Patents by Inventor Jean-Claude Yadan

Jean-Claude Yadan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Organoselenium compounds with pro-oxidant activity and pharmaceutical use thereof
    Patent number: 6057310
    Abstract: Compounds represented by the following formula I: ##STR1## in which: R.sup.1 to R.sup.5 can have various meanings of which alkyl, substituted or non-substituted aryl, and m is equal to 0 or 1, X is selected from (CR.sup.6 R.sup.7).sub.n in which n=0 or 1, and CO are disclosed. These compounds are useful as anti-tumor drugs, especially with pro-oxidizing activity.
    Type: Grant
    Filed: July 22, 1998
    Date of Patent: May 2, 2000
    Assignee: Oxis Isle of Man, Limited
    Inventors: Jinzhu Xu, Georges Appere, Jean Chaudiere, Jean-Claude Yadan
  • Aromatic diselenides and selenosulfides, their preparation and their uses, more particularly their therapeutical use
    Patent number: 6040328
    Abstract: The objects of the present invention are:novel organoselenium compounds: aromatic diselenides and selenosulphides;the use of said novel compounds as antioxidant agents;pharmaceutical compositions containing them;a method of preparation of said novel compounds.
    Type: Grant
    Filed: August 31, 1999
    Date of Patent: March 21, 2000
    Assignee: Oxis International S.A.
    Inventors: Catherine Tailhan-Lomont, Irene Erdelmeier, Marc Moutet, Jean Chaudiere, Jean-Claude Yadan
  • Use of novel organoselenium compounds as pro-oxidizing agents their methods of preparation and pharmaceutical compositions and application thereof
    Patent number: 6001825
    Abstract: Compounds represented by the following formula I: ##STR1## in which: R.sup.1 to R.sup.5 can have various meanings of which alkyl, substituted or non-substituted aryl, and m is equal to 0 or 1, X is selected from (CR.sup.6 R.sup.7).sub.n in which n=0 or 1, and CO are disclosed. These compounds are useful as anti-tumor drugs, especially with pro-oxidizing activity.
    Type: Grant
    Filed: December 20, 1996
    Date of Patent: December 14, 1999
    Assignee: Oxis Isle of Man, Limited
    Inventors: Jinzhu Xu, Georges Appere, Jean Chaudiere, Jean-Claude Yadan
  • Aromatic diselenides and selenosulfides, their preparation and their uses, more particularly their therapeutical use
    Patent number: 5973009
    Abstract: The objects of the present invention are:novel organoselenium compounds: aromatic diselenides and selenosulphides;the use of said novel compounds as antioxidant agents;pharmaceutical compositions containing them;a method of preparation of said novel compounds.
    Type: Grant
    Filed: December 23, 1997
    Date of Patent: October 26, 1999
    Assignee: Oxis International S.A.
    Inventors: Catherine Tailhan-Lomont, Irene Erdelmeier, Marc Moutet, Jean Chaudiere, Jean-Claude Yadan
  • Compounds having a benzisoselen-azoline and -azine structure, method for preparing same and therapeutic uses thereof
    Patent number: 5968920
    Abstract: The invention concerns novel benzisoselen-azoline and -azine derivatives. These novel derivatives have the following general formula (II): ##STR1## where: R.sup.1 to R.sup.8 and R.sup.10 have various meanings, in particular H, alkyl, etc . . . ; ##STR2## Y.sup.- represents the anion of a pharmaceutically acceptable anion; n=0, 1; m=0, 1, 2; p=1, 2, 3; q=2, 3, 4; r=0, 1; and their pharmaceutically acceptable salts of acids or bases; there being no more than one substituent R.sup.9 in each molecule with general formula II. These novel derivatives can be used in medication.
    Type: Grant
    Filed: January 30, 1996
    Date of Patent: October 19, 1999
    Assignee: Oxis Isle of Man, Limited
    Inventors: Irene Erdelmeier, Jean Chaudiere, Marc Moutet, Jean-Claude Yadan
  • Method of colorimetric analysis of malonic dialdehyde and 4-hydroxy-2-enaldehydes as indexes of lipid peroxidation, kits for carrying out said method, substituted indoles for use in said method and their preparation
    Patent number: 5726063
    Abstract: A colorimetric assay of enaldehydes or of malonic dialdehyde as lipid peroxidation indices in an aqueous medium includinga) addition to the medium of a reagent of a compound of general formula I and their optional addition salts with organic or inorganic bases or with organic or inorganic acids. ##STR1## in which formula: A and C, which may be identical or different, each represent H, ##STR2## wherein A and C cannot simultaneously represent H, with:R.sup.1 =H; alkyl; aralkyl; aryl substituted on the aryl ring; alkyl sulfonate Y.sup.+ ; alkyl phosphonate, Y.sup.+ ; or alkyl carboxylate, Y.sup.+ ;R.sup.2 =H; --OR.sup.4 ; F; Cl; Br; I; --NO.sub.2 ; SO.sub.3.sup.31 Y.sup.+ ; --CN; --COOR.sup.4 ; or --CONR.sup.5 R.sup.6 ;R.sup.3 =H; --OR.sup.4 ; --NR.sup.5 R.sup.6 ; --SR.sup.4 ; F; Cl; Br; I; --NO.sub.2 ; --SO.sub.3 --Y.sup.+ ; --CN; --COR.sup.5 ; --COOR.sup.4 ; or --CONR.sup.5 R.sup.6 ;R.sup.4 =H; alkyl; aralkyl; or aryl substituted on the aryl ring;R.sup.
    Type: Grant
    Filed: August 23, 1996
    Date of Patent: March 10, 1998
    Assignee: Oxis Isle of Man, Limited
    Inventors: Dominique Gerard-Monnier, Irene Erdelmeier, Jean Chaudiere, Jean-Claude Yadan