Abstract: Supramolecular assemblies, compositions thereof, and methods for preparing and use the same are provided. The supramolecular assemblies comprise a trimeric variant of a GCN4 peptide capable of self-assembly and incorporating one or more guest molecules in a functional 3D native structure.

Abstract: The present disclosure relates to novel cleavable conjugates of antibiotics and an antibacterial cell-penetrating peptide, and methods to make and use the novel cleavable conjugates of antibiotics and an antibacterial cell-penetrating peptide.

Abstract: Described herein are conjugates of collagen peptides and metal binding agents and compositions resulting therefrom, useful in various tissue engineering and regeneration applications, in cell culture, cell adhesion, cosmetic surgery, construction of artificial skin substitutes, management of severe burns and burn surgery, reconstruction of bone and a wide variety of dental, orthopedic and surgical purposes, as drug delivery vehicles and in delivering populations of cells to a site of disease or injury.

Abstract: Described herein are conjugates of collagen peptides and metal binding agents and compositions resulting therefrom, useful in various tissue engineering and regeneration applications, in cell culture, cell adhesion, cosmetic surgery, construction of artificial skin substitutes, management of severe burns and burn surgery, reconstruction of bone and a wide variety of dental, orthopedic and surgical purposes, as drug delivery vehicles and in delivering populations of cells to a site of disease or injury.

Abstract: A method for inhibiting therapeutic drug resistance within a cell over-expressing a membrane protein is provided. The method comprises synthesizing a dimeric prodrug inhibitor of a monomeric therapeutic agent; administering the dimeric prodrug inhibitor to the membrane protein together with the monomeric therapeutic agent; and occupying at least one substrate binding site of the membrane protein with the synthesized dimeric prodrug to allow the monomeric therapeutic agent to accumulate within the cell. The dimeric prodrug inhibitor contains a crosslinking agent that is adapted to breakdown under reducing conditions within the cytosol of the cell to cause the dimeric prodrug to revert back to a form equivalent to the monomeric therapeutic agent.

Abstract: Pharmaceutical compositions comprising crystals of a pharmaceutically-acceptable crystal lattice component, and an active pharmaceutical ingredient different from and included within the crystal lattice component in a growth-sector specific orientation. The crystals are prepared using components and methods which yield crystals having suitable purity and efficacy for use in administering the active pharmaceutical ingredients to a patient. The crystals are typically combined with adjuvants such as excipients, diluents or carriers, and are preferably formulated into tablets, capsules, suspensions, and other conventional forms containing predetermined amounts of the pharmaceuticals. Also provided are methods for preparing the crystals, and methods for storing and administering the active pharmaceutical ingredient either included within the crystals or upon reconstitution of the crystals to a solution.

Abstract: An absorbent article for absorbing body fluids is provided having an absorbent core positioned between a fluid-permeable cover and a fluid-impermeable baffle. The absorbent core includes a central, longitudinal flexure axis which substantially extends the length of the absorbent core. The central, longitudinal axis generally divides the absorbent core into first and second longitudinal members having an outer boundary and wherein the first member has a second flexure axis and the second member has a third flexure axis. Flanking the outer boundary of the first and second members are a third and a fourth longitudinal absorbent member, respectively. The third and fourth absorbent members are positioned so that, when said absorbent article is subjected to lateral compressive forces, the first and second members preferentially bend convexly upward, and said absorbent core generally acquires a “W” shaped configuration.

Abstract: An absorbent article for absorbing body fluids is provided having an absorbent core positioned between a fluid-permeable cover and a fluid-impermeable baffle. The absorbent core includes a central, longitudinal flexure axis which substantially extends the length of the absorbent core. The central, longitudinal axis generally divides the absorbent core into first and second longitudinal members having an outer boundary and wherein the first member has a second flexure axis and the second member has a third flexure axis. Flanking the outer boundary of the first and second members are a third and a fourth longitudinal absorbent members, respectively. The third and fourth absorbent members are positioned so that, when said absorbent article is subjected to lateral compressive forces, the first and second members preferentially bend convexly upward, and said absorbent core generally acquires a “W” shaped configuration.

Abstract: An absorbent article for absorbing body fluids is provided having an absorbent core positioned between a fluid-permeable cover and a fluid-impermeable baffle. The absorbent core includes a central, longitudinal flexure axis which substantially extends the length of the absorbent core. The central, longitudinal axis generally divides the absorbent core into first and second longitudinal members having an outer boundary and wherein the first member has a second flexure axis and the second member has a third flexure axis. Flanking the outer boundary of the first and second members are a third and a fourth longitudinal absorbent member, respectively. The third and fourth absorbent members are positioned so that, when said absorbent article is subjected to lateral compressive forces, the first and second members preferentially bend convexly upward, and said absorbent core generally acquires a “W” shaped configuration.

Abstract: An absorbent article for absorbing body fluids is provided having an absorbent core positioned between a fluid-permeable cover and a fluid-impermeable baffle. The absorbent core includes a central, longitudinal flexure axis which substantially extends the length of the absorbent core. The central, longitudinal axis generally divides the absorbent core into first and second longitudinal members having an outer boundary and wherein the first member has a second flexure axis and the second member has a third flexure axis. Flanking the outer boundary of the first and second members are a third and a fourth longitudinal absorbent member, respectively. The third and fourth absorbent members are positioned so that, when said absorbent article is subjected to lateral compressive forces, the first and second members preferentially bend convexly upward, and said absorbent core generally acquires a "W" shaped configuration.