Patents by Inventor Jean C. Miller

Jean C. Miller has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Vinblastine oxazolidinedione disulfides and related compounds
    Patent number: 4362664
    Abstract: Thioalkyl derivatives of vinblastine 3-spiro-5"-oxazolidine-2",4"-dione, mitotic inhibitors.
    Type: Grant
    Filed: December 29, 1980
    Date of Patent: December 7, 1982
    Assignee: Eli Lilly and Company
    Inventors: Koert Gerzon, Jean C. Miller
  • Use of VLB 3-(2-chloroethyl) carboxamide in treating neoplasms
    Patent number: 4357334
    Abstract: VLB 3-(2-chloroethyl)carboxamide, the corresponding 4-desacetyl derivative and salts thereof, useful in treatment of neoplasms in pharmaceutical dosage forms.
    Type: Grant
    Filed: March 20, 1980
    Date of Patent: November 2, 1982
    Assignee: Eli Lilly and Company
    Inventors: Jean C. Miller, Gerald E. Gutowski
  • Antineoplastic 4'-formylamino and 4'-acetylamino VLB, and derivatives thereof
    Patent number: 4322351
    Abstract: 4'-Substituted VLB and vincristine, 4-desacetyl VLB, 4-desacetylvincristine and amides and hydrazides thereof, prepared by action of HCN or acetonitrile under strongly acidic conditions.
    Type: Grant
    Filed: August 25, 1980
    Date of Patent: March 30, 1982
    Assignee: Eli Lilly and Company
    Inventors: Jean C. Miller, Koert Gerzon
  • 20'-Hydroxyvinblastine and related compounds
    Patent number: 4320058
    Abstract: 20'-Hydroxy derivatives of VLB, leurosidine and vincristine, antimitotic agents.
    Type: Grant
    Filed: December 29, 1980
    Date of Patent: March 16, 1982
    Assignee: Eli Lilly and Company
    Inventors: Jean C. Miller, Gerald L. Thompson
  • Amides of leurosine, leuroformine, desacetylleurosine and desacetylleuroformine
    Patent number: 4191688
    Abstract: C-3 Carboxamides of leurosine, leuroformine, 4-desacetylleurosine and 4-desacetylleuroformine, useful as antitumor agents.
    Type: Grant
    Filed: June 12, 1978
    Date of Patent: March 4, 1980
    Assignee: Eli Lilly and Company
    Inventors: Robert A. Conrad, George J. Cullinan, Jean C. Miller, Koert Gerzon
  • Vinca alkaloid intermediates
    Patent number: 4160767
    Abstract: 3-Spiro-5"-oxazolidine-2",4"-dione derivatives of Vinca alkaloids, useful as anti-tumor agents and as intermediates.
    Type: Grant
    Filed: August 21, 1978
    Date of Patent: July 10, 1979
    Assignee: Eli Lilly and Company
    Inventors: Jean C. Miller, Gerald E. Gutowski
  • Preparation of oxazolidinedione derivatives of Vinca alkaloids
    Patent number: 4159269
    Abstract: 3-Spiro-5"-oxazolidine-2",4"-dione derivatives of Vinca alkaloids, useful as anti-tumor agents, synthesized from a C-3 carboxamide and a dialkyl carbonate.
    Type: Grant
    Filed: March 3, 1978
    Date of Patent: June 26, 1979
    Assignee: Eli Lilly and Company
    Inventor: Jean C. Miller
  • Oxazolidinedione derivatives of Vinca alkaloids
    Patent number: 4096148
    Abstract: 3-Spiro-5"-oxazolidine-2",4"-dione derivatives of Vinca alkaloids, useful as anti-tumor agents and as intermediates.
    Type: Grant
    Filed: December 6, 1976
    Date of Patent: June 20, 1978
    Assignee: Eli Lilly and Company
    Inventors: Jean C. Miller, Gerald E. Gutowski
  • 5' Acetoxy vinblastine 4' bis-sulfite
    Patent number: 4087429
    Abstract: Vincaleukoblastine (VLB, vinblastine) is reacted with thionyl chloride to form a bis-sulfite ester which is converted to various 5'-oxygenated derivatives.
    Type: Grant
    Filed: October 20, 1976
    Date of Patent: May 2, 1978
    Assignee: Eli Lilly and Company
    Inventors: Allen S. Katner, Gerald E. Gutowski, Jean C. Miller
  • Preparation of leurosidine and novel leurosidine 4'-ethers and esters
    Patent number: 4075214
    Abstract: Vincaleukoblastine (VLB, vinblastine) is converted to leurosidine, its 4' epimer, by reaction with thionyl chloride to form a bis-sulfite ester followed by treatment of the bis-sulfite ester with silver perchlorate. The bis-sulfite ester is covertible to novel 4' ethers by treatment with a lower alkanol or 4' esters of leurosidine perchlorate with acetic anhydride.
    Type: Grant
    Filed: May 17, 1976
    Date of Patent: February 21, 1978
    Assignee: Eli Lilly and Company
    Inventors: Allen S. Katner, Gerald E. Gutowski, Jean C. Miller
  • Dimeric anhydro-vinca derivatives
    Patent number: 4029663
    Abstract: Dimeric Vinca alkaloids are converted to three separable anhydro derivatives, useful as mitotic inhibitors or as intermediates for the preparation of other oncogenetically active alkaloids.
    Type: Grant
    Filed: July 10, 1975
    Date of Patent: June 14, 1977
    Assignee: Eli Lilly and Company
    Inventors: Gerald E. Gutowski, Jean C. Miller
  • Oxazolidinedione derivatives of Vinca alkaloids
    Patent number: RE30560
    Abstract: 3-Spiro-5"-oxazolidine-2",4"-dione derivatives of Vinca alkaloids, useful as anti-tumor agents and as intermediates.
    Type: Grant
    Filed: November 2, 1979
    Date of Patent: March 31, 1981
    Assignee: Eli Lilly and Company
    Inventors: Jean C. Miller, Gerald E. Gutowski
  • Vinca alkaloid intermediates
    Patent number: RE30561
    Abstract: 3-Spiro-5"-oxazolidine-2",4"-dione derivatives of Vinca alkaloids, useful as anti-tumor agents and as intermediates.
    Type: Grant
    Filed: November 2, 1979
    Date of Patent: March 31, 1981
    Assignee: Eli Lilly and Company
    Inventors: Jean C. Miller, Gerald E. Gutowski