Patents by Inventor Je-Hyuk Lee

Je-Hyuk Lee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and Methods for Analyte Detection
    Publication number: 20250129408
    Abstract: The inventions provided herein relate to detection reagents, compositions, methods, and kits comprising the detection reagents for use in detection, identification, and/or quantification of analytes in a sample. Such detection reagents and methods described herein allow multiplexing of many more labeled species in the same procedure than conventional methods, in which multiplexing is limited by the number of available and practically usable colors.
    Type: Application
    Filed: December 20, 2024
    Publication date: April 24, 2025
    Inventors: Daniel Levner, Je-Hyuk Lee, George M. Church, Michael Super
  • Method for Generating A Three-Dimensional Nucleic Acid Containing Matrix
    Publication number: 20240301468
    Abstract: Methods of making a three-dimensional matrix of nucleic acids within a cell is provided.
    Type: Application
    Filed: May 2, 2024
    Publication date: September 12, 2024
    Inventors: George M. Church, Je-hyuk Lee, Richard C. Terry, Evan R. Daugharthy
  • Method for Generating A Three-Dimensional Nucleic Acid Containing Matrix
    Publication number: 20240287582
    Abstract: Methods of making a three-dimensional matrix of nucleic acids within a cell is provided.
    Type: Application
    Filed: May 2, 2024
    Publication date: August 29, 2024
    Inventors: George M. Church, Je-hyuk Lee, Richard C. Terry, Evan R. Daugharthy
  • Compositions and Methods for Analyte Detection
    Publication number: 20240018569
    Abstract: The inventions provided herein relate to detection reagents, compositions, methods, and kits comprising the detection reagents for use in detection, identification, and/or quantification of analytes in a sample. Such detection reagents and methods described herein allow multiplexing of many more labeled species in the same procedure than conventional methods, in which multiplexing is limited by the number of available and practically usable colors.
    Type: Application
    Filed: August 31, 2023
    Publication date: January 18, 2024
    Inventors: Daniel Levner, Je-Hyuk Lee, George M. Church, Michael Super
  • Method and Apparatus for Volumetric Imaging
    Publication number: 20230279484
    Abstract: Methods of volumetric imaging of a three-dimensional matrix of nucleic acids within a cell is provided. An automated apparatus for sequencing and volumetric imaging of a three-dimensional matrix of nucleic acids is provided.
    Type: Application
    Filed: September 30, 2022
    Publication date: September 7, 2023
    Inventors: Evan R. Daugharthy, Richard C. Terry, Je-Hyuk Lee, George M. Church, Benjamin W. Pruitt
  • Methods for High-Throughput Labelling and Detection of Biological Features in Situ Using Microscopy
    Publication number: 20230227895
    Abstract: Methods of labelling one or more subcellular components (e.g., an organelle and/or subcellular region) in vivo are provided. Methods of labelling a protein in vivo are provided. Methods of determining a nucleic acid sequence in situ are also provided.
    Type: Application
    Filed: January 20, 2023
    Publication date: July 20, 2023
    Inventors: George M. Church, Je-Hyuk Lee, Evan R. Daugharthy
  • Compositions and Methods for Analyte Detection
    Publication number: 20230146985
    Abstract: The inventions provided herein relate to detection reagents, compositions, methods, and kits comprising the detection reagents for use in detection, identification, and/or quantification of analytes in a sample. Such detection reagents and methods described herein allow multiplexing of many more labeled species in the same procedure than conventional methods, in which multiplexing is limited by the number of available and practically usable colors.
    Type: Application
    Filed: December 27, 2022
    Publication date: May 11, 2023
    Inventors: Daniel Levner, Je-Hyuk Lee, George M. Church, Michael Super
  • Method and apparatus for volumetric imaging
    Patent number: 11542554
    Abstract: Methods of volumetric imaging of a three-dimensional matrix of nucleic acids within a cell is provided. An automated apparatus for sequencing and volumetric imaging of a three-dimensional matrix of nucleic acids is provided.
    Type: Grant
    Filed: August 6, 2021
    Date of Patent: January 3, 2023
    Assignee: President and Fellows of Harvard College
    Inventors: Evan R. Daugharthy, Richard C. Terry, Je-Hyuk Lee, George M. Church, Benjamin W. Pruitt
  • Compositions and Methods for Analyte Detection
    Publication number: 20220282301
    Abstract: The inventions provided herein relate to detection reagents, compositions, methods, and kits comprising the detection reagents for use in detection, identification, and/or quantification of analytes in a sample. Such detection reagents and methods described herein allow multiplexing of many more labeled species in the same procedure than conventional methods, in which multiplexing is limited by the number of available and practically usable colors.
    Type: Application
    Filed: May 19, 2022
    Publication date: September 8, 2022
    Inventors: Daniel Levner, Je-hyuk Lee, George M. Church, Michael Super
  • Method for Generating A Three-Dimensional Nucleic Acid Containing Matrix
    Publication number: 20220228196
    Abstract: Methods of making a three-dimensional matrix of nucleic acids within a cell is provided.
    Type: Application
    Filed: March 30, 2022
    Publication date: July 21, 2022
    Inventors: George M. Church, Je-Hyuk Lee, Richard C. Terry, Evan R. Daugharthy
  • Method for generating a three-dimensional nucleic acid containing matrix
    Patent number: 11299767
    Abstract: Methods of making a three-dimensional matrix of nucleic acids within a cell is provided.
    Type: Grant
    Filed: June 30, 2021
    Date of Patent: April 12, 2022
    Assignee: President and Fellows of Harvard College
    Inventors: George M. Church, Je-Hyuk Lee, Richard C. Terry, Evan R. Daugharthy
  • Compositions and methods for analyte detection
    Patent number: 11293054
    Abstract: The inventions provided herein relate to detection reagents, compositions, methods, and kits comprising the detection reagents for use in detection, identification, and/or quantification of analytes in a sample. Such detection reagents and methods described herein allow multiplexing of many more labeled species in the same procedure than conventional methods, in which multiplexing is limited by the number of available and practically usable colors.
    Type: Grant
    Filed: April 24, 2019
    Date of Patent: April 5, 2022
    Assignee: President and Fellows of Harvard College
    Inventors: Daniel Levner, Je-hyuk Lee, George M. Church, Michael Super
  • Compositions and Methods for Analyte Detection
    Publication number: 20220025448
    Abstract: The inventions provided herein relate to detection reagents, compositions, methods, and kits comprising the detection reagents for use in detection, identification, and/or quantification of analytes in a sample. Such detection reagents and methods described herein allow multiplexing of many more labeled species in the same procedure than conventional methods, in which multiplexing is limited by the number of available and practically usable colors.
    Type: Application
    Filed: October 12, 2021
    Publication date: January 27, 2022
    Inventors: Daniel Levner, Je-Hyuk Lee, George M. Church, Michael Super
  • Method and Apparatus for Volumetric Imaging
    Publication number: 20210363579
    Abstract: Methods of volumetric imaging of a three-dimensional matrix of nucleic acids within a cell is provided. An automated apparatus for sequencing and volumetric imaging of a three-dimensional matrix of nucleic acids is provided.
    Type: Application
    Filed: August 6, 2021
    Publication date: November 25, 2021
    Inventors: Evan R. Daugharthy, Richard C. Terry, Je-Hyuk Lee, George M. Church, Benjamin W. Pruitt
  • Method for Generating A Three-Dimensional Nucleic Acid Containing Matrix
    Publication number: 20210324450
    Abstract: Methods of making a three-dimensional matrix of nucleic acids within a cell is provided.
    Type: Application
    Filed: June 30, 2021
    Publication date: October 21, 2021
    Inventors: George M. Church, Je-Hyuk Lee, Richard C. Terry, Evan R. Daugharthy
  • Method and apparatus for volumetric imaging of a three-dimensional nucleic acid containing matrix
    Patent number: 11118220
    Abstract: Methods of volumetric imaging of a three-dimensional matrix of nucleic acids within a cell is provided. An automated apparatus for sequencing and volumetric imaging of a three-dimensional matrix of nucleic acids is provided.
    Type: Grant
    Filed: April 17, 2019
    Date of Patent: September 14, 2021
    Assignee: President and Fellows of Harvard College
    Inventors: Evan R. Daugharthy, Richard C. Terry, Je-hyuk Lee, George M. Church, Benjamin W. Pruitt
  • Compositions and methods for analyte detection
    Patent number: 11111521
    Abstract: Methods of making a three-dimensional matrix of nucleic acids within a cell is provided.
    Type: Grant
    Filed: December 15, 2020
    Date of Patent: September 7, 2021
    Assignee: President and Fellows of Harvard College
    Inventors: George M. Church, Je-hyuk Lee, Richard C. Terry, Evan R. Daugharthy
  • Method for generating a three-dimensional nucleic acid containing matrix
    Patent number: 11078520
    Abstract: Methods of making a three-dimensional matrix of nucleic acids within a cell is provided.
    Type: Grant
    Filed: October 11, 2018
    Date of Patent: August 3, 2021
    Assignee: President and Fellows of Harvard College
    Inventors: George M. Church, Je-Hyuk Lee, Richard C. Terry, Evan R. Daugharthy
  • Compositions and methods for analyte detection
    Patent number: 11021737
    Abstract: Methods of making a three-dimensional matrix of nucleic acids within a cell is provided.
    Type: Grant
    Filed: July 29, 2020
    Date of Patent: June 1, 2021
    Assignee: President and Fellows of Harvard College
    Inventors: George M. Church, Je-hyuk Lee, Daniel Levner, Michael Super
  • Method for Generating A Three-Dimensional Nucleic Acid Containing Matrix
    Publication number: 20210102238
    Abstract: Methods of making a three-dimensional matrix of nucleic acids within a cell is provided.
    Type: Application
    Filed: December 15, 2020
    Publication date: April 8, 2021
    Inventors: George M. Church, Je-hyuk Lee, Richard C. Terry, Evan R. Daugharthy