Patents by Inventor Jean-Benoit ARLET

Jean-Benoit ARLET has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and pharmaceutical compositions for the treatment of beta-thalassemias
    Patent number: 9861615
    Abstract: The present invention relates to methods and pharmaceutical compositions for the treatment of beta-thalassemias. In particular, the present invention relates to an XPO1 inhibitor for use in a method for treating beta-thalassemia in a subject in need thereof.
    Type: Grant
    Filed: November 28, 2014
    Date of Patent: January 9, 2018
    Assignees: INSERM (Institut National de la Sante et de la Recherche Medicale), Universite Paris Decartes, Assistance Publique-Hopitaux de Paris (APHP), Fondation Imagine, Centre National de la Recherche Scientifique (CNRS)
    Inventors: Olivier Hermine, Flavia Guillem, Jean-Benoit Arlet, Genevieve Courtois
  • Methods and pharmaceutical compositions for the treatment of myelodysplastic syndromes
    Patent number: 9675590
    Abstract: The present invention provides methods and pharmaceutical compositions designed to intervene in this defective process and to promote or restore erythrocyte maturation in individuals suffering from a myelodysplastic syndrome. The methods involve maintaining the activity of GATA-1 by preventing sequestration of Hsp70 in the cytoplasm. Accordingly, it is an object of this invention to provide methods of restoring or increasing erythrocyte maturation in a subject suffering from a myelodysplastic syndrome by preventing proteolytic inactivation of GATA-1. In some embodiments, preventing is achieved by administering to the subject a compound that inhibits the XPO1 nuclear transporter.
    Type: Grant
    Filed: June 9, 2015
    Date of Patent: June 13, 2017
    Assignees: Institut National de la Sante et de la Recherche Medicale (INSERM), Fondation Imagine, Assistance Publique-Hopitaux de Paris (APHP), Universite Paris Descartes, Centre National de la Recherche Scientifique (CNRS)
    Inventors: Olivier Hermine, Flavia Guillem, Jean-Benoit Arlet, Genevève Courtois, Michaela Fontenay
  • METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF BETA-THALASSEMIAS
    Publication number: 20170020847
    Abstract: The present invention relates to methods and pharmaceutical compositions for the treatment of beta-thalassemias. In particular, the present invention relates to an XPO1 inhibitor for use in a method for treating beta-thalassemia in a subject in need thereof.
    Type: Application
    Filed: November 18, 2014
    Publication date: January 26, 2017
    Applicants: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), UNIVERSITE PARIS DESCARTES, ASSISTANCE PUBLIQUE-HOPITAUX DE PARIS (APHP), FOUNDATION IMAGINE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
    Inventors: Olivier HERMINE, Flavia GUILLEM, Jean-Benoit ARLET, Genevieve COURTOIS
  • METHODS AND COMPOSITIONS FOR THE TREATMENT OF BETA-THALASSEMIA
    Publication number: 20160368975
    Abstract: Methods and compositions for the treatment of ?-thalassemia are provided. Methods and compositions restore or increase erythrocyte maturation in individuals afflicted with ?-TM by preventing proteolysis of GATA-1 protein. Screening methods for identifying agents which bind heat shock protein 70 (HSP-70) and inhibit HSP-70 ?-globin binding, but which allow GATA-1 protein-HSP-1 binding in a manner that prevents GATA-1 proteolysis.
    Type: Application
    Filed: May 23, 2016
    Publication date: December 22, 2016
    Inventors: Olivier HERMINE, Genevieve COURTOIS, Jean-Benoit ARLET, Jean-Antoine RIBEIL
  • Methods and compositions for the treatment of ?-thalassemia
    Patent number: 9377471
    Abstract: Methods and compositions for the treatment of ?-thalassemia are provided. Methods and compositions restore or increase erythrocyte maturation in individuals afflicted with ?-TM by preventing proteolysis of GATA-1 protein. Screening methods for identifying agents which bind heat shock protein 70 (HSP-70) and inhibit HSP-70 ?-globin binding, but which allow GATA-1 protein-HSP-1 binding in a manner that prevents GATA-1 proteolysis.
    Type: Grant
    Filed: November 19, 2014
    Date of Patent: June 28, 2016
    Assignees: Institut National de la Sante et de la Recherche Medicale (INSERM), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), Universite Paris Descartes—Paris V, Assistance Publique—Hopitaux de Paris, Fondation Imagine
    Inventors: Olivier Hermine, Genevieve Courtois, Jean-Benoit Arlet, Jean-Antoine Ribeil
  • METHODS AND COMPOSITIONS FOR THE TREATMENT OF BETA-THALASSEMIA
    Publication number: 20150141341
    Abstract: Methods and compositions for the treatment of ?-thalassemia are provided. Methods and compositions restore or increase erythrocyte maturation in individuals afflicted with ?-TM by preventing proteolysis of GATA-1 protein. Screening methods for identifying agents which bind heat shock protein 70 (HSP-70) and inhibit HSP-70 ?-globin binding, but which allow GATA-1 protein-HSP-1 binding in a manner that prevents GATA-1 proteolysis.
    Type: Application
    Filed: November 19, 2014
    Publication date: May 21, 2015
    Inventors: Olivier HERMINE, Genevieve COURTOIS, Jean-Benoit ARLET, Jean-Antoine RIBEIL