Patents by Inventor Jean-Christophe P. Harmange

Jean-Christophe P. Harmange has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • BIOMARKER-BASED TREATMENT OF FOCAL SEGMENTAL GLOMERULOSCLEROSIS AND DIABETIC KIDNEY DISEASE
    Publication number: 20240091303
    Abstract: Disclosed are compounds having structural formulas (I)-(XI), and related pharmaceutical compositions. Also disclosed are methods of selecting and treating human subjects suffering from a kidney disease, using the compounds of formulas (I)-(XI), and methods of determining the efficacy of TRPC5 inhibitor therapies using the same.
    Type: Application
    Filed: October 5, 2020
    Publication date: March 21, 2024
    Inventors: John Francis Reilly, Yossi Dagon, Hari Raghu, Marie-Francoise Yveline Coeffet-Le Gal, Matthew H. Daniels, Maolin Yu, Mark W. Ledeboer, Jean-Christophe P. Harmange, Peter H. Mundel
  • IMIDAZODIAZEPINEDIONES AND METHODS OF USE THEREOF
    Publication number: 20230365575
    Abstract: Disclosed are compounds according to Formula (I) or (II), and pharmaceutical compositions comprising them. Also disclosed are therapeutic methods, e.g., of treating kidney diseases, using the compounds of Formula (I) or (II).
    Type: Application
    Filed: February 1, 2023
    Publication date: November 16, 2023
    Inventors: Matthew H. Daniels, Maolin Yu, Jean-Christophe P. Harmange, Thomas T. Tibbitts, Mark W. Ledeboer, Neil A. Castle, Goran Malojcic
  • PYRIDAZINONES AND METHODS OF USE THEREOF
    Publication number: 20230203028
    Abstract: Disclosed are compounds according to Formula (A), and related tautomers and pharmaceutical compositions. Also disclosed are therapeutic methods, e.g., of treating kidney diseases, using the compounds of Formula (A).
    Type: Application
    Filed: September 18, 2018
    Publication date: June 29, 2023
    Inventors: Maolin Yu, Matthew H. Daniels, Jean-Christophe P. Harmange, Thomas T. Tibbitts, Mark W. Ledeboer, Goran Malojcic, Liron Walsh, Peter H. Mundel
  • 1,2,4-TRIAZOLINONE CB1 INHIBITORS
    Publication number: 20230192657
    Abstract: Disclosed are compounds according to Formula (I), and related pharmaceutical compositions. Also disclosed are therapeutic methods, e.g., of treating diseases such as diabetic kidney disease, diabetic nephropathy, obesity-related kidney disease, focal segmental glomerular sclerosis, IgA nephropathy, nephrotic syndrome, kidney fibrosis, Prader Willi syndrome, metabolic syndrome, gastrointestinal diseases, non-alcoholic liver disease, alcoholic liver disease, or non-alcoholic fatty liver disease, using the compounds of Formula (I).
    Type: Application
    Filed: March 1, 2021
    Publication date: June 22, 2023
    Inventors: Maolin Yu, Mark W. Ledeboer, Jean-Christophe P. Harmange
  • Imidazodiazepinediones and methods of use thereof
    Patent number: 11623930
    Abstract: Disclosed are compounds according to Formula (I) or (II), and pharmaceutical compositions comprising them. Also disclosed are therapeutic methods, e.g., of treating kidney diseases, using the compounds of Formula (I) or (II).
    Type: Grant
    Filed: March 5, 2019
    Date of Patent: April 11, 2023
    Assignee: Goldfinch Bio, Inc.
    Inventors: Matthew H. Daniels, Maolin Yu, Jean-Christophe P. Harmange, Thomas T. Tibbitts, Mark W. Ledeboer, Neil A. Castle, Goran Malojcic
  • SUBSTITUTED 1,6-NAPHTHYRIDINE INHIBITORS OF CDK5
    Publication number: 20220389009
    Abstract: Disclosed are compounds having structural formula I, and related salts and pharmaceutical compositions. Also disclosed are therapeutic methods, e.g., of treating diseases and conditions such as kidney disease, kidney failure, kidney stones, or polycystic kidney disease, using the compounds of formula (I), and related salts and pharmaceutical compositions.
    Type: Application
    Filed: October 1, 2020
    Publication date: December 8, 2022
    Inventors: Goran Malojcic, Matthew H. Daniels, Brett D. Williams, Maolin Yu, Mark W. Ledeboer, Jean-Christophe P. Harmange, Jenna L. Wang
  • XANTHINE CB1 INHIBITORS
    Publication number: 20220380370
    Abstract: Disclosed are compounds having structural formula I, and related pharmaceutical compositions. Also disclosed are therapeutic methods, e.g., of treating diseases such as diabetic kidney disease, diabetic nephropathy, obesity-related kidney disease, focal segmental glomerular sclerosis, IgA nephropathy, nephrotic syndrome, kidney fibrosis, Prader Willi syndrome, metabolic syndrome, gastrointestinal diseases, non-alcoholic liver disease, alcoholic liver disease, or non-alcoholic fatty liver disease, using the compounds of Formula (I).
    Type: Application
    Filed: September 25, 2020
    Publication date: December 1, 2022
    Inventors: Maolin Yu, Brett D. Williams, Mark W. Ledeboer, Jean-Christophe P. Harmange, Sydney E. Carra
  • PYRIDAZINONES AND METHODS OF USE THEREOF
    Publication number: 20220152031
    Abstract: Disclosed are therapeutic methods, e.g., of treating kidney diseases, using compounds of Formula (A) in combination with a second therapeutic agent.
    Type: Application
    Filed: March 18, 2020
    Publication date: May 19, 2022
    Inventors: John Francis Reilly, Liron Walsh, Peter H. Mundel, Amy Kieu Duyen Westerling-Bui, Matthew H. Daniels, Maolin Yu, Mark W. Ledeboer, Jean-Christophe P. Harmange, Marie-Francoise Yveline Coeffet-Le Gal, Michael Broxson
  • PYRIDAZINONES AND METHODS OF USE THEREOF
    Publication number: 20220024917
    Abstract: Disclosed are compounds according to Formula (I), and related pharmaceutical compositions. Also disclosed are therapeutic methods, e.g., of treating kidney diseases, using the compounds of Formula (I).
    Type: Application
    Filed: June 28, 2021
    Publication date: January 27, 2022
    Inventors: Mark W. Ledeboer, Matthew H. Daniels, Maolin Yu, Jean-Christophe P. Harmange
  • Pyridazinones and methods of use thereof
    Patent number: 11046690
    Abstract: Disclosed are compounds according to Formula (I), and related pharmaceutical compositions. Also disclosed are therapeutic methods, e.g., of treating kidney diseases, using the compounds of Formula (I).
    Type: Grant
    Filed: May 18, 2020
    Date of Patent: June 29, 2021
    Assignee: Goldfinch Bio, Inc.
    Inventors: Mark W. Ledeboer, Matthew H. Daniels, Maolin Yu, Jean-Christophe P. Harmange
  • AZAINDOLES AND METHODS OF USE THEREOF
    Publication number: 20210115036
    Abstract: Disclosed are compounds according to Formula (I) or (II), and pharmaceutical compositions comprising them. Also disclosed are therapeutic methods, e.g., of treating kidney diseases, using the compounds of Formula (I) or (II).
    Type: Application
    Filed: August 3, 2018
    Publication date: April 22, 2021
    Applicant: Goldfinch Bio, Inc.
    Inventors: Mark W. Ledeboer, Jean-Christophe P. Harmange, Thomas T. Tibbitts
  • IMIDAZODIAZEPINEDIONES AND METHODS OF USE THEREOF
    Publication number: 20210087200
    Abstract: Disclosed are compounds according to Formula (I) or (II), and pharmaceutical compositions comprising them. Also disclosed are therapeutic methods, e.g., of treating kidney diseases, using the compounds of Formula (I) or (II).
    Type: Application
    Filed: March 5, 2019
    Publication date: March 25, 2021
    Inventors: Matthew H. Daniels, Maolin Yu, Jean-Christophe P. Harmange, Thomas T. Tibbitts, Mark W. Ledeboer, Neil A. Castle, Goran Malojcic
  • BENZIMIDAZOLES AND AZA-BENZIMIDAZOLES, AND METHODS OF USE THEREOF
    Publication number: 20200377505
    Abstract: Disclosed are compounds according to Formula (I) or (II), and pharmaceutical compositions comprising them. Also disclosed are therapeutic methods, e.g., of treating kidney diseases, using the compounds of Formula (I) or (II).
    Type: Application
    Filed: August 3, 2018
    Publication date: December 3, 2020
    Inventors: Mark W. Ledeboer, Jean-Christophe P. Harmange, Maolin Yu, Thomas T. Tibbitts, Matthew H. Daniels
  • PYRIDAZINONES AND METHODS OF USE THEREOF
    Publication number: 20200283437
    Abstract: Disclosed are compounds according to Formula (I), and related pharmaceutical compositions. Also disclosed are therapeutic methods, e.g., of treating kidney diseases, using the compounds of Formula (I).
    Type: Application
    Filed: May 18, 2020
    Publication date: September 10, 2020
    Inventors: Mark W. Ledeboer, Matthew H. Daniels, Maolin Yu, Jean-Christophe P. Harmange
  • Pyridazinones and methods of use thereof
    Patent number: 10654850
    Abstract: Disclosed are compounds according to Formula (I), and related pharmaceutical compositions. Also disclosed are therapeutic methods, e.g., of treating kidney diseases, using the compounds of Formula (I).
    Type: Grant
    Filed: September 18, 2019
    Date of Patent: May 19, 2020
    Assignee: Goldfinch Bio, Inc.
    Inventors: Mark W. Ledeboer, Matthew H. Daniels, Maolin Yu, Jean-Christophe P. Harmange
  • PYRIDAZINONES AND METHODS OF USE THEREOF
    Publication number: 20200102301
    Abstract: Disclosed are compounds according to Formula (I), and related pharmaceutical compositions. Also disclosed are therapeutic methods, e.g., of treating kidney diseases, using the compounds of Formula (I).
    Type: Application
    Filed: September 18, 2019
    Publication date: April 2, 2020
    Inventors: Mark W. Ledeboer, Matthew H. Daniels, Maolin Yu, Jean-Christophe P. Harmange