Patents by Inventor Jean-Charles Grivel

Jean-Charles Grivel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Use of herpesviruses, herpesvirus proteins and nucleic acids encoding the proteins to inhibit CCR5-tropic HIV-1 infection and replication
    Patent number: 7968298
    Abstract: It has been discovered that herpesviruses can trigger an increase in the production of HIV-suppressive chemokines, and that these chemokines block the CCR5 receptor, which is used as a co-receptor with CD4 in the CCR5-tropic forms of HIV-1 that predominate in early stage HIV-1 infection. Use of live, attenuated or killed herpesviruses, or of herpesvirus proteins which trigger an increase in production of HIV-suppressive chemokines, or of nucleic acids encoding those proteins, can likewise be used to prevent establishment of HIV-1 infection or to inhibit HIV-1 replication. The invention provides uses, methods and compositions related to these discoveries.
    Type: Grant
    Filed: March 28, 2002
    Date of Patent: June 28, 2011
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Leonid B. Margolis, Jean-Charles Grivel, Paolo Lusso
  • Use of herpesviruses, herpesvirus proteins and nucleic acids encoding the proteins to inhibit ccr5-tropic hiv-1 infection and replication
    Publication number: 20050123510
    Abstract: It has been discovered that herpesviruses can trigger an increase in the production of HIV-suppressive chemokines, and that these chemokines block the CCR5 receptor, which is used as a co-receptor with CD4 in the CCR5-tropic forms of HIV-1 that predominate in early stage HIV-1 infection. Use of live, attenuated or killed herpesviruses, or of herpesvirus proteins which trigger an increase in production of HIV-suppressive chemokines, or of nucleic acids encoding those proteins, can likewise be used to prevent establishment of HIV-1 infection or to inhibit HIV-1 replication. The invention provides uses, methods and compositions related to these discoveries.
    Type: Application
    Filed: March 28, 2002
    Publication date: June 9, 2005
    Applicant: The Government of the United States, as represent- ed by the Secretary of Health and Human Services,
    Inventors: Leonid Margolis, Jean-Charles Grivel, Paolo Lusso