Abstract: Provided are antibodies that specifically bind to CTLA-4 and/or PD-1 and antagonize CTLA-4 and/or PD-1 function. Also provided are pharmaceutical compositions and kits comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies either alone or in combination.

Abstract: This disclosure provides, among other things, compositions comprising quantities of oltipraz crystals, as well as method of making such compositions, and method of treating patients using such compositions. Taste-modified compositions also are provided.

Abstract: This disclosure provides, among other things, compositions comprising quantities of oltipraz crystals, as well as method of making such compositions, and method of treating patients using such compositions.

Abstract: A magnetic tunnel junction device is disclosed comprising a first device layer comprising a material having a magnetic moment; a second device layer comprising a material having a magnetic moment, e.g., wherein the magnetic moment of the material of the second device layer is different from that of the material of the first device layer; and a barrier layer, e.g., tunnel barrier, having a first interface to the first device layer comprising predominantly of a scandium nitride (ScN) material and having a second interface to the second device layer comprising predominantly of a scandium nitride (ScN) material.

Abstract: A radical departure from the classical E1-E2-E3 three-enzyme mediated ubiquitination of eukaryotes, the bacterial enzymes of the SidE family of Legionella pneumophila effectors utilize NAD+ to ligate ubiquitin onto target substrate proteins achieved via a two-step mechanism involving (1) ADP-ribosylation of ubiquitin followed by (2) phosphotransfer to a target serine residue. Using fluorescent NAD+ analogues as well as synthetic substrate mimics, a continuous assay system enabling real-time monitoring of both steps of this mechanism is disclosed herein. These assays are amenable to biochemical studies and high-throughput screening of inhibitors of these effectors, and enable the discovery and characterization of putative enzymes similar to the SidE family in other organisms.

Abstract: This disclosure provides, among other things, compositions comprising quantities of oltipraz crystals, as well as method of making such compositions, and method of treating patients using such compositions. Taste-modified compositions also are provided.

Abstract: Methods and kits for a dance and exercise program demonstrated to improve quality of life, as measured by interest, depression and anxiety, in geriatric and special needs populations are provided.

Abstract: The present disclosure relates to novel antibacterial cell-penetrating peptides and derivatives, and methods to make and use the novel antibacterial cell-penetrating peptides and derivatives. The novel antibacterial cell-penetrating peptides of the present invention with shorter linker between a pyrrolidine ring and a guanidine group provide unexpectedly higher potency against a broader scope of bacterial.

Abstract: The present disclosure relates to novel cleavable conjugates of antibiotics and an antibacterial cell-penetrating peptide, and methods to make and use the novel cleavable conjugates of antibiotics and an antibacterial cell-penetrating peptide.

Abstract: A wearable device monitors a wearer's physical activity and provides assistance to the wearer. The device includes physiologic sensors that provide sensor data of the wearer to a processor, a user interface that provides information to the wearer, a network interface that provides a network connection between the device and a remote computer, and a memory that stores instructions. The processor executes the instructions to collect physical activity data of the wearer using the sensors, to provide the collected activity data to the remote computer via the network interface to create or update a parameterized rule-based custom data model for the wearer, to receive the custom data model for comparison to collected activity data, and to communicate with the wearer via the user interface when a check of the wearer's activity data against the custom data model indicates that the wearer's activity is not consistent with the custom data model.

Abstract: The present disclosure relates to novel antibacterial cell-penetrating peptides and derivatives, and methods to make and use the novel antibacterial cell-penetrating peptides and derivatives. The novel antibacterial cell-penetrating peptides of the present invention with shorter linker between a pyrrolidine ring and a guanidine group provide unexpectedly higher potency against a broader scope of bacterial.

Abstract: This disclosure provides, among other things, compositions comprising quantities of oltipraz crystals, as well as method of making such compositions, and method of treating patients using such compositions.

Abstract: This disclosure provides, among other things, compositions comprising quantities of oltipraz crystals, as well as method of making such compositions, and method of treating patients using such compositions. Taste-modified compositions also are provided.

Abstract: The present disclosure relates to novel cleavable conjugates of antibiotics and an antibacterial cell-penetrating peptide, and methods to make and use the novel cleavable conjugates of antibiotics and an antibacterial cell-penetrating peptide.

Abstract: The present disclosure relates to novel cleavable conjugates of antibiotics and an antibacterial cell-penetrating peptide, and methods to make and use the novel cleavable conjugates of antibiotics and an antibacterial cell-penetrating peptide.

Abstract: A wearable device monitors a wearer's physical activity and provides assistance to the wearer. The device includes physiologic sensors that provide sensor data of the wearer to a processor, a user interface that provides information to the wearer, a network interface that provides a network connection between the device and a remote computer, and a memory that stores instructions. The processor executes the instructions to collect physical activity data of the wearer using the sensors, to provide the collected activity data to the remote computer via the network interface to create or update a parameterized rule-based custom data model for the wearer, to receive the custom data model for comparison to collected activity data, and to communicate with the wearer via the user interface when a check of the wearer's activity data against the custom data model indicates that the wearer's activity is not consistent with the custom data model.

Abstract: A wearable device is adapted to monitor a wearer's physical activity patterns and to provide assistance to the wearer when a need for assistance is indicated. The device includes a processor is programmed to cause the device to collect activity data necessary to determine the physical activity pattern of the wearer over time, to provide the gathered activity data to a server via a network interface for processing to create or update behavioral rules for the wearer, to receive the behavioral rules from the server for comparison to the received activity data, and to provide to the wearer via the user interface assistance information when the wearer has requested assistance or when a check of the wearer's activity against the behavioral rules indicates that the wearer may need assistance.

Abstract: Distant support is provided to a personal hearing system user by a support provider over a network. Support provider and user communicate with each other by speech transmitted over the network. The user depends in regard to understanding speech on his or her hearing aids. During the support session the hearing aids may have to be removed, may have to be switched off or may be programmed in an unfavorable way. In this case, the user may not be able to understand the speech of the support provider any more. The system enables the support provider to select a message from a list of available messages which is then presented as a visual image to the user. The obstructed acoustical channel is bypassed by relying on visual communication.

Abstract: The present invention cationic amphiphilic polyproline helices (CAPHs) compounds having increased hydrophobicity and cellular internalization as antimicrobial agents. Antimicrobial compositions and methods of using the same are also provided.

Abstract: Embodiments are directed to devices, systems, and methods for monitoring and assisting a subject in various life tasks.