applicant: HELICOS BIOSCIENCES CORPORATION
    Inventors: J. William Efcavitch, Suhaib Siddiqi, Philip R. Buzby, Judith Mitchell, Edyta Krzymanska-Olejnik, Subramanian Marappan, Xiaopeng Bai, Atanu Roy, Mirna Jarosz, Jayson Bowers